Results 101 to 110 of about 1,752,841 (343)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Overcoming barriers to recruiting ethnic minorities to mental health research: a typology of recruitment strategies

BMC Psychiatry, 2015
BackgroundThe ethnic minority population in developed countries is increasing over time. These groups are at higher risk of mental illness and demonstrate lower participation in research.
W. Waheed, A. Hughes-Morley, Adrine Woodham, Gill Allen, P. Bower   +4 more
semanticscholar   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Significantly Increased Public Interest in Sleep Disorder during the COVID-19 Pandemic: An Analysis of Google Trends Data

Journal of Education, Health and Sport
Background: The COVID-19 pandemic has had a profound impact on sleep disorders. Previous studies have shown that people's sleep time is delayed. Methods: Analyze the public's interest to the keyword "sleep disorder" during the COVID-19 pandemic from ...
Qinyi Tan, Xiaolu Chen, Yidan Cui, Hao Sun, Luyan Teng   +4 more
doaj   +1 more source

Analysis on the semantic evolution of Chinese Gan dialect from the perspective of cognition

SHS Web of Conferences, 2016
The meaning of a word is the reflection of social life, and it is the result of the cognition of the object, phenomenon and relationship through the mental activity. The development and changes of lexical mean-ings essentially reflect the development and
Xiao Jiugen, Chen Xijuan, Xiong Lingjun
doaj   +1 more source

Ethnic conflict regulation and Lithuanian experience in the last decade

Politologija, 2000
There exists a rather generally accepted view that ethnic diversity of a polity is an additional source of internal instability and sometimes negatively affects the state's international standing.
Nortautas Statkus
doaj   +1 more source

Introduction : Divided against themselves? Ethnic minorities, nationalism, and fractured anti-fascist identities

, 2023
Europe contained 36 million people classified as ethnic minorities in the interwar period. The vast majority, 25 million, lived in East Central Europe. With ultranationalism, xenophobia and racism rampant among the majority populations, this was a hotbed
Braskén, Kasper, Ahlbäck, Anders,
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Social Determinants of Labor Market Status of Ethnic Minorities in Britain [PDF]

The labor market behavior of ethnic communities in advanced societies and the social determinants of labor market outcomes of minority groups are important empirical issues with significant policy consequences.
Mariapia Mendola, Martin Kahanec
core  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source