Results 31 to 40 of about 5,749,433 (313)

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

CBERN - The First Six Years: Challenges and Achievements [PDF]

open access: yes, 2012
CBERN was created in 2006. Its mandate was to create a network able to address critically, persuasively and visibly the foundational role of ethics in business and economic development. The task facing the network was significant. The field was fractured
Canadian Business Ethics Research Network (CBERN)
core  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Teaching professional ethics in counsellor education in Aotearoa New Zealand [PDF]

open access: yes, 2011
One mark of a profession is that it articulates a shared vision of the responsibilities involved in professional relationships, generally expressed in a Code of Ethics.
Crocket, Kathie
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Patient concerns about AI-based voice analysis in healthcare

open access: yesBMC Digital Health
Background Although AI-based voice analysis technology has potential utility for disease screening, diagnosis, clinical documentation, and safety monitoring, few studies have examined concerns that patients may have about the use of voice data for ...
J. E. Pacyna   +4 more
doaj   +1 more source

Shared decision making and advance care planning: a systematic literature review and novel decision-making model

open access: yesBMC Medical Ethics, 2023
Background and Aims Shared decision making (SDM) and advance care planning (ACP) are important evidence and ethics based concepts that can be translated in communication tools to aid the treatment decision-making process.
Ana Rosca   +5 more
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Evaluation of decision-making capacity in patients with dementia: challenges and recommendations from a secondary analysis of qualitative interviews

open access: yesBMC Medical Ethics, 2020
Background Evaluation of decision-making capacity to consent to medical treatment has proved to be difficult in patients with dementia. Studies showed that physicians are often insufficiently trained in the evaluation of decision-making capacity. In this
Christopher Poppe   +3 more
doaj   +1 more source

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