β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero+8 more
wiley +1 more source
Cultural practices, oral health service utilisation and oral health policy and guidelines development in Africa: insights from the yorùbá ethnic group. [PDF]
Foláyan MO+8 more
europepmc +1 more source
Investigating the multidimensional relative poverty in China: Evidence from Nanling Yao ethnic group area. [PDF]
Luo H, Shu Y, Cai Z.
europepmc +1 more source
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li+12 more
wiley +1 more source
Ethnobotany study on wild edible plants used by the Tujia ethnic group in Laifeng, southwest Hubei, China. [PDF]
Hou S, Huang P, Yao Z.
europepmc +1 more source
Race and ethnic group dependent space radiation cancer risk predictions. [PDF]
Cucinotta FA, Saganti PB.
europepmc +1 more source
Accuracy of variables describing ethnic minority groups is important [PDF]
Kwame McKenzie
openalex +1 more source
Incidence of haematological malignancies by ethnic group in England, 2001–7
Megan H Shirley+4 more
semanticscholar +1 more source
Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza+3 more
wiley +1 more source
Health literacy and associated factors in China: findings from the Wa ethnic group. [PDF]
Yang W+14 more
europepmc +1 more source