Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Linguistic repertoire and training in transnational spaces
Ra XimhaiQualitative study carried out with young indigenous migrants from San Bernardino Chalchihuapan, Puebla, who have plurilingual linguistic repertoires. The purpose of the research is to understand their educational path in relation to the acquisition of ...
Martha Josefina Franco García +1 more
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Forced assimilation and development : the Chinese-Indonesians under Soeharto's New Order (1965-1998) : a research project presented in partial fulfilment of the requirements for the degree of Master of International Development, Development Studies, Massey University, Manawatu, New Zealand [PDF]
, 2014 Chinese Indonesians are an ethnic minority who have settled in Indonesia since at least the 15th century who comprise 1.2% of the Indonesian population.
Sidjaya, Calvin Michel
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Mongolian Interethnic Marriage, Ethnic Relations, and National Integration in the PRC
GenealogyInterethnic marriage amongst China’s ethnic population has not received the attention it deserves. This is partly due to the hesitation and resistance of the more prominent ethnic groups—Tibetans and Uyghurs—to enter an interethnic marriage. Still, it is
William ronald Jankowiak
doaj +1 more source
Securitised Ethnic Identities and Communal Conflicts [PDF]
, 1997 Excerpt The paper is inspired by Ernesto Laclau\u27s (1996, p. 46) observation of the terrain into which history has thrown us. The terrain is characterised by: [...] the multiplication of new--and not so new--identities as a result of the collapse of ...
Väyrynen, Tarja
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
The Politics of Imagining and Forgetting in Chinese Ethnic Minorities' Museums
Outlines, 2010 Through an exploration of the representation of ethnic minorities in the museums of Kunming, Yunnan Province of China, this article discusses the active role that museums play in the processes of memory and identity engineering, whereby museum images and
Marzia Varutti
doaj
The Changing Faces of America’s Children and Youth [PDF]
, 2010 Recent U.S. Census Bureau projections indicate that by the middle of this century, non-Hispanic whites will cease to be a majority of the American population.
Johnson, Kenneth M., Lichter, Daniel T.
core +2 more sources