Results 21 to 30 of about 1,031 (173)

Functional Genomics and Immunologic Tools: The Impact of Viral and Host Genetic Variations on the Outcome of Zika Virus Infection [PDF]

Viruses, 2018
Zika virus (ZIKV) causes no-to-mild symptoms or severe neurological disorders. To investigate the importance of viral and host genetic variations in determining ZIKV infection outcomes, we created three full-length infectious cDNA clones as bacterial ...
Sang-Im Yun, Byung-Hak Song, Jordan C. Frank, Justin G. Julander, Aaron L. Olsen, Irina A. Polejaeva, Christopher J. Davies, Kenneth L. White, Young-Min Lee   +8 more
doaj   +2 more sources

Combined mutations in nonstructural protein 14, envelope, and membrane proteins mitigate the neuropathogenicity of SARS-CoV-2 Omicron BA.1 in K18-hACE2 mice [PDF]

mSphere
We previously reported that mutations outside the spike protein play a role in the attenuation of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.1 variant in human ACE2 transgenic mice (K18-hACE2).
Kotou Sangare, Shufeng Liu, Prabhuanand Selvaraj, Charles B. Stauft, Matthew F. Starost, Tony T. Wang   +5 more
doaj   +2 more sources

Amino acid changes accumulated in the fusion protein allow neuropathogenic measles viruses to use a broad repertoire of host factors for cell fusion triggering [PDF]

Journal of Virology
Measles virus (MeV), an enveloped RNA virus belonging to the genus Morbillivirus of the family Paramyxoviridae, is the causative agent of measles, an acute febrile illness with skin rash. MeV has two types of envelope glycoproteins: the hemagglutinin (H)
Yuichi Hirai, Ryuichi Takemoto, Yusuke Yanagi, Yuta Shirogane   +3 more
doaj   +2 more sources

Identification of neuropathogenic Varicellovirus equidalpha1 as a potential cause of respiratory disease outbreaks among horses in North Xinjiang, China, from 2021-2023 [PDF]

BMC Veterinary Research
Background Varicellovirus equidalpha1 (formerly Equid alphaherpesvirus 1, EqAHV-1) is among the most important viruses responsible for respiratory disease outbreaks among horses throughout the world.
Panpan Tong, Enhui Yang, Bin Liu, Shuyao tian, Youtu Suo, JuanJuan Pan, Yueyi Dang, Nuerlan Palidan, Chenyang Jia, Ling Kuang, Jinxin Xie   +10 more
doaj   +2 more sources

SARS-CoV-2 Omicron Variants Show Attenuated Neurovirulence Compared with the Wild-Type Strain in Elderly Human Brain Spheroids [PDF]

Research
Infection with severe acute respiratory syndrome coronavirus 2 Omicron variants still causes neurological complications in elderly individuals. However, whether and how aging brains are affected by Omicron variants in terms of neuroinvasiveness and ...
Weikang Chen, Xiaobing Jiang, Wei Liang, Haojie Bai, Mingze Xu, Zhe Liu, Lina Yi, Yanming Liu, Yanxia Huang, Yongxin Zhang, Lixia Xu, Baoshu Xie, Nu Zhang, Jun Yu, Jing Lu, Haipeng Xiao, Xiaoxing Li   +16 more
doaj   +2 more sources

Interaction of the Hemagglutinin Stalk Region with Cell Adhesion Molecule (CADM) 1 and CADM2 Mediates the Spread between Neurons and Neuropathogenicity of Measles Virus with a Hyperfusogenic Fusion Protein [PDF]

Journal of Virology, 2023
Takao Hashiguchi, Yusuke Yanagi, Yuta Shirogane   +2 more
exaly   +2 more sources

M protein of subacute sclerosing panencephalitis virus, synergistically with the F protein, plays a crucial role in viral neuropathogenicity [PDF]

Journal of General Virology, 2021
Yoshinori Kitagawa, Bin Gotoh, Kento Sakamoto   +2 more
exaly   +2 more sources

Molecular Basis of Neuropathogenicity of Mouse Hepatitis Virus

, 1992
The JHM strain of mouse hepatitis virus (MHV), a member of the Coronaviridae, was one of the earliest recognized neurotropic viruses. It was isolated from a paralytic mouse by F. S. Cheever et al. in 1949 (1, 2), and subsequently shown to cause encephalitis and demyelinating lesions upon intracerebral injection into mice (1, 3, 4, 5).
Michael M. C. Lai, Stephen A. Stohlman
openaire   +2 more sources

Neuropathogenic human coronaviruses: A review

Reviews in Medical Virology, 2020
SummaryHuman Coronaviruses (HCoVs) have long been known as respiratory viruses. However, there are reports of neurological findings in HCoV infections, particularly in patients infected with the novel severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) amid Coronavirus disease 2019 (COVID‐19) pandemic.
Abdelaziz, Osama S., Waffa, Zuraiha
openaire   +3 more sources

Microglia and astrocyte responses to neuropathogenic protozoan parasites [PDF]

Faculty Reviews, 2021
Cerebral toxoplasmosis and cerebral malaria are two important neurological diseases caused by protozoan parasites. In this review, we discuss recent findings regarding the innate immune responses of microglia and astrocytes to Toxoplasma and Plasmodium infection. In both infections, these tissue-resident glial cells perform a sentinel function mediated
Nasuhidehnavi, Azadeh, Yap, George S
openaire   +2 more sources