Results 91 to 100 of about 1,519,760 (306)

Is the Veil of Ignorance Transparent ? [PDF]

Theories of justice in the spirit of Rawls and Harsanyi argue that fair-minded people should aspire to make choices for society as if in the original position, that is, behind a veil of ignorance that prevents them from knowing their own social positions.
Cécile Renouard, Gaël Giraud
core   +3 more sources

The Ethics of Corporate Governance [PDF]

, 2008
How should corporate directors determine what is the right decision? For at least the past 30 years the debate has raged as to whether shareholder value should take precedence over corporate social responsibility when crucial decisions arise.
Ansoff H. I., Berle A. A., Bogle J., Child J. W., Coase R. H., Crowther D., Deephouse D. L., Donaldson T., Donaldson T., Evan W. M., Frankena W. K., Freeman R. E., Freeman R. E., Freeman R.E., Friedman M., Guthrie J., Hasnas J., Hendry J., Jensen M. C., Kant I., Kaplan R. S., Lindblom C. K., Maslow A., Mill J. S., Muth M. M., Porter M. E., Rust R. T., Stiles P., Wearing R., Weinberg P., Williamson O. E., Williamson O. E.   +31 more
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Reflections of Practicing School Principals on Ethical Leadership and Decision-Making: Confronting Social Injustice [PDF]

, 2015
The study objective was to identify leadership dilemmas of practicing school administrators and their own codes of ethics to inform understandings of ethical decision-making. Ethical decision-making underpins leadership practice, theory, and preparation.
Gardiner, Mary E., Tenuto, Penny L.
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Ethical Theories

Ethical theories provide frameworks for systematically reflecting on moral issues. However, their use in teaching engineering students is not without criticism. The abstractness, complexity, and nuances involved may overwhelm students, whereas overly simplistic applications often lead to questionable results.
Kühler, Michael, Wint, Natalie, Hillerbrand, Rafaela, Gimenez-Carbo, Ester   +3 more
openaire   +3 more sources

On the Development of an Ethical Demand Theory [PDF]

As an increasing number of consumers shift to demand products on the basis on production practices, animal welfare protocols, human rights initiatives, it is becoming important that we develop new tools for evaluating the decision-making frameworks in ...
Amanor-Boadu, Vincent
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Navigating the process of ethical approval: A methodological note

Grounded Theory Review: An International Journal, 2010
Classic grounded theory (CGT) methodology is a general methodology whereby the researcher aims to develop an emergent conceptual theory from empirical data collected by the researcher during the research study.
Eileen Carey
doaj