Results 71 to 80 of about 380,615 (266)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Automating Justice: An Ethical Responsibility of Computational Bioethics. [PDF]

Am J Bioeth, 2022
Rahimzadeh V, Lawson J, Baek J, Dove ES.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

آليات مقترحة لتنمية الوعي بالمسؤوليات القانونية والأخلاقية لدى معلمي المدارس الابتدائية مدخلًا لتحقيق البيئة المدرسية الآمنة بمحافظة المنيا [PDF]

مجلة البحث في التربية وعلم النفس
استهدف هذا البحث تقديم تصور لآليات مقترحة لتنمية الوعي بالمسؤوليات القانونية والأخلاقية لدى معلمي المدارس الابتدائية بمحافظة المنيا، باعتباره متطلبًا أساسيًا لتعزيز قدرة المدارس على توفير بيئة تعليمية آمنة (جسديًا، نفسيًا، رقميًا، وصحيًا).
مصطفى أحمد شحاتة
doaj   +1 more source

The Author's Ethical Responsibility and the Ethics of Reading [PDF]

CounterText, 2018
Inspired by Ranjan Ghosh and J. Hillis Miller's intervention in Reading Literature across Continents, this essay discusses the narrative ethics of two narratives: Olga Horak's first-person narrative from the Holocaust and W. G. Sebald's novel Austerlitz (2001).
openaire   +3 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Public reporting of clinical trial findings as an ethical responsibility to participants: a qualitative study. [PDF]

BMJ Open, 2023
Morrow RL, Mintzes B, Gray G, Law MR, Garrison S, Dormuth CR.   +5 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The Importance of Responsibility in Times of Crisis

Nordicum-Mediterraneum, 2014
In this paper I would like to show the importance of the concept of responsibility as the foundation of ethics in times of crisis in particular in the fields of politics and economics in the modern civilisation marked by globalization and technological ...
Jacob Dahl Rendtorff
doaj