Results 101 to 110 of about 2,906,189 (349)

Ethical and legal considerations in healthcare AI: innovation and policy for safe and fair use

open access: yesRoyal Society Open Science
Artificial intelligence (AI) is transforming healthcare by enhancing diagnostics, personalizing medicine and improving surgical precision. However, its integration into healthcare systems raises significant ethical and legal challenges.
Tuan D. Pham
semanticscholar   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

U.S. Supreme Court in the civil rights era: Deliberative Democracy and its educative institutional role, 1950s–1970s

open access: yesAnnales Etyka w Życiu Gospodarczym, 2018
This article examines the U.S. Supreme Court’s lesser-known educative role as an egalitarian institution within a broader deliberative democratic process.
Carlos Figueroa
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Kurumsal Sosyal Sorumluluğun Satın Alma Niyeti Üzerindeki Etkisi: İstanbul İlinde Bir Araştırma

open access: yesİstanbul Gelişim Üniversitesi Sosyal Bilimler Dergisi, 2017
Bu çalışmanın amacı, kurumsal sosyal sorumluluğun satın alma niyeti üzerindeki etkisinin belirlenmesidir. Bu amaçla tasarlanan araştırmada ekonomik, yasal, etik ve gönüllü sosyal sorumluluk ele alınmış, bu boyutlarla birlikte satın alma niyetini ölçen ...
İlknur Bilgen, Gülsüm Vezir Oğuz
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Can corporate social responsibility help us understand the credit crisis? [PDF]

open access: yes
The financial crisis which started in the United States in 2007 and which has spread throughout the world has many causes, one of which is the abundance of unethical behavior on the part of many of those who made the financial decisions, such as ...
Argandoña, Antonio
core  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

The Philosophical Bottleneck of the Sustainable Development Ideal: The Problem of Future Generations

open access: yesİçtimaiyat
This article argues that at the core of the sustainable development concept lies a philosophical problem: the idea of moral responsibility toward future generations.
Vehbi Metin Demir
doaj   +1 more source

Home - About - Disclaimer - Privacy