Results 91 to 100 of about 380,615 (266)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Responsibility: The First Virtue of Innovation? A discussion of some ethical and meta-ethical issues concerning the concept of ‘responsibility’ in technological innovation

Nordicum-Mediterraneum, 2014
In this paper I investigate the concept of responsibility in the context of technological innovation, with reference to two types of responsibility: ex post and ex ante responsibility. Exposing the shortcomings of ex post responsibility in the context of
Espen D. Stabell
doaj  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

ETHICAL AND PHILANTHROPIC RESPONSIBILITIES IN PRACTICE [PDF]

Annals of the University of Petrosani: Economics, 2010
Along the time, enterprises were created as economic entities meant to supply goods and services to the members of society. Profit is the main incentive for entrepreneurs. First, the enterprise was the basic economic unit form for our society. Therefore,
GEORGETA GRIGORE
doaj  

The Impact of Ethical Social Responsibility and Spiritual Community on Occurrence of Deviant Behaviors in the Workplace: mediating role of Affective Commitment (Case of: Ferdowsi University of Mashhad)

مشاوره شغلی و سازمانی, 2019
The main purpose of this study is to investigate the impact of ethical social responsibility and spiritual Community on occurrence of deviant behaviors in the workplace considering the role of affective commitment. The sample is consisted of 600 Employee
غلامرضا ملک زاده, وسن کامل عفلوک الحسناوی, مرضیه ادیب زاده   +2 more
doaj  

Assessment of corporate social responsibility practices in selected public libraries in South-West and North-Central, Nigeria

International Journal of Corporate Social Responsibility
This study explored corporate social responsibility practices in selected public libraries in south-west and north-central Nigeria. The study adopts multiple case-study design, and qualitative research approach.
Ismail Olatunji Adeyemi, Boluke Favour Abiona, Adetunji Idris Adebisi, Khudro Iyabo Ishola, Halleluyah David Ogunlowo   +4 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Reducing misdiagnosis in AI-driven medical diagnostics: a multidimensional framework for technical, ethical, and policy solutions

Frontiers in Medicine
PurposeThis study aims to systematically identify and address key barriers to misdiagnosis in AI-driven medical diagnostics. The main research question is how technical limitations, ethical concerns, and unclear accountability hinder safe and equitable ...
Yue Li, Yue Li, Xin Yi, Jia Fu, Yujing Yang, ChuJie Duan, Jun Wang, Jun Wang   +7 more
doaj   +1 more source

[Vulnerabilities, ethical responsibility and acceptance of otherness during the first Covid lockdown: A case study of a French Care Centre for Support and Prevention in Addictology]. [PDF]

Ethique Sante, 2022
Marcucci L, Nutini S.
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source