Results 91 to 100 of about 7,603,377 (331)

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

open access: yesMolecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho   +11 more
wiley   +1 more source

Comparison of the Medical Ethics Approaches according to Professional Experience and the Source of Medical Ethics Training: A Survey Study

open access: yesErciyes Medical Journal, 2020
Objective: This study aimed to compare the perspective on, the standard of knowledge and perceptions of medical ethics in the sixth-grade medical faculty students of a university hospital and the residents and academics working in the same hospital ...
Türev Demirtaş
doaj   +1 more source

MEDICAL ETHICS AND MEDICAL JOURNALS. [PDF]

open access: yesJAMA: The Journal of the American Medical Association, 1900
To most of us the average paper concerning our intraprofessional relations is somewhat tiresome. In many quarters the dignity of medical ethics has been most loudly preached by those lacking experience in its practice. It is little to be wondered at, therefore, that the subject is not a popular medical society topic.
openaire   +2 more sources

Addressing Medical Students' Negative Bias Toward Patients With Obesity Through Ethics Education.

open access: yesAMA journal of ethics, 2018
Context Negative bias toward patients with obesity is an ethical challenge in patient care. Several interventions to mitigate medical students' negative weight bias have been tried but none with an explicit focus on ethics.
G. Geller, Paul Watkins
semanticscholar   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

open access: yesMolecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski   +19 more
wiley   +1 more source

Testimony Before the Subcommittee of the Senate Judiciary Committee [PDF]

open access: yes, 1974
This testimony was originally published in the May 81, 1974 issue of Commonweal under the title Protecting the Unborn. Reprinted with permission from Commonweal, 232 Madison Avenue, New York , N. Y. 10016. Dr.
Ramsey, Paul
core   +1 more source

Nursing and midwifery students’ attitudes towards principles of medical ethics in Kermanshah, Iran

open access: yesBMC Medical Ethics, 2019
Professional ethics is one of the important topics, which includes various rights such as respecting the patient’s right to choose (autonomy), being useful (beneficence), being harmless (non- maleficence), and respecting the justice, integrity, and ...
H. Jafari   +3 more
semanticscholar   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

open access: yesMolecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau   +9 more
wiley   +1 more source

Clinical ethics: medical tourism in children. [PDF]

open access: yesArch Dis Child, 2021
Birchley G   +3 more
europepmc   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

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