Results 141 to 150 of about 425,744 (300)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Immigrant Health--Selectivity and Acculturation [PDF]

open access: yes
This paper explores some salient issues concerning immigrant health. Ethnic health disparities are inherently linked to immigration since ethnic identities often are traced to the country of origin of one's immigrant ancestors.
Douglas S. Massey   +3 more
core  

Settler colonialism, multiculturalism and the politics of postcolonial identity [PDF]

open access: yes, 2015
The twentieth century saw the development of nationalism and the construction of postcolonial identities in many newly independent nations. Formerly colonised peoples have struggled to restore and adapt their customs and to construct postcolonial ...
Lovell, Melissa
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Representation of ethnic identities in Turkish advertisements

open access: yesFrench Journal for Media Research, 2016
Dans le monde d’aujourd’hui où tout est formé selon les besoins et les demandes des consommateurs, la détermination de ces derniers et la réalisation d’activités de marketing intégrées offre un avantage compétitif significatif aux marques. S’adresser aux
Ozturk R.Gulay
doaj  

Do Religious Factors Impact Armed Conflict? Empirical Evidence from Sub-Saharan Africa [PDF]

open access: yes
Theoretically, the “mobilization hypothesis” establishes a link between religion and conflict by arguing that religious structures such as overlapping ethnic and religious identities are prone to mobilization; once politicized, escalation to violent ...
Georg Strüver   +3 more
core  

Claiming spaces: Maori (indigenous persons) making the invalid valid [PDF]

open access: yes, 2008
Identity is a shifting paradigm because of the constant movement between identities throughout our lives, depending on the context within which we are identifying ourselves. Once we identify, we place ourselves within a certain construct.
Hickey, Huhana
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

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