Results 251 to 260 of about 246,567 (336)

Genetic Diversity of Neospora Caninum in Palestinian Cattle and Sheep: Insights From Nc‐5 Gene Detection and MS10 Microsatellite Analysis

Veterinary Medicine and Science, Volume 12, Issue 1, January 2026.
N. caninum DNA was detected in 24.2% of sampled cattle and sheep brains, with a higher prevalence in cattle (25.5%) than sheep (16.7%). Palestinian isolates formed one cluster, with the ACT allele predominating (76%). Phylogenetic analysis revealed low genetic diversity in N. caninum globally.
Heba Farajeen, Suheir Ereqat, Amer Al‐Jawabreh, Abedelmajeed Nasereddin   +3 more
wiley   +1 more source

Betulinic Acid Eradicates Implant‐Associated Infections by Disrupting the S. aureus Biofilm Matrix and Potentiating Host Immune Clearance

Microbial Biotechnology, Volume 19, Issue 1, January 2026.
Betulinic acid reduces infection by Staphylococcus aureus biofilms on implants by inhibiting their formation and adhesion, decreasing EPS and eDNA formation and enhancing immune clearance. Simultaneously, it reduces skin tissue inflammation, enhances type I collagen production, and promotes wound healing.
Dongbin Guo, Ye Tao, Luanbiao Sun, Xinyao Liu, Yuan Gao, Peitong Jiang, Han Gao, Bingmei Wang, Li Wang   +8 more
wiley   +1 more source

The combinatorial deletion of mycobacterial dd-carboxypeptidases is readily tolerated in Mycobacterium smegmatis. [PDF]

Access Microbiol
Ealand CS, Moodley D, Ismail ZS, Maphatsoe M, Campbell L, Jacobs O, Kana BD.   +6 more
europepmc   +1 more source

NRF2 signalling in cytoprotection and metabolism

British Journal of Pharmacology, Volume 183, Issue 1, Page 101-114, January 2026.
The KEAP1‐NRF2 system plays a central role in cytoprotection in defence mechanisms against oxidative stress. The KEAP1‐NRF2 system has been regarded as a sulfur‐utilizing cytoprotective mechanism, because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and NRF2 is a transcriptional factor regulating genes involved in sulfur ...
Shohei Murakami, Yusuke Kusano, Keito Okazaki, Takaaki Akaike, Hozumi Motohashi   +4 more
wiley   +1 more source

Isolation and subtyping of avian influenza A virus from wild birds in Khartoum, Sudan. [PDF]

Onderstepoort J Vet Res
Ali WH, Saeed IK, Mutwakil SM, Alamin MH, Balla AA, Ahmed MAE, Saeed AA, Asil RM, Algezoli OA, Abdellatif MM, Ali YH.   +10 more
europepmc   +1 more source

Comparative Investigation of Cytotoxic Effects of Structurally Diverse Small Molecules and In Silico Analysis of 1‐Acetyl‐4‐(4‐Hydroxyphenyl)piperazine

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT This study assessed the anticancer activity of boron‐containing and structurally diverse small molecules in 4T1 breast cancer and Caco‐2 colon adenocarcinoma cells. Initial screening showed that five boronic acids lacked significant cytotoxicity, underscoring the structural specificity required for boron‐mediated bioactivity.
Azmi Yerlikaya, Emrah Tümer, Mustafa Güzel   +2 more
wiley   +1 more source

Strain-dependent contribution of the AcrAB-TolC efflux pump to <i>Klebsiella pneumoniae</i> physiology. [PDF]

Microbiology (Reading)
Bhogal K, Clough B, Emmerson C, Organ A, Chen Y, Buckner MM, Alav I.   +6 more
europepmc   +1 more source

Betulinic Acid Suppresses UBE2T Expression via MAPK/ERK Inhibition to Block FANCI and FANCD2 Monoubiquitination in Glioblastoma

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT Platinum‐based chemotherapy remains a cornerstone of glioma treatment, yet resistance driven by the Fanconi anaemia (FA) DNA repair pathway limits efficacy. Here, we identified betulinic acid (BA) as a potent inhibitor of FA pathway activation.
Yifeng Bao, Maode Wang
wiley   +1 more source

The PI3K Inhibitor HCD Promotes Caspase Activation in Head and Neck Squamous Cells by Upregulating the Extrinsic and Intrinsic Apoptosis Pathways

Journal of Oral Pathology &Medicine, Volume 55, Issue 1, Page 61-72, January 2026.
ABSTRACT Background 16‐hydroxycleroda‐3,13‐dien‐15,16‐olide (HCD), a compound isolated from Polyalthia longifolia var. pendula, has been identified as a PI3K inhibitor. P. longifolia var. pendula is recognized for its diverse pharmacological properties, including antimicrobial, hypotensive, anti‐inflammatory, and cytotoxic activities.
Leong‐Perng Chan, Ya‐Ping Tseng, Hui‐Ching Wang, Chen‐Yu Chien, Che‐Wei Wu, Ling‐Feng Wang, Tung‐Wen Yen, Po‐Chun Wang, Chih‐Chuang Liaw, Chia‐Hua Liang   +9 more
wiley   +1 more source

ArcA modulates multidrug resistance and compound susceptibility in <i>Klebsiella pneumoniae</i> through ArcB-independent regulation of the SMR efflux pump kpnEF. [PDF]

Microbiol Spectr
Fu T, Fan Z, Chen Y, Li Z, Liu H, Du B, Cui X, Feng Y, Zhao H, Xue G, Cui J, Yan C, Gan L, Feng J, Xu Z, Yang Y, Yu Z, Ke Y, Yuan J.   +18 more
europepmc   +1 more source