A novel PCR protocol for detection and differentiation of neuropathogenic and non-neuropathogenic equid alphaherpesvirus 1 [PDF]
Journal of Veterinary Diagnostic Investigation, 2019 Equid alphaherpesvirus 1 (EHV-1) infections can have a major impact on the horse industry and equine welfare by causing abortion or respiratory or neurologic disease. A single nucleotide polymorphism (A 2254 →G 2254 ) in open reading frame (ORF) 30 ...
Lechmann, Julia +5 more
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Cross-Section of Neurological Manifestations Among SARS-CoV-2 Omicron Subvariants—Single-Center Study [PDF]
Brain SciencesBackground/Objectives: The Omicron variant of SARS-CoV-2 is undergoing constant mutation. New strains vary in neuropathogenicity and the neurological spectrum of disease.
Justyna Jachman-Kapułka +3 more
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Understanding Enterovirus D68-Induced Neurologic Disease: A Basic Science Review
Viruses, 2019 In 2014, the United States (US) experienced an unprecedented epidemic of enterovirus D68 (EV-D68)-induced respiratory disease that was temporally associated with the emergence of acute flaccid myelitis (AFM), a paralytic disease occurring predominantly ...
Alison M. Hixon +5 more
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Combined mutations in nonstructural protein 14, envelope, and membrane proteins mitigate the neuropathogenicity of SARS-CoV-2 Omicron BA.1 in K18-hACE2 mice [PDF]
mSphereWe previously reported that mutations outside the spike protein play a role in the attenuation of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.1 variant in human ACE2 transgenic mice (K18-hACE2).
Kotou Sangare +5 more
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Amino acid changes accumulated in the fusion protein allow neuropathogenic measles viruses to use a broad repertoire of host factors for cell fusion triggering [PDF]
Journal of VirologyMeasles virus (MeV), an enveloped RNA virus belonging to the genus Morbillivirus of the family Paramyxoviridae, is the causative agent of measles, an acute febrile illness with skin rash. MeV has two types of envelope glycoproteins: the hemagglutinin (H)
Yuichi Hirai +3 more
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Viruses, 2017 Enterovirus 71 (EV71) is a common etiological agent of hand, foot, and mouth disease and fatal neurological diseases in children. The neuropathogenicity of severe EV71 infection has been documented, but studies comparing mouse models of severe and mild ...
Pin Yu +7 more
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Genetic evidence for serum amyloid P component as a drug target in neurodegenerative disorders [PDF]
Open BiologyThe mechanisms responsible for neuronal death causing cognitive loss in Alzheimer's disease (AD) and many other dementias are not known. Serum amyloid P component (SAP) is a constitutive plasma protein, which is cytotoxic for cerebral neurones and also ...
A. Floriaan Schmidt +6 more
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Interactions between Tick-Borne Encephalitis Virus Nonstructural Protein 1 and Blood–Brain Barrier Tight Junction Proteins: Potential Clues to Strain-Specific Neuropathogenicity [PDF]
ACS OmegaJarinya Chaopreecha +6 more
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miR-142-5p Disrupts Neuronal Morphogenesis Underlying Porcine Hemagglutinating Encephalomyelitis Virus Infection by Targeting Ulk1 [PDF]
Frontiers in Cellular and Infection Microbiology, 2017 Porcine hemagglutinating encephalomyelitis virus (PHEV) invades the central nervous system (CNS) and causes neurodegenerative disease in suckling piglets, but the understanding of its neuropathogenicity for neurological dysfunction remains limited. Here,
Zi Li +11 more
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Molecular Biological and Pathological Studies on Neuropathogenic Avian Leukosis Viruses and the Molecular Clones [PDF]
, 2023 岩手大学博士（獣医学）原著論文 Nishiura, H., Kubota, I., Kondo, Y., Kachi, M., Hatai, H., Sasaki, J., Goryo, M. and Ochiai, K. Neuropathogenicity of newly isolated avian leukosis viruses from chickens with osteopetrosis and mesenchymal neoplasms Avian Pathology 49(5 ...
西浦, 颯, NISHIURA, Hayate
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