Results 41 to 50 of about 274,408 (179)

Targeting PRKCN, an Essential Driver Orchestrating mTOR‐IRF4 Axis Independently of Kinase Activity, in Multiple Myeloma

open access: yesAdvanced Science, EarlyView.
Constitutive PRKCN expression is driven by super‐enhancers and modulated by NF‐κB signaling in multiple myeloma (MM). PRKCN activates mTORC1/2‐IRF4 signaling axis and favors tumor cell growth independently of its kinase activity. IRF4 reciprocally promotes PRKCN transcription, creating a feed‐forward loop.
Koukou Tang   +12 more
wiley   +1 more source

Unravelling ethical dilemmas: how consultants’ decisions impact road construction project performance in Dar es Salaam and Tabora, Tanzania

open access: yesEastern African Journal of Humanities and Social Sciences
This study examines how consultants' decisions, shaped by ethical dilemmas, influence the performance of road construction projects in Tanzania. Grounded in the Virtue Theory of Ethics, the research explores the role of behavioural, socio-economic ...
Herry A. Mwankusye   +2 more
doaj   +1 more source

Information Technology, Moral Dilemmas, and Decision-Making

open access: yesIranian Journal of Information Processing & Management, 2022
The ethical significance of information technology due to its increasing intertwining with social life has led associations and organizations such as ACM and I-EEE to develop ethical principles and codes for the IT profession and to update them from time
Rahman Sharifzadeh,
doaj  

Reflections of Practicing School Principals on Ethical Leadership and Decision-Making: Confronting Social Injustice [PDF]

open access: yes, 2015
The study objective was to identify leadership dilemmas of practicing school administrators and their own codes of ethics to inform understandings of ethical decision-making. Ethical decision-making underpins leadership practice, theory, and preparation.
Gardiner, Mary E., Tenuto, Penny L.
core   +1 more source

An Implanted Tooth That Can Feel

open access: yesAdvanced Science, EarlyView.
To endow the implanted tooth with masticatory perception, herein we demonstrate that a 3D‐printed piezoelectric‐core/robust‐sheath implanted tooth can rebuild the sensing feedback, serving as “mechanoreceptors” in converting the mechanical chewing force to electrical signals, and up to brain through surrounding alveolar nerve system.
Yaru Cao   +13 more
wiley   +1 more source

Ethical dilemmas of kazakhstani journalists

open access: yesХабаршы Журналистика сериясы, 2022
A journalist is supposed to provide society with true, objective, balanced, up-to-date information and act fairly and impartially, be truthful and transparent. Otherwise, journalists may cause harm by failing to act ethically.
A. A. Kurmanova
doaj   +1 more source

Dilemmas in doing insider research in professional education [PDF]

open access: yes, 2012
This article explores the dilemmas I encountered when researching social work education in England as an insider researcher who was simultaneously employed as an educator in the host institution.
Adler PA   +17 more
core   +2 more sources

Soft Robotics and Advanced Technologies for Minimally Invasive Bioprinting: The Future of Internal Organ Repair

open access: yesAdvanced Science, EarlyView.
This review examines the evolution of bioprinting toward minimally invasive in situ strategies for internal organ regeneration. It defines the technological roadmap from handheld systems to advanced minimally invasive bioprinting platforms, positioning soft robotics as a core enabler.
Duc Tu Vu   +9 more
wiley   +1 more source

Dilemmas in Antenatal Reporting of Ambiguous Genitalia on Ultrasound, under Preconception and Prenatal Diagnostic Techniques Act, 1994 [PDF]

open access: yesJournal of Clinical and Diagnostic Research
Dear Editor, Author has written this letter to express her concern regarding the recent developments in the implementation of the Preconception and Prenatal Diagnostic Techniques (PCPNDT) Act.
Karishma Santosh Krishnani
doaj   +1 more source

The four principles: Can they be measured and do they predict ethical decision making? [PDF]

open access: yes, 2012
Background The four principles of Beauchamp and Childress - autonomy, non-maleficence, beneficence and justice - have been extremely influential in the field of medical ethics, and are fundamental for understanding the current approach to ethical ...
Page, Katie
core   +4 more sources

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