Results 61 to 70 of about 676,352 (266)

Ethical issues in psychopharmacology [PDF]

open access: yesJournal of Medical Ethics, 2006
The marketing of selective serotonin reuptake inhibitors in the psychopharmacological industry presents a serious moral problem for the corporate model of medicine. In this paper I examine ethical issues relating to the efficacy and safety of these drugs.
openaire   +2 more sources

Digital Technology and Healthcare: The Role of Health Technology Assessment

open access: yesApplied Medical Informatics, 2021
Background and Aim: Digital health technologies (DHTs) are one of the most promising perspectives in healthcare. On the other hand, the investment in of DHTs has an impact on the (ethical, economic, organizational, environmental) sustainability of ...
Dario SACCHINI   +4 more
doaj  

Incidental Findings: The Importance of Pretest Counseling

open access: yesPediatric Neurology Briefs, 2016
Researchers at the University of Bourgogne in Dijon, France surveyed French geneticists who were members of the “Association Français des Généticiens” on incidental findings (IF) found on array-based comparative genomic hybridization (aCGH) technology ...
Kathryn M. Buchtel, Elizabeth A. Leeth
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Ethical issues in dementia

open access: yesDialogues in Clinical Neuroscience, 2000
The growing number of individuals affected by dementia will intensify the ethical issues that emerge in clinical practice and research, issues early in disease relate to genetic testing, use of medications in mildly affected persons, and diagnostic disclosure.
openaire   +3 more sources

Surrogacy: Ethical and Legal Issues

open access: yesIndian Journal of Community Medicine, 2012
Surrogacy refers to a contract in which a woman carries a pregnancy "for"another couple. Number of infertile couples from all over the World approach India where commercial surrogacy is legal.
Pikee Saxena   +2 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Ethical Issues Faced by Registered Nurses at Selected Public Clinics of Mopani District, Limpopo Province, South Africa

open access: yesProceedings
Background: Ethics is an integral part of the nursing profession, forming the foundation thereof [...]
Tsakani Agnes Nyambi   +2 more
doaj   +1 more source

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