Results 111 to 120 of about 53,494,435 (296)

Oncologists’ knowledge, practices and ethical opinions about therapeutic misconception: a French national survey

BMC Medical Ethics
Background Therapeutic misconception (TM) among research participants refers to the conflation of research goals (generating generalisable knowledge) with clinical care goals (making the best decisions for the participants).
Thibaud Haaser, S. Clair, S. Marty, D. Berdai, H. Hoarau, M. C. Saux, D. Dreyfuss, P. J. Maternowski   +7 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Un projet de recherche exempté d’évaluation éthique : quelques précisions

BioéthiqueOnline, 2013
This piece responds to the comments made by Caillé and Beauregard by offering clarifications regarding the exemption from ethics review of a research project.
Durand, Céline, Fortin, Marie-Chantal
doaj  

Through the eyes of Spanish-speaking patients, caregivers, and community leaders: a qualitative study on the in-patient hospital experience

International Journal for Equity in Health
Background Spanish-speakers with non-English language preference and complex medical needs suffer disparities in quality of care, safety, and health outcomes.
Nicholas V. Nguyen, Andres H. Guillen Lozoya, Maria A. Caruso, Maria Graciela D. Capetillo Porraz, Laura M. Pacheco-Spann, Megan A. Allyse, Amelia K. Barwise   +6 more
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Ethics in social research, its absences, urgencies, and possibilities: Critical proposals from Latin America

Salud Colectiva
Ethics in qualitative social research has particular features that distinguish it from the model formulated in the Global North for the health sciences, which is characterized by a universalist, quantitative, clinical approach and a limited critical ...
Rubén Muñoz Martínez
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Relational ethics between researchers: An Indigenous qualitative perspective

Methods in Psychology
Qualitative research has long emphasized the ethics of researcher-participant relationships, however far less attention has been given to the ethical complexities of relationships between research collaborators.
Gloria Fraser
doaj   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Leashes and Lies: Navigating the Colonial Tensions of Institutional Ethics of Research Involving Indigenous Peoples in Canada

International Indigenous Policy Journal, 2015
Ethical standards of conduct in research undertaken at Canadian universities involving humans has been guided by the three federal research funding agencies through the Tri-Council Policy Statement: Ethical Conduct for Research Involving Humans (or TCPS ...
Martha L. Stiegman, Heather Castleden
doaj