Results 201 to 210 of about 14,292,945 (405)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

De-Biasing the Bias: Methods for Improving Disparity Assessments with Noisy Group Measurements [PDF]

open access: yesarXiv
Health care decisions are increasingly informed by clinical decision support algorithms, but these algorithms may perpetuate or increase racial and ethnic disparities in access to and quality of health care. Further complicating the problem, clinical data often have missing or poor quality racial and ethnic information, which can lead to misleading ...
arxiv  

Race and Ethnic Group Differences in Comorbid Major Depressive Disorder, Generalized Anxiety Disorder, and Chronic Medical Conditions

open access: yesJournal of Racial and Ethnic Health Disparities, 2015
Daphne C. Watkins   +2 more
semanticscholar   +1 more source

Age and Ethnic Variations in Attitudes Towards Older Persons, Family and Filial Obligations [PDF]

open access: yes, 1993
Two major interpretations have been advanced to explain the frequent finding that ethnic elders have more extensive kin support networks than Anglo elders. Structural interpretations argue that the exigencies of poverty and ill health cause minorities to
Ortega, Suzanne T., Shafer, John
core   +1 more source

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