Results 161 to 170 of about 503,750 (307)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Population Genetic Data for 23 STR Loci of the Garifuna Ethnic Group in Honduras. [PDF]

Genes (Basel)
Zuniga A, Molina Y, Amaya K, Moya Z, Soriano P, Pineda D, Pinto Y, Garcia O, Zablah I.   +8 more
europepmc   +1 more source

Intergenerational trauma and war-induced PTSD in Kosovo: insights from the Albanian ethnic group. [PDF]

Front Psychol, 2023
Hyseni Duraku Z, Jahiu G, Geci D.
europepmc   +1 more source

Ethnic Diversity and Ethnic Strife: An Interdisciplinary Perspective

The objective of this paper is to present an overview of ethnicity, ethnic strife and its consequences, as seen from the perspective of the disciplines of economics, political science, social anthropology and sociology.
Rajaram, Prem Kumar, Varshney, Ashutosh, Kanbur, Ravi   +2 more
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Sociocultural Factors Affecting Chronic Disease Management Among the Hispanic/Latino Ethnic Group in Texas: A Qualitative Study. [PDF]

Health Serv Insights
Ortega C, Cho YJ, Vidal G, Brannon GE, Vazquez CE, Kim Y.   +5 more
europepmc   +1 more source

Wild edible plants and their cultural significance among the Zhuang ethnic group in Fangchenggang, Guangxi, China. [PDF]

J Ethnobiol Ethnomed, 2023
Liu S, Huang X, Bin Z, Yu B, Lu Z, Hu R, Long C.   +6 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Study on sound insulation performance of walls in traditional timber dwellings of the Miao ethnic group in Qiandongnan. [PDF]

Sci Rep
Huang X, Zhao W, Huang Z, Wang Y, Du Y, Du L, Chen Y.   +6 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source