Results 91 to 100 of about 239,329 (263)

MSDS of Ethidium Bromide

open access: yes, 2016
The Materials Safety Data Sheet (MSDS) for Ethidium Bromide, a substance commonly used for DNA intercalation fluorescence marking.
openaire   +1 more source

KU80 suppresses endonuclease G activity to preserve genomic integrity

open access: yesThe FEBS Journal, EarlyView.
Under normal conditions, EndoG remains restricted to mitochondria and the genome remains intact. When KU80 is absent, EndoG translocates into the nucleus, where it promotes DNA fragmentation and genomic instability. Thus, this work highlights the importance of KU80 in tightly controlling EndoG localization to preserve genome stability.
Jargalan Batsaikhan   +8 more
wiley   +1 more source

Mycobacterium avium Subsp. paratuberculosis and Human Endogenous Retrovirus in Italian Patients With Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS)

open access: yesImmunology, EarlyView.
Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn's disease (CD), is a recognised gastrointestinal disorder. Mycobacterium avium subspecies paratuberculosis (MAP) is implicated in IBD pathogenesis. Persistent exposure and active infections by MAP may contribute to the unsilencing of human endogenous retroviruses (HERV ...
Stefano Ruberto   +14 more
wiley   +1 more source

Application of the comet assay in erythrocytes of Oreochromis niloticus (Pisces): a methodological comparison

open access: yesGenetics and Molecular Biology, 2009
The present study applied the comet assay to erythrocytes of Oreochromis niloticus with the aim of improving protocols to detect DNA damage in these cells, by using two distinct pHs (pH = 12.1 and pH > 13) and evaluating whether there is a correspondence
Cintya A. Christofoletti   +2 more
doaj  

Fluorometric determination of ethidium bromide efflux kinetics in Escherichia coli

open access: yesJournal of Biological Engineering, 2009
Background Efflux pump activity has been associated with multidrug resistance phenotypes in bacteria, compromising the effectiveness of antimicrobial therapy.
Monteiro Gabriel A   +9 more
doaj   +1 more source

A deep learning–clinical nomogram hybrid for predicting sentinel lymph node metastasis in melanoma

open access: yesJournal of the European Academy of Dermatology and Venereology, EarlyView.
We developed MISSLE, a deep learning–clinical nomogram hybrid model, to predict sentinel lymph node metastasis in invasive cutaneous melanoma with a high area under the receiver operating characteristic curve of 0.950 on the test set. MISSLE identifies key histopathological features and integrates AI for improved clinical decision‐making.
Minh‐Khang Le   +8 more
wiley   +1 more source

A cryptic targeting signal creates a mitochondrial FEN1 isoform with tailed R-Loop binding properties.

open access: yesPLoS ONE, 2013
A growing number of DNA transacting proteins is found in the nucleus and in mitochondria, including the DNA repair and replication protein Flap endonuclease 1, FEN1. Here we show a truncated FEN1 isoform is generated by alternative translation initiation,
Lawrence Kazak   +6 more
doaj   +1 more source

A fractal pattern of hierarchical genetic population structure in mixed stocks across fish segregated by dams revealed by genomic resources for curimba Prochilodus lineatus

open access: yesJournal of Fish Biology, EarlyView.
Abstract Genomic resources, new microsatellite markers and a novel observation of a fractal pattern in the genetic population structure are presented for curimba, Prochilodus lineatus, a freshwater migratory model species of South America. Our main goals were to investigate the presence of mixed fish stocks and the effects of damming‐induced ...
Gabriel M. Yazbeck   +5 more
wiley   +1 more source

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