Results 111 to 120 of about 246,567 (336)

Application of the comet assay in erythrocytes of Oreochromis niloticus (Pisces): a methodological comparison

open access: yesGenetics and Molecular Biology, 2009
The present study applied the comet assay to erythrocytes of Oreochromis niloticus with the aim of improving protocols to detect DNA damage in these cells, by using two distinct pHs (pH = 12.1 and pH > 13) and evaluating whether there is a correspondence
Cintya A. Christofoletti   +2 more
doaj  

A cryptic targeting signal creates a mitochondrial FEN1 isoform with tailed R-Loop binding properties.

open access: yesPLoS ONE, 2013
A growing number of DNA transacting proteins is found in the nucleus and in mitochondria, including the DNA repair and replication protein Flap endonuclease 1, FEN1. Here we show a truncated FEN1 isoform is generated by alternative translation initiation,
Lawrence Kazak   +6 more
doaj   +1 more source

Monodentate Phosphine Modulation in Cyclometallated Platinum(II) Complexes for Antileishmanial, Antiviral, and Antitumor Applications

open access: yesChemMedChem, EarlyView.
Schematic representation depicting the influence of phosphine ligand identity on the biological and physicochemical characteristics of Pt(II) complexes: PTA promotes antileishmanial activity, PPh2(Php–COOH) strengthens antiviral activity, and TCEP enhances fluorescence.
Antonio A. de Oliveira‐Neto   +12 more
wiley   +1 more source

Staining of RNA and DNA on electrophoretic gels and in cytology with juice of Vaccinium myrtillus berries

open access: yesHeliyon, 2019
Background: My early results of cytological chromosome staining with berry juice of blueberry or bilberry (Vaccinium myrtillus) was re-evaluated with staining of electrophoretic agarose and polyacrylamide gels, fractionating DNA, RNA, and proteins ...
Hannu Ahokas
doaj   +1 more source

Lean ZSF1 rats in basic research on heart failure with preserved ejection fraction

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1474-1478, April 2025.
Abstract Aims ZSF1 obese rats harbouring two mutant leptin receptor alleles (Leprcp and Leprfa) develop metabolic syndrome and heart failure with preserved ejection fraction (HFpEF), making them a widely used animal model in cardiometabolic research.
Petra Büttner   +10 more
wiley   +1 more source

Molecular engineering of chiral colloidal liquid crystals using DNA origami

open access: yes, 2017
Establishing precise control over the shape and the interactions of the microscopic building blocks is essential for design of macroscopic soft materials with novel structural, optical and mechanical properties.
Dietz, Hendrik   +5 more
core   +1 more source

pH‐Responsive Sodium Alginate Micro‐Nano Hydrogels for Oral Insulin Delivery: Enhancing Therapeutic Efficacy and Reducing Hypoglycemic Risk

open access: yesFood Frontiers, EarlyView.
Schematic illustration of pH‐responsive SC@AP@INS for oral insulin delivery. (A) pH‐responsive mechanism of sodium alginate‐based hydrogels. (B) Preparation of drug‐loaded microsphere gel via the electrospray method. The controlled release of drug‐loaded micelles in the colon enhances insulin delivery efficiency while minimizing systemic exposure and ...
Minghui Kong   +3 more
wiley   +1 more source

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