Results 181 to 190 of about 1,956,484 (356)

Polyhalogenated Carbazole Impairs Dopaminergic Neurons through Dysregulation of Liquid–Liquid Phase Separation in Caenorhabditis elegans

Advanced Science, EarlyView.
Polyhalogenated carbazoles (PHCZ), persistent environmental contaminants, preferentially accumulate in neuronal tissues. Studies using Caenorhabditis elegans and human neuronal cell lines reveal that PHCZ induce dopaminergic neurodegeneration by promoting liquid–liquid phase separation of α‐synuclein, reducing condensate fluidity, impairing ...
Yuhang Luo, Hongbo Xu, Pei Peng, Xinhe Lu, Qian Zhou, Ziqing Gao, Cheng Tang, Hongyan Yin, Ying Cai, Gaga Mahai, Zhiqiang Zhu, Zuojun Liu, Hanzeng Li, Shunqing Xu   +13 more
wiley   +1 more source

Synergistic Modulation of Microglial Polarization by Acteoside and Ferulic Acid via Dual Targeting of Nrf2 and RORγt to Alleviate Depression‐Associated Neuroinflammation

Advanced Science, EarlyView.
Machine‐learning‐directed phytochemical pair ACT/FA, administered at BDD's orthodox ratio, synergistically modulates microglial polarization via dual Nrf2/RORγt targeting to attenuate neuroinflammation and depressive behaviors. This concentration‐dependent synergism replicates the parent formula's efficacy while providing a mechanistic basis for ...
Dongjing Guo, Qiancheng Mao, Xinyu Fang, Liuxuan Huang, Haoquan Tian, Wenguang Yang, Feiyue Zhou, Ke Ma   +7 more
wiley   +1 more source

Transient elastography compared to liver biopsy and morphometry for predicting fibrosis in pediatric chronic liver disease: Does etiology matter?

, 2016
Behairy El-Sayed Behairy, Mostafa Mohamed Sıra, Khaled Zalata, El-Sayed Ebrahem Salama, Mohamed Abdallah   +4 more
openalex   +2 more sources

Etiology of hyperparathyroidism and bone disease during chronic hemodialysis [PDF]

, 1971
Albert Fournier, Claude D. Arnaud, William J. Johnson, William F. Taylor, Ralph S. Goldsmith   +4 more
openalex   +1 more source

Wheezing of unexpected etiology: A case report of pea aspiration mimicking bronchus obstruction caused by a tumor

, 2021
Hirotada Muramatsu, Akira Kuriyama
openalex   +1 more source

Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia.

Journal of the American Medical Directors Association, 2011
R. Fielding, B. Vellas, W. Evans, S. Bhasin, J. Morley, A. Newman, G. Abellán van Kan, S. Andrieu, J. Bauer, D. Breuillé, T. Cederholm, J. Chandler, C. de Meynard, L. Donini, T. Harris, A. Kannt, Florence Keime Guibert, G. Onder, D. Papanicolaou, Y. Rolland, D. Rooks, C. Sieber, E. Souhami, S. Verlaan, M. Zamboni   +24 more
semanticscholar   +1 more source

Single‐Cell Transcriptomics Reveals ITGA2‐Mediated Metabolic Reprogramming and Immune Crosstalk in Pediatric Thyroid Carcinogenesis

Advanced Science, EarlyView.
This study unveils ITGA2⁺ tumor cells as key drivers of pediatric thyroid cancer aggressiveness. These cells orchestrate dual oncogenic pathways: GLUT1‐mediated glycolytic reprogramming and M2 macrophage polarization. This metabolic‐immunological crosstalk promotes tumor progression and metastasis.
Zhi‐jun Zhan, Ning Li, Yan Sun, Lu Chen, Jun‐da Yin, Yun‐han Shan, Jia‐xing Zeng, Zhe‐cheng Li, Hai‐long Tan, Neng Tang, Shi Chang, Peng Huang   +11 more
wiley   +1 more source

Impact of Etiology of Cirrhosis on the Survival of Patients Diagnosed With Hepatocellular Carcinoma During Surveillance. CME

, 2007
Franco Trevisani, Giulia Magini, Valentina Santi, Antonio Maria Morselli‐Labate, Maria Chiara Cantarini, Maria Anna Di Nolfo, P. Del Poggio, Luisa Benvegnù, Gianludovico Rapaccini, Fabio Farinati, Marco Zoli, Franco Borzio, Edoardo G. Giannini, Eugenio Caturelli, Mauro Bernardi   +14 more
openalex   +2 more sources

Single‐Nucleus RNA Sequencing Reveals Mid‐Gestational Neurodevelopment Features in the Superior Temporal Plane from Fetuses with Nonsyndromic Cleft Lip and Palate

Advanced Science, EarlyView.
Single‐nucleus RNA sequencing of mid‐gestation brains from fetuses with nonsyndromic cleft lip and palate reveals major disruptions in cell composition, cell‐to‐cell signaling, and gene regulation. The transcription factor MEF2C is identified as a central regulator of these changes and shows that lowering MEF2C impairs synapse formation, linking cleft ...
Liu‐Lin Xiong, Xin‐Wei Huang, Qiu‐Xia Xiao, Ying‐Gang Zheng, Hao‐Yue Qin, Chang‐Le Fang, Li Chen, Ruo‐Lan Du, Qiu‐Lin Wang, Li‐Ren Huangfu, Ye‐Qing Fei, Yang‐Yang Zhao, Chen‐Yang Zhai, Ze‐Mian Chen, Shi‐Kun Yuan, Yu‐Ji Zhou, Xing‐Man He, Ting‐Ting Zhi, Xiao‐He Tian, Ting‐Hua Wang   +19 more
wiley   +1 more source

Analyses of Etiologic and Sociodemografic Properties of the Intoxicated Cases in Van City and its Environs [PDF]

, 2012
Hayriye Gönüllü
openalex   +1 more source