Results 71 to 80 of about 932,927 (253)

THERACOM : a systematic review of the evidence base for interventions to improve Therapeutic Communications between black and minority ethnic populations and staff in specialist mental health services [PDF]

, 2013
Background: Black and Minority Ethnic (BME) groups in receipt of specialist mental health care have reported higher rates of detention under the mental health act, less use of psychological therapies, and more dissatisfaction.
Johnson, Mark, Singh, S., McCabe, R, Kamaldeep Bhui, Johnson, M., Swaran Singh, Weich, S., Bhui, Kamaldeep S., McCabe, R., Bhui, Kamaldeep, McCabe, Rosemarie, Weich, S, McCabe, Rose, Szczepura, A, Scott Weich, Szczepura, A., Rosemarie McCabe, Szczepura, Ala; id_orcid, Szczepura, Ala, Singh, S, Johnson, Mark R. D., Johnson, M, Bhui, K, Bhui, K., Singh, Swaran P., Ala Szczepura, Mark Johnson, Weich, Scott   +27 more
core   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Policy interventions for minority ethnic young people and Decent Work [PDF]

, 2022
Minority ethnic young people in most countries are some of the most likely to be unemployed or be in unstable or badly paid employment. Vietnam is a case in point where its minority ethnic young people face relatively low rates of employment, wages, job ...
Luong, Minh Phuong, Wall, Tony, Hindley, Ann, Ngo, Nga, Ho, Thi Hanh Tien   +4 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Ethnic Minority Immigrants and their Children in Britain [PDF]

According to the 2001 UK Census ethnic minority groups account for 4.6 million or 7.9 percent of the total UK population. The 2001 British Labour Force Survey indicates that the descendants of Britain's ethnic minority immigrants form an important part ...
Nikolaos Theodoropoulos, Christian Dustmann   +1 more
core  

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Segregation and the Attainment of Minority Ethnic Pupils in England [PDF]

In this paper we ask whether ethnic segregation in schools and in neighbourhoods has a causal effect on differential school attainment. We ask two related but different questions.
Simon Burgess, Adam Briggs, Anete Piebalga, Deborah Wilson   +3 more
core  

Explaining the Ethnic Minority Disadvantage in Subjective Well-Being: A Multilevel Analysis of European Countries [PDF]

, 2015
In this study we try to explain the difference in subjective well-being between citizens who self-identify as a member of an ethnic minority group and citizens who describe themselves as a member of the majority population.
Thomas de Vroome, de Vroome, T.M., Marc Hooghe, Hooghe, Marc, Leerstoel Verkuijten, Migration, Cultural Diversity and Ethnic Relation, Maggino, Filomena   +6 more
core   +2 more sources