Results 31 to 40 of about 455,649 (303)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Uyghur Turkic Women and Cultural Change: Young Moslem Women Face the Future [PDF]

Athens Journal of Humanities & Arts, 2014
The culture of the Turkic people now extends from the Mediterranean to Western China. The goal of this investigation is to show the importance of anthropological and sociological theory in investigating the profound changes in the world of Central Asia ...
David Makofsky
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Internet use, cultural consumption, and subjective well-being: exploring the mediating role in rural China

BMC Psychology
Purpose This study investigates the impact of internet use on the subjective well-being of Chinese rural residents, with a focus on the mediating role of cultural consumption.
Penghui Wu, Ming Zhang, Qing Chang, Jinhuika Ying   +3 more
doaj   +1 more source

The Essence and Orientation of Educational Evaluation Reform in the New Era: What Kind of Educational Evaluation Do We Need in the New Era

Jiaoshi jiaoyu xuebao
The reform of educational evaluation in the new era means that educational evaluation has entered a new stage of development, which will demonstrate extraordinary value and strategic significance in politics, history, and reality. Understanding what kind
ZHU Dequan, CAO Dufan
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Ethnic minority immigrants and their children in Britain [PDF]

This paper investigates educational attainment and economic behaviour of ethnic minority immigrants and their children in Britain. Despite their strong educational achievements, ethnic minority immigrants and their descendants exhibit lower employment ...
Christian Dustmann, Nikolaos Theodoropoulos   +1 more
core   +3 more sources

Reviewing the Problems in Rural Teacher Policy Instrumentsand Optimization Strategies: Based on the Analysis Framework of McDonnel and Elmore

Jiaoshi jiaoyu xuebao
As a comprehensive education and livelihood project, the construction of the rural teacher workforce is an important aspect of promoting the strategy of rural revitalization and deepening educational reform.
CHEN Hui, LI Chencheng
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source