Results 11 to 20 of about 1,031 (173)

A point mutation in a herpesvirus polymerase determines neuropathogenicity. [PDF]

PLoS Pathogens, 2007
Infection with equid herpesvirus type 1 (EHV-1) leads to respiratory disease, abortion, and neurologic disorders in horses. Molecular epidemiology studies have demonstrated that a single nucleotide polymorphism resulting in an amino acid variation of the
Laura B Goodman, Arianna Loregian, Gillian A Perkins, Josie Nugent, Elizabeth L Buckles, Beatrice Mercorelli, Julia H Kydd, Giorgio Palù, Ken C Smith, Nikolaus Osterrieder, Nicholas Davis-Poynter   +10 more
doaj   +9 more sources

Study of Usutu virus neuropathogenicity in mice and human cellular models.

PLoS Neglected Tropical Diseases, 2020
Usutu virus (USUV), an African mosquito-borne flavivirus closely related to West Nile virus, was first isolated in South Africa in 1959. USUV emerged in Europe two decades ago, causing notably massive mortality in Eurasian blackbirds.
Marion Clé, Jonathan Barthelemy, Caroline Desmetz, Vincent Foulongne, Lina Lapeyre, Karine Bolloré, Edouard Tuaillon, Nejla Erkilic, Vasiliki Kalatzis, Sylvie Lecollinet, Cécile Beck, Nelly Pirot, Yaël Glasson, Fabien Gosselet, Maria Teresa Alvarez Martinez, Philippe Van de Perre, Sara Salinas, Yannick Simonin   +17 more
doaj   +2 more sources

Visna Virus dUTPase Is Dispensable for Neuropathogenicity [PDF]

Journal of Virology, 1998
ABSTRACT The major part of the dUTPase-encoding region of the visna virus genome was deleted. Intracerebral injection of the mutant virus resulted in a somewhat reduced viral load compared to that resulting from injection of the wild type, especially in the lungs, but the neuropathogenic effects were comparable.
Petursson, G, Turelli, P, Matthiasdottir, S, Georgsson, G, Andresson, OS, Torsteinsdottir, S, Vigne, R, Andresdottir, V, Gunnarsson, E, Agnarsdottir, G, Querat, G   +10 more
openaire   +3 more sources

Langat Virus Biology and Infection. [PDF]

Rev Med Virol
ABSTRACT Flaviviruses pose a major threat to global health and can cause severe disease in animals and humans. Among them, tick‐borne encephalitis virus (TBEV) and related members of the tick‐borne encephalitis (TBE) serocomplex are transmitted primarily by ticks and can lead to neurological disease, including encephalitis and death. Despite many years
Klestova Z, Sauter D, Schindler M, Iftner T.   +3 more
europepmc   +2 more sources

Study of BBB Dysregulation in Neuropathogenicity Using Integrative Human Model of Blood–Brain Barrier

Frontiers in Cellular Neuroscience, 2022
The blood–brain barrier (BBB) is a cellular and physical barrier with a crucial role in homeostasis of the brain extracellular environment. It controls the imports of nutrients to the brain and exports toxins and pathogens.
Coraly Simöes Da Gama, Mélanie Morin-Brureau   +1 more
exaly   +3 more sources

Neuropathogenicity of non-viable Borrelia burgdorferi ex vivo [PDF]

Scientific Reports, 2022
Even after appropriate treatment, a proportion of Lyme disease patients suffer from a constellation of symptoms, collectively called Post-Treatment Lyme Disease Syndrome (PTLDS).
Geetha Parthasarathy, Shiva Kumar Goud Gadila   +1 more
doaj   +3 more sources

Development of Polioencephalomyelitis in Cesarean-Derived Colostrum-Deprived Pigs Following Experimental Inoculation with Either Teschovirus A Serotype 2 or Serotype 11

Viruses, 2017
Teschovirus encephalomyelitis is a sporadic disease associated with Teschovirus A (PTV) serotype 1 and, less frequently, other serotypes. In recent years, the number of cases submitted to the Iowa State University Veterinary Diagnostic Laboratory with a ...
Franco Matias Ferreyra, Bailey Arruda, Gregory Stevenson, Kent Schwartz, Darin Madson, Kyoung-Jin Yoon, Jianqiang Zhang, Pablo Piñeyro, Qi Chen, Paulo Arruda   +9 more
doaj   +2 more sources

Changes in transmission of Enterovirus D68 (EV-D68) in England inferred from seroprevalence data [PDF]

eLife, 2023
The factors leading to the global emergence of Enterovirus D68 (EV-D68) in 2014 as a cause of acute flaccid myelitis (AFM) in children are unknown. To investigate potential changes in virus transmissibility or population susceptibility, we measured the ...
Margarita Pons-Salort, Ben Lambert, Everlyn Kamau, Richard Pebody, Heli Harvala, Peter Simmonds, Nicholas C Grassly   +6 more
doaj   +2 more sources

Cross-Section of Neurological Manifestations Among SARS-CoV-2 Omicron Subvariants—Single-Center Study [PDF]

Brain Sciences
Background/Objectives: The Omicron variant of SARS-CoV-2 is undergoing constant mutation. New strains vary in neuropathogenicity and the neurological spectrum of disease.
Justyna Jachman-Kapułka, Aleksander Zińczuk, Krzysztof Simon, Marta Rorat   +3 more
doaj   +2 more sources

Necroptosis of neuronal cells is related to the neuropathology of tick-borne encephalitis [PDF]

Virus Research, 2022
Tick-borne encephalitis virus (TBEV) is a zoonotic virus that causes tick-borne encephalitis (TBE) in humans. Infections of Sapporo-17-Io1 (Sapporo) and Oshima 5-10 (Oshima) TBEV strains showed different pathogenic effects in mice.
Dai Tsujino, Kentaro Yoshii, Misa Kajiyama, Yuji Takahashi, Naoya Maekawa, Hiroaki Kariwa, Shintaro Kobayashi   +6 more
doaj   +2 more sources