Results 41 to 50 of about 2,792,141 (258)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Determination of EDTA in dairy wastewater and adjacent surface water [PDF]

, 2010
An HPLC-UV analytical method was developed to determine ethylenediaminetetraacetic acid (EDTA) in dairy wastewater and surface water. The optimizing separation was achieved by reversed–phase ion-pair liquid chromatography on a C18 column using methanol ...
Xie, Congmin Zoe, Healy, Terry R., Robinson, Peter, Stewart, Kevin   +3 more
core  

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Ethylenediaminetetraacetic Acid Inhibits Vibrio Vulnificus-Induced Dendritic Cell Apoptosis by Lowering [Ca2+]i

Neurosignals, 2018
Background/Aims: Vibrio vulnificus (V. vulnificus) is a Gram-negative marine bacterium that can cause life-threatening primary septicemia, especially in the innate immune system. But how V.
Ping Qian, Bo Hu, Yuzhang Zhu, Dongliang Shao, Huaifeng Zhang, Huafei Huang, Lizhong Wang, Ruilin Shen   +7 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Efficacy of Removal of Iodoform Based Intracanal Medicament from Root Canals Using Peracetic Acid, Sodium Hypochlorite, And Ethylenediaminetetraacetic Acid as Irrigating Solutions in Teeth with Closed Apex – An In-Vitro Stereomicroscopic Study. [PDF]

, 2023
Aim: Removal of intracanal medicament is an ideal requirement for achieving a hermetic seal after obturation. These study aims to compare the efficacy of 0.5% peracetic acid, 3% sodium hypochlorite, and 17% ethylenediaminetetraacetic acid as irrigating ...
Mona Somani, Sweety Thumari, Aashray Patel, Mustafa Hajori, Chintan Joshi, Neelam Desai, Applu Atrey
core   +1 more source

Comparison of low-molecular-weight organic acids and ethylenediaminetetraacetic acid to enhance phytoextraction of heavy metals by maize [PDF]

, 2014
We compared acetic, ascorbic, and oxalic acids with ethylenediaminetetraacetic acid (EDTA) to enhance phytoextraction of nickel (Ni), manganese (Mn), zinc (Zn), copper (Cu), cadmium (Cd), and lead (Pb) by maize. Except ascorbic acid, acids significantly (
Aziz, Tariq, Zia-ur-Rehman, Muhammad, Ahmad, Hamaad Raza, Sabir, Muhammad, Musa, Mohamed Hanafi, Hakeem, Khalid Rehman, Saifullah,   +6 more
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

The Effectiveness of Chelating Solutions and Photodynamic Therapy in Inactivating Bacterial Lipopolysaccharides During Endodontic Therapy

European Endodontic Journal
Objective: The purpose of this study was to evaluate the influence effects of different endodontic treatments –, such as chelation ng solutions and antimicrobial photodynamic therapy (aPDT), on the rreductionng the amount of endotoxin levels in root ...
Denise Ferracioli Oda, Mirela Cesar Barros, Talita Tartari, Felipe Eduardo de Oliveira Silva, Christiane Becari Ribeiro, Luciane Dias De Oliveira, Flaviana Bombarda De Andrade   +6 more
doaj   +1 more source