Results 51 to 60 of about 502,531 (303)

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

The Role of Compassion in Medical Ethics and Its Reintegration in Modern Practice [PDF]

, 2019
Compassion has been an integral part of medical ethics since its origins, but as medicine progressed, compassion slowly disappeared from practice.
Borchers, Hannah E
core   +1 more source

Evolving perspectives on broad consent for genomics research and biobanking in Africa. Report of the Second H3Africa Ethics Consultation Meeting, 11 May 2015. [PDF]

, 2016
A report on the Second H3Africa Ethics Consultation Meeting, which was held in Livingstone, Zambia on 11 May 2015. The meeting demonstrated considerable evolution by African Research Ethics Committees on thinking about broad consent as a consent option ...
de Vries, J, Littler, K, Matimba, A, McCurdy, S, Ouwe Missi Oukem-Boyer, O, Seeley, J, Tindana, P   +6 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Ethical ethics committees?: a response [PDF]

Journal of Medical Ethics, 2000
sir Following Dr Barber's letter1 relating to the mechanism for approval of Local Research Ethics Committees (LRECs), I have also had concerns over the intense pressure for a fast turn around for local approval. Projects may have been six months or more in the Multicentre Research Ethics Committe (MREC) process and then arrive on my desk with ...
openaire   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Preventing ethics dumping: the challenges for Kenyan research ethics committees

Research Ethics Review, 2021
Ethics dumping is the practice of undertaking research in a low- or middle-income setting which would not be permitted, or would be severely restricted, in a high-income setting.
Kate Chatfield, Doris Schroeder, Anastasia Guantai, Kirana Bhatt, Elizabeth Bukusi, Joyce Adhiambo Odhiambo, Julie Cook, Joshua Kimani   +7 more
doaj   +1 more source

Ethical Implications of Predictive Risk Intelligence [PDF]

, 2019
open access articleThis paper presents a case study on the ethical issues that relate to the use of Smart Information Systems (SIS) in predictive risk intelligence.
Jiya, Tilimbe
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Patient and nurse preferences for nurse handover - using preferences to inform policy: a discrete choice experiment protocol [PDF]

, 2015
Introduction Nursing bedside handover in hospital has been identified as an opportunity to involve patients and promote patient-centred care. It is important to consider the preferences of both patients and nurses when implementing bedside handover to ...
Anderson, Anderson, Australian Commission on Safety and Quality in Healthcare, Australian Commission on Safety and Quality in Healthcare, Australian Commission on Safety and Quality in Healthcare, Bridges, Cahill, Chaboyer, Chaboyer, Chin, Coast, de Bekker-Grob, de Bekker-Grob, Drach-Zahavy, Evans, Greaves, Grol, Hensher, Jeffs, Jeffs, Jeffs, Johnson, Johnson, Kerr, Kerr, Kerr, Lancaster, Liu, Lu, McMurray, McMurray, O'Connell, Reed Johnson, Riesenberg, Rose, Rutherford, Ryan, Scovell, Staggers, Taylor, Thurstone, Timonen, Tobiano, Tobiano, Tobiano, Train, Whitty, Wilson   +47 more
core   +1 more source