Results 151 to 160 of about 1,632,868 (357)

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

On the Theory of Ethnic Conflict [PDF]

open access: yes
We present a theory of ethnic conflict in which coalitions formed along ethnic lines compete for the economy%u2019s resources. The role of ethnicity is to enforce coalition membership: in ethnically homogeneous societies members of the losing coalition ...
Francesco Caselli   +1 more
core  

Ethnic Identity, Self-Esteem & Intra Group Conflicts Amongst Latinos [PDF]

open access: yes, 2018
Unlike Salvadorans, Mexican/Mexican Americans have long established communities revolved around their culture. They have advanced in social class, education and political representation.
Arevalo, Christian
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

THE ROLE AND PLACE OF TRADITIONAL SOCIAL INSTITUTES IN THE TIME OF SOCIAL MODERNIZATION IN RUSSIA IN THE EARLY 21st CENTURY

open access: yesRUDN Journal of Public Administration, 2015
The article is devoted to the problem of interaction and mutual influence between modernization processes in contemporary Russian society and traditional social institutions of some Nations of Russian Federation.
Dmitry V Yurkov
doaj  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Ethnic Enclaves and Immigrant Labour Market Outcomes: Quasi-Experimental Evidence. [PDF]

open access: yes
This study investigates empirically how residence in ethnic enclaves affects labour market outcomes of refugees. Self-selection into ethnic enclaves in terms of unobservable characteristics is taken into account by exploitation of a Danish spatial ...
Damm, Anna Piil
core   +3 more sources

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