Results 291 to 300 of about 246,567 (336)

Ethidium bromide enhancement of frameshift mutagenesis caused by photoactivatable ethidium analogs

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1979
Ethidium azide analogs (3-amino-8-azido-ethidium monoazide and ethidium diazide) have been developed as photosensitive probes in order to analyze directly the reversible in vivo interactions of ethidium bromide. Our preliminary observations [11], relating the mutagenic potential of the monoazide analog of ethidium, have been extended and refined, using
L W, Yielding, B R, Brown, D E, Graves, K L, Yielding   +3 more
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Metabolism of ethidium bromide in rats.

Drug Metabolism and Disposition, 1981
The biliary excretion products recovered after iv administration of ethidium bromide to rats were found to consist of: unchanged drug, 8-acetylethidium, and an 8-acetylated hydroxylated metabolite. Proofs of structure were obtained by field desorption mass spectroscopy and 1H NMR, which indicated that the latter metabolite is probably substituted at ...
C, Fraire, P, Lecointe, C, Paoletti
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Ethidium Bromide Interaction with Poly(G)

Biophysical Reviews and Letters, 2014
In current work we investigate the interaction between polyguanylic acid and Ethidium Bromide ( EtBr ) and the changes of thermodynamic parameters due to those interactions by spectrophotometric methods. From the binding isotherms, binding constants were calculated for three different temperatures and the changes of Gibbs free energy, entropy and ...
Poghos H. Vardevanyan, Marine A. Parsadanyan, Mikayel V. Minasyants   +2 more
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Resistance to ethidium bromide inAspergillus nidulans

Experientia, 1979
A mutant ofAspergillus nidulans resistant to ethidium bromide was isolated and the semi-dominant gene responsible for this resistance was allocated on linkage group II at 17.42±3.05 units of recombination from thewA3 gene. The gene also confers cross-resistance to acriflavin, malachite green and crystal violet.
M. E. Scarazzatti, R. Bonatelli, J. L. Azevedo   +2 more
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Binding of ethidium bromide to fractionated chromatin

Experimental Cell Research, 1976
Abstract The binding of ethidium bromide (EB) to different chromatin preparations was tested. Scatchard plots showed that the slowly sedimenting fraction of sheared chromatin is enriched in dye-binding sites. Limited nuclease digestion of rat liver nuclei, which has been shown to preserve the subunit structure of chromatin, reduces the number of ...
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Binding of ethidium bromide to avian erythrocyte chromatin

Biochemical and Biophysical Research Communications, 1972
Summary Ethidium bromide intercalation studies indicate that mature avian erythrocyte chromatin has 5.6 times fewer primary binding sites than deproteinized DNA. The number of both primary and secondary binding sites was increased upon removal of chromosomal proteins; among those, removal of avian erythrocyte specific histone V shows the highest ...
P F, Lurquin, V L, Seligy
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Studies on Ethidium Bromide

British Veterinary Journal, 1954
A.A. Karib, E.J.H. Ford, E.C. Wilmshurst
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Neurotoxic Effects of Ethidium Bromide, Rat

1988
Pathologic lesions are produced by a direct exposure of the central and peripheral nervous tissues to ethidium bromide which is a red dye. Therefore the lesion appears red or reddish-orange and softer than the surrounding tissue.
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Complex formation between ethidium bromide and nucleic acids

Journal of Molecular Biology, 1965
The interaction between ethidium bromide and nucleic acids shows a pronounced metachromatic effect which has been used to obtain quantitative data on the process of complex formation. Ethidium binds strongly to both DNA and RNA at sites which appear to be saturated when one drug molecule is bound for every 4 or 5 nucleotides.
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Ethidium bromide resistance and enhancement of mitochondrial recombination

Molecular and General Genetics MGG, 1974
In some yeast cytoplasmic mutants, ethidium bromide resistance is expressed at the mitochondrial level. In homosexual crosses it leads to an enhanced recombination between two linked mitochondrial genes controlling chloramphenicol and erythromycin resistance or sensitivity, but recombination is still reciprocal.
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