A point mutation in a herpesvirus polymerase determines neuropathogenicity. [PDF]
PLoS Pathogens, 2007 Infection with equid herpesvirus type 1 (EHV-1) leads to respiratory disease, abortion, and neurologic disorders in horses. Molecular epidemiology studies have demonstrated that a single nucleotide polymorphism resulting in an amino acid variation of the
Laura B Goodman +10 more
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Neuropathogenicity of Two Saffold Virus Type 3 Isolates in Mouse Models. [PDF]
PLoS ONE, 2016 Saffold virus (SAFV), a picornavirus, is occasionally detected in children with acute flaccid paralysis, meningitis, and cerebellitis; however, the neuropathogenicity of SAFV remains undetermined.The virulence of two clinical isolates of SAFV type 3 ...
Osamu Kotani +12 more
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M Protein of Subacute Sclerosing Panencephalitis Virus, Synergistically With the F Protein, Plays a Crucial Role in Viral Neuropathogenicity [PDF]
Journal of General Virology, 2021 Yoshinori Kitagawa +2 more
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Study of Usutu virus neuropathogenicity in mice and human cellular models.
PLoS Neglected Tropical Diseases, 2020 Usutu virus (USUV), an African mosquito-borne flavivirus closely related to West Nile virus, was first isolated in South Africa in 1959. USUV emerged in Europe two decades ago, causing notably massive mortality in Eurasian blackbirds.
Marion Clé +17 more
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Changes in transmission of Enterovirus D68 (EV-D68) in England inferred from seroprevalence data [PDF]
eLife, 2023 The factors leading to the global emergence of Enterovirus D68 (EV-D68) in 2014 as a cause of acute flaccid myelitis (AFM) in children are unknown. To investigate potential changes in virus transmissibility or population susceptibility, we measured the ...
Margarita Pons-Salort +6 more
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Necroptosis of neuronal cells is related to the neuropathology of tick-borne encephalitis [PDF]
Virus Research, 2022 Tick-borne encephalitis virus (TBEV) is a zoonotic virus that causes tick-borne encephalitis (TBE) in humans. Infections of Sapporo-17-Io1 (Sapporo) and Oshima 5-10 (Oshima) TBEV strains showed different pathogenic effects in mice.
Dai Tsujino +6 more
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Functional Genomics and Immunologic Tools: The Impact of Viral and Host Genetic Variations on the Outcome of Zika Virus Infection [PDF]
Viruses, 2018 Zika virus (ZIKV) causes no-to-mild symptoms or severe neurological disorders. To investigate the importance of viral and host genetic variations in determining ZIKV infection outcomes, we created three full-length infectious cDNA clones as bacterial ...
Sang-Im Yun +8 more
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Paired immunoglobulin-like receptor B is an entry receptor for mammalian orthoreovirus
Nature Communications, 2023 Mammalian orthoreovirus (reovirus) infects most mammals and is associated with celiac disease in humans. In mice, reovirus infects the intestine and disseminates systemically to cause serotype-specific patterns of disease in the brain.
Pengcheng Shang +14 more
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Viruses, 2017 Teschovirus encephalomyelitis is a sporadic disease associated with Teschovirus A (PTV) serotype 1 and, less frequently, other serotypes. In recent years, the number of cases submitted to the Iowa State University Veterinary Diagnostic Laboratory with a ...
Franco Matias Ferreyra +9 more
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Neuropathogenicity of non-viable Borrelia burgdorferi ex vivo [PDF]
Scientific Reports, 2022 Even after appropriate treatment, a proportion of Lyme disease patients suffer from a constellation of symptoms, collectively called Post-Treatment Lyme Disease Syndrome (PTLDS).
Geetha Parthasarathy +1 more
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