Results 121 to 130 of about 4,465,471 (397)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

“Donnez-moi une place”: an introduction to the theological ethics of France Quéré [PDF]

open access: yes, 2015
David Sinclair first presented this reflection on the writing of the French ethicist France Quéré (1936–95) at the inaugural meeting of the Church of Scotland’s Church and Society Council in order to demonstrate the kind of thinking that would be ...
Sinclair, David
core  

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Managing conflict of interest in ethics committee

open access: yesPerspectives in Clinical Research, 2018
The article discusses conflict of interest (COI) situations and how to manage COI in ethics committee (EC).
Arun Bhatt
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Fundamental Analysis of Duplicate Publication of Research Papers

open access: yesمجله دانشکده پزشکی اصفهان, 2010
Background: Duplicate publication is publication of a paper which overlaps with another published paper in many important parts and is essentially considered unethical.
Peyman Adibi   +2 more
doaj  

Adherence to the AAP's Institutional Ethics Committee Policy Recommendations. [PDF]

open access: yesHosp Pediatr, 2023
Weaver MS   +3 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

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