Results 191 to 200 of about 889,444 (319)

Carotid Perivascular Adipose Tissue Density as a Marker of Large Artery Atherosclerotic Stroke in Patients Undergoing Mechanical Thrombectomy for Acute Middle Cerebral Artery Occlusion. [PDF]

J Clin Med
Genez S, Atasoy SN, Mustak U, Özer H, Yılmazsoy Y, Öğün MN, Tokmak H, Yılmaz M, Ersoy S.   +8 more
europepmc   +1 more source

Master Regulator SMC1A, Stabilized by N6‐Methyladenosine Reader IGF2BP1, Promotes HCC Progression Through Facilitating Enhancer–Promoter Interaction of Nestin

Advanced Science, EarlyView.
IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng, Diguang Wen, Lu Zeng, Lin Lv, Shengtao Liao, Wenguang Zhang, Zhechuan Mei, Chuanfei Li   +7 more
wiley   +1 more source

Peritoneal drainage versus primary laparotomy in premature newborns with intestinal perforation: a retrospective cohort study evaluating an etiology-driven surgical approach. [PDF]

BMC Surg
Shalaby MM, Negm AR, Mahran IA, Shehata M, Awad M.   +4 more
europepmc   +1 more source

Targeting Dnmt3a/m5C/RelA Axis Attenuates Microglia Inflammatory Response and Improves Postoperative Recovery in Chronic Compressive Cervical Spinal Cord Injury

Advanced Science, EarlyView.
A pro‐inflammatory microglial subset persists after decompression in chronic compressive cervical spinal cord injury and shows enhanced Dnmt3a‐driven m5C signaling. By stabilizing RelA mRNA, this axis sustains NF‐κB activation and postoperative neuroinflammation.
Tianyu Qin, Yuan Jiang, Yongheng Xie, Huanwei Qu, Wenbin Yan, Jingle Chen, Yining Chen, Huayi Li, Naibo Feng, Jiajun Wu, Chao Zhang, Zhengqi Huang, Ming Shi, Zhihuai Deng, Guozhi Xiao, Houqing Long   +15 more
wiley   +1 more source

Etiology of Poliomyelitis [PDF]

BMJ, 1911
openaire   +2 more sources

PRMT9 Aggravated Dopaminergic Neurodegeneration in Parkinson's Disease Model by Facilitating the Degradation of DUSP26 and Inducing Mitochondrial Dysfunction

Advanced Science, EarlyView.
In the pathological state of PD induced by MPP+, the upregulated PRMT9 in dopaminergic neurons translocates into mitochondrion and interacts with DUSP26 and catalyzes its arginine methylation, leading to the ubiquitin‐proteasomal degradation of DUSP26 mediated by Trim32.
Tengfei Liu, Xiaomeng Song, Xin Guo, Rui Xiao, Ru Sun, Qiuran Ji, Lu Yu, Yiquan Li, Qingyi Fu, Qidi Xue, Lingjun Kong, Lin Chen, Chengjiang Gao, Huiqing Liu   +13 more
wiley   +1 more source

Etiology of cardiovascular disease in patients with schizophrenia: current perspectives

, 2015
Murat Emul,1 Tevfik Kalelioglu21Department of Psychiatry, Medical School of Cerrahpasa, Istanbul University, 2Department of Psychiatry, Bakirkoy Mental Health Research and Training Hospital, Istanbul, TurkeyAbstract: Cardiovascular morbidity and ...
Kalelioglu T, Emul M
core  

Human Urine Stem Cells Alleviate Pulmonary Fibrosis via Inhibiting Macrophage‐Myofibroblast Transition

Advanced Science, EarlyView.
Therapeutic role and mechanism of human urine stem cells (hUSCs) in pulmonary fibrosis. hUSCs alleviated pulmonary fibrosis by selectively inhibiting macrophage‐myofibroblast transition (MMT) in two ways: on one hand, hUSCs inhibited mitochondrial reactive oxygen species (mtROS) production and apoptosis/senescence of epithelial cells in pulmonary ...
Zhou‐Hang Zhang, Guan‐Lin Guo, Xiao‐Hui Guan, Min Hu, Qi‐Ming Huang, Ding‐Wen Guo, Hao‐Cheng Gu, You‐Qiong Zhuo, Ning Li, Hong‐Bo Xin, Ke‐Yu Deng   +10 more
wiley   +1 more source

The doctrine of specific etiology [PDF]

Modern medicine is often said to have originated with 19th century germ theory, which attributed diseases to particular bacterial contagions. The success of this theory is often associated with an underlying principle referred to as the "doctrine of ...
Ross, Lauren N.
core  

Mood Disorder Begins in the Mouth: Periodontitis Mediates Anxiety‐Like Behaviors

Advanced Science, EarlyView.
ABSTRACT The previous study elucidated that the C‐reactive protein (CRP)/bone morphogenetic protein 4 (BMP4) signaling pathway mediates periodontitis‐associated anxiety‐like behaviors in rats. This molecular crosstalk along the periodontal‐hippocampal axis provides novel insights into the etiology and mechanisms of emotional disorders. However, several
Zhigang Chen, Xing Li
wiley   +1 more source