Breaking Latent Infection: How ORF37/38-Deletion Mutants Offer New Hope against EHV-1 Neuropathogenicity [PDF]
VirusesEquid alphaherpesvirus 1 (EHV-1) has been linked to the emergence of neurological disorders, with the horse racing industry experiencing significant impacts from outbreaks of equine herpesvirus myeloencephalopathy (EHM).
Si-Yu Zhang +2 more
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Fibroblast growth factor receptor inhibitors mitigate the neuropathogenicity of Borrelia burgdorferi or its remnants ex vivo [PDF]
Frontiers in ImmunologyIn previous studies, we showed that fibroblast growth factor receptors (FGFRs) contribute to inflammatory mediator output from primary rhesus microglia in response to live Borrelia burgdorferi. We also demonstrated that non-viable B.
Geetha Parthasarathy +1 more
exaly +4 more sources
Do SARS-CoV-2 Variants Differ in Their Neuropathogenicity? [PDF]
mBio, 2023 Neurological complications associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are a huge societal problem. Although the neuropathogenicity of SARS-CoV-2 is not yet fully understood, there is evidence that SARS-CoV-2 ...
Lisa Bauer, Debby van Riel
doaj +2 more sources
A Recombinant System and Reporter Viruses for Papiine Alphaherpesvirus 2 [PDF]
Viruses, 2022 Primate simplex viruses, including Herpes simplex viruses 1 and 2, form a group of closely related herpesviruses, which establish latent infections in neurons of their respective host species.
Abdul Rahman Siregar +7 more
doaj +2 more sources
Neuro-Ophthalmic Dengue Infection: A Case Report with a Multiple Body Site Sampling Strategy and Review of Laboratory Data [PDF]
VirusesDengue neurological disease is an uncommon yet severe complication of dengue infection. It can manifest as encephalitis, encephalopathy, neuro-ophthalmic complications, or neuromuscular disorders.
Grace I. Butel-Simoes +11 more
doaj +2 more sources
Multiple Receptors Involved in Invasion and Neuropathogenicity of Canine Distemper Virus: A Review
Viruses, 2022 The canine distemper virus (CDV) is a morbillivirus that infects a broad range of terrestrial carnivores, predominantly canines, and is associated with high mortality.
Jianjun Zhao
exaly +3 more sources
A Point Mutation in a Herpesvirus Co-Determines Neuropathogenicity and Viral Shedding
Viruses, 2017 A point mutation in the DNA polymerase gene in equine herpesvirus type 1 (EHV-1) is one determinant for the development of neurological disease in horses.
Mathias Franz +2 more
exaly +3 more sources
Discordant imaging findings in dizygotic twins with known exposure to maternal ZIKV infection during initial stages of pregnancy [PDF]
IDCasesZika virus (ZIKV) is an arbovirus commonly transmitted to humans through the bite of an infected Aedes mosquito. Clinically, ZIKV is known to cause a wide range of symptoms, from febrile rash to severe neurological conditions, with congenital ...
Fabio Adami-Teppa +7 more
doaj +2 more sources
Conserved non-coding RNA motifs influence the neuropathogenicity of Simbuviruses: Molecular dissection in the Schmallenberg virus model [PDF]
PLoS PathogensThe Simbu serogroup, part of the Peribunyaviridae family, includes arboviruses associated with febrile illnesses in humans and fetal congenital malformations due to viral neurotropism in ruminants.
Laura Bonil +7 more
doaj +3 more sources
Neuropathogenicity of Two Saffold Virus Type 3 Isolates in Mouse Models [PDF]
PLoS ONE, 2016 Saffold virus (SAFV), a picornavirus, is occasionally detected in children with acute flaccid paralysis, meningitis, and cerebellitis; however, the neuropathogenicity of SAFV remains undetermined.The virulence of two clinical isolates of SAFV type 3 ...
Asif Naeem +2 more
exaly +2 more sources