Results 11 to 20 of about 805 (153)

A point mutation in a herpesvirus polymerase determines neuropathogenicity. [PDF]

PLoS Pathogens, 2007
Infection with equid herpesvirus type 1 (EHV-1) leads to respiratory disease, abortion, and neurologic disorders in horses. Molecular epidemiology studies have demonstrated that a single nucleotide polymorphism resulting in an amino acid variation of the
Laura B Goodman, Arianna Loregian, Gillian A Perkins, Josie Nugent, Elizabeth L Buckles, Beatrice Mercorelli, Julia H Kydd, Giorgio Palù, Ken C Smith, Nikolaus Osterrieder, Nicholas Davis-Poynter   +10 more
doaj   +7 more sources

Langat Virus Biology and Infection. [PDF]

Rev Med Virol
ABSTRACT Flaviviruses pose a major threat to global health and can cause severe disease in animals and humans. Among them, tick‐borne encephalitis virus (TBEV) and related members of the tick‐borne encephalitis (TBE) serocomplex are transmitted primarily by ticks and can lead to neurological disease, including encephalitis and death. Despite many years
Klestova Z, Sauter D, Schindler M, Iftner T.   +3 more
europepmc   +2 more sources

Neuropathogenicity of non-viable Borrelia burgdorferi ex vivo [PDF]

Scientific Reports, 2022
Even after appropriate treatment, a proportion of Lyme disease patients suffer from a constellation of symptoms, collectively called Post-Treatment Lyme Disease Syndrome (PTLDS).
Geetha Parthasarathy, Shiva Kumar Goud Gadila   +1 more
doaj   +3 more sources

Cross-Section of Neurological Manifestations Among SARS-CoV-2 Omicron Subvariants—Single-Center Study [PDF]

Brain Sciences
Background/Objectives: The Omicron variant of SARS-CoV-2 is undergoing constant mutation. New strains vary in neuropathogenicity and the neurological spectrum of disease.
Justyna Jachman-Kapułka, Aleksander Zińczuk, Krzysztof Simon, Marta Rorat   +3 more
doaj   +2 more sources

Combined mutations in nonstructural protein 14, envelope, and membrane proteins mitigate the neuropathogenicity of SARS-CoV-2 Omicron BA.1 in K18-hACE2 mice [PDF]

mSphere
We previously reported that mutations outside the spike protein play a role in the attenuation of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.1 variant in human ACE2 transgenic mice (K18-hACE2).
Kotou Sangare, Shufeng Liu, Prabhuanand Selvaraj, Charles B. Stauft, Matthew F. Starost, Tony T. Wang   +5 more
doaj   +2 more sources

Amino acid changes accumulated in the fusion protein allow neuropathogenic measles viruses to use a broad repertoire of host factors for cell fusion triggering [PDF]

Journal of Virology
Measles virus (MeV), an enveloped RNA virus belonging to the genus Morbillivirus of the family Paramyxoviridae, is the causative agent of measles, an acute febrile illness with skin rash. MeV has two types of envelope glycoproteins: the hemagglutinin (H)
Yuichi Hirai, Ryuichi Takemoto, Yusuke Yanagi, Yuta Shirogane   +3 more
doaj   +2 more sources

Identification of neuropathogenic Varicellovirus equidalpha1 as a potential cause of respiratory disease outbreaks among horses in North Xinjiang, China, from 2021-2023 [PDF]

BMC Veterinary Research
Background Varicellovirus equidalpha1 (formerly Equid alphaherpesvirus 1, EqAHV-1) is among the most important viruses responsible for respiratory disease outbreaks among horses throughout the world.
Panpan Tong, Enhui Yang, Bin Liu, Shuyao tian, Youtu Suo, JuanJuan Pan, Yueyi Dang, Nuerlan Palidan, Chenyang Jia, Ling Kuang, Jinxin Xie   +10 more
doaj   +2 more sources

SARS-CoV-2 Omicron Variants Show Attenuated Neurovirulence Compared with the Wild-Type Strain in Elderly Human Brain Spheroids [PDF]

Research
Infection with severe acute respiratory syndrome coronavirus 2 Omicron variants still causes neurological complications in elderly individuals. However, whether and how aging brains are affected by Omicron variants in terms of neuroinvasiveness and ...
Weikang Chen, Xiaobing Jiang, Wei Liang, Haojie Bai, Mingze Xu, Zhe Liu, Lina Yi, Yanming Liu, Yanxia Huang, Yongxin Zhang, Lixia Xu, Baoshu Xie, Nu Zhang, Jun Yu, Jing Lu, Haipeng Xiao, Xiaoxing Li   +16 more
doaj   +2 more sources

Interaction of the Hemagglutinin Stalk Region with Cell Adhesion Molecule (CADM) 1 and CADM2 Mediates the Spread between Neurons and Neuropathogenicity of Measles Virus with a Hyperfusogenic Fusion Protein [PDF]

Journal of Virology, 2023
Tateki Suzuki, Takao Hashiguchi, Yusuke Yanagi   +2 more
exaly   +2 more sources

M protein of subacute sclerosing panencephalitis virus, synergistically with the F protein, plays a crucial role in viral neuropathogenicity [PDF]

Journal of General Virology, 2021
Miho Konami, Kento Sakamoto, Yoshinori Kitagawa   +2 more
exaly   +2 more sources