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Enantioselective inhibition of human CYP2C19 by the chiral pesticide ethofumesate: Prediction of pesticide-drug interactions in humans

open access: yesChemico-Biological Interactions, 2021
Ethofumesate is a chiral herbicide that may display enantioselective behavior in humans. For this reason, the enantioselective potential of ethofumesate and its main metabolite ethofumesate-2-hydroxy to cause pesticide-drug interactions on cytochrome ...
Icaro Salgado Perovani   +2 more
exaly   +2 more sources

Toxicity and bioaccumulation of ethofumesate enantiomers in earthworm Eisenia fetida [PDF]

open access: yesChemosphere, 2014
Earthworms represent an important food source for many vertebrates and as a result, predators may encounter toxic effects via the food chain from consumption of contaminated worms. Therefore, including an assessment of xenobiotic to worms in risk assessment procedures is advisable.
Yinghuan Wang, Huili Wang
exaly   +3 more sources
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Stereoselective degradation of ethofumesate in turfgrass and soil

Pesticide Biochemistry and Physiology, 2005
Abstract The stereoselective degradation of ethofumesate in turfgrasses and several agricultural soils was investigated to provide details of the fate of this chiral herbicide. Racemic ethofumesate was either foliar applied to two species of turfgrass or fortified into four types of agricultural soils.
Peng Wang, Jing Qiu
exaly   +2 more sources

Stereoselective toxicokinetics and tissue distribution of ethofumesate in rabbits

Chirality, 2007
AbstractThe stereoselective toxicokinetics of ethofumesate enantiomers following a single intravenous (i.v.) administration at doses of 30 mg/kg were investigated in rabbits. Plasma concentrations of (+)‐ and (−)‐ethofumesate were analyzed by a validated chiral HPLC method that involved extraction of plasma with organic solvent followed by separation ...
Wentao Zhu, Ziheng Dang, Jing Qiu
exaly   +3 more sources

Persistence and movement of ethofumesate in soil*

Weed Research, 1976
Summary:Persistence of ethofumesate [(±)2‐ethoxy‐2.3‐dihydro‐3,3‐dimethylbenzofuran‐5‐yl‐methansulphonate] in soil was associated with soil temperature. Ethofumesate applied at 4.5 kg/ha in November persisted about twice as long in soil as that applied the following March. In another field study, 88–91% of the herbicide had dissipated after 24 weeks in
E E Schweizer
exaly   +2 more sources

Influence of soil properties on ethofumesate mobility

Journal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural Wastes, 1993
Abstract We studied the mobility of ethofumesate (2‐ethoxy‐2,3‐dihydro‐3,3‐dimethylbenzofuran‐5‐yl methanesulphonate) in 23 soil samples by using soil thin layer chromatography (soil TLC) and soil‐packed columns. Eighteen of the samples assayed were from agricultural soils of the Marismas del Guadalquivir (a marshy region at the mouth of River ...
M Sánchez-Camazano   +1 more
exaly   +2 more sources

Adsorption of ethofumesate by agricultural and natural soils

Weed Research, 1993
Summary: Résumé: ZusammenfassungA study has been made of the effect of properties and composition of soils on the adsorption of ethofumesate. Adsorption isotherms of ethofumesate by agricultural and natural soils and by montmorillonite and humic acid were obtained.
M. J. SÁNCHEZ‐MARTIN   +2 more
openaire   +1 more source

Synthesis and use of pentadeuteroethyl ethofumesate as an internal standard for the determination of ethofumesate and its metabolites in water by gas chromatography-mass spectrometry

Journal of Chromatography A, 1994
Abstract Pentadeuteroethyl ethofumesate (ETO-d 5 ) was synthesized starting by acid hydrolysis of ethofumesate to 2,3-dihydro-2-hydroxy-3,3-dimethylbenzofuran-5-yl methanesulionate (ETO-OH) and successive ethylation with iodoethane-d 5 . This deuterated compound was used as an internal standard for the determination by gas chromatography-mass ...
Emilio Benfenati, Gaetano Facchini
exaly   +2 more sources

Ethofumesate applied at greater than labeled rates postemergence to sugarbeet

Weed Technology, 2023
AbstractEthofumesate is a broad-spectrum, soil-applied herbicide used to control broadleaf and grass weeds in sugarbeet crops. Ethofumesate is commonly applied preemergence at rates ranging from 1.25 to 4.2 kg ai ha−1, or applied postemergence (POST), up to 0.38 kg ai ha−1.
Alexa L. Lystad, Thomas J. Peters
openaire   +1 more source

Mobility and Dissipation of Ethofumesate and Halofenozide in Turfgrass and Bare Soil

Journal of Agricultural and Food Chemistry, 2001
The effect of turfgrass cover on the leaching and dissipation of ethofumesate and halofenozide was studied. Sampling cylinders (20 cm diam. x 30 cm long) were placed vertically in plots of creeping bentgrass (Agrostis palustris Huds.), tall fescue (Festuca arundinaceae Schreb.), or bare soil.
D S, Gardner, B E, Branham
openaire   +2 more sources

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