Results 41 to 50 of about 2,614,577 (295)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Efficacy of Removal of Iodoform Based Intracanal Medicament from Root Canals Using Peracetic Acid, Sodium Hypochlorite, And Ethylenediaminetetraacetic Acid as Irrigating Solutions in Teeth with Closed Apex – An In-Vitro Stereomicroscopic Study. [PDF]

, 2023
Aim: Removal of intracanal medicament is an ideal requirement for achieving a hermetic seal after obturation. These study aims to compare the efficacy of 0.5% peracetic acid, 3% sodium hypochlorite, and 17% ethylenediaminetetraacetic acid as irrigating ...
Mona Somani, Sweety Thumari, Aashray Patel, Mustafa Hajori, Chintan Joshi, Neelam Desai, Applu Atrey
core   +1 more source

Ethylenediaminetetraacetic Acid Inhibits Vibrio Vulnificus-Induced Dendritic Cell Apoptosis by Lowering [Ca2+]i

Neurosignals, 2018
Background/Aims: Vibrio vulnificus (V. vulnificus) is a Gram-negative marine bacterium that can cause life-threatening primary septicemia, especially in the innate immune system. But how V.
Ping Qian, Bo Hu, Yuzhang Zhu, Dongliang Shao, Huaifeng Zhang, Huafei Huang, Lizhong Wang, Ruilin Shen   +7 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Comparison of the effect of citric acid and ethylenediaminetetraacetic acid on regenerative endodontic outcomes: A systematic review protocol

, 2023
In regenerative endodontics, clinical guidelines recommend the use of chelating agents, such as ethylenediaminetetraacetic acid (EDTA) to release bioactive molecules entrapped in the dentin matrix during dentin demineralization (American Association of ...
Gabriel Pereira Nunes, Francine Benetti, Lucas Guimarães Abreu, Pedro Augusto Pereira dos Santos, Priscila Toninatto Alves de Toledo, Alexandre Henrique dos Reis-Prado, Renan Dal Fabbro   +6 more
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

The Effectiveness of Chelating Solutions and Photodynamic Therapy in Inactivating Bacterial Lipopolysaccharides During Endodontic Therapy

European Endodontic Journal
Objective: The purpose of this study was to evaluate the influence effects of different endodontic treatments –, such as chelation ng solutions and antimicrobial photodynamic therapy (aPDT), on the rreductionng the amount of endotoxin levels in root ...
Denise Ferracioli Oda, Mirela Cesar Barros, Talita Tartari, Felipe Eduardo de Oliveira Silva, Christiane Becari Ribeiro, Luciane Dias De Oliveira, Flaviana Bombarda De Andrade   +6 more
doaj   +1 more source

An in vitro study to evaluate the demineralizing effect of maleic acid and cell attachment on cemental surface

Saudi Endodontic Journal, 2017
Introduction: Root biomodifying agents are adjuncts to periodontal regeneration. Aim: This study evaluates the demineralization effect of a chelating agent, maleic acid (MA) when used as a root biomodifier on the cemental surface. Materials and Methods:
Jothi Varghese, Nidambur Vasudev Ballal
doaj   +1 more source