Results 1 to 10 of about 2,199 (172)

Mechanisms of Neuroinvasion and Neuropathogenesis by Pathologic Flaviviruses

open access: yesViruses, 2023
Flaviviruses are present on every continent and cause significant morbidity and mortality. In many instances, severe cases of infection with flaviviruses involve the invasion of and damage to the central nervous system (CNS). Currently, there are several
Alfred T Harding, Liset de Vries
exaly   +4 more sources

Circulating Plasma Exosomal Proteins of Either SHIV-Infected Rhesus Macaque or HIV-Infected Patient Indicates a Link to Neuropathogenesis [PDF]

open access: yesViruses, 2023
Despite the suppression of human immunodeficiency virus (HIV) replication by combined antiretroviral therapy (cART), 50–60% of HIV-infected patients suffer from HIV-associated neurocognitive disorders (HAND).
Chen-Zhong Li   +2 more
exaly   +4 more sources

Zika virus Neuropathogenesis—Research and Understanding

open access: yesPathogens
Zika virus (ZIKV), a mosquito-borne flavivirus, is prominently associated with microcephaly in babies born to infected mothers as well as Guillain-Barré Syndrome in adults.
Hengli Tang, Anna D Metzler
exaly   +4 more sources

Type VI Secretion System Accessory Protein TagAB-5 Promotes Burkholderia pseudomallei Pathogenicity in Human Microglia

open access: yesBiomedicines, 2023
Central nervous system (CNS) melioidosis caused by Burkholderia pseudomallei is being increasingly reported. Because of the high mortality associated with CNS melioidosis, understanding the underlying mechanism of B.
Sanisa Lohitthai   +9 more
doaj   +1 more source

Neuropathogenesis caused by Trypanosoma brucei, still an enigma to be unveiled

open access: yesMicrobial Cell, 2021
Trypanosoma brucei is one of the protozoa parasites that can enter the brain and cause injury associated with toxic effects of parasite-derived molecules or with immune responses against infection.
Katherine Figarella
doaj   +1 more source

Duck Tembusu virus induces incomplete autophagy via the ERK/mTOR and AMPK/mTOR signalling pathways to promote viral replication in neuronal cells

open access: yesVeterinary Research, 2023
Duck Tembusu virus (DTMUV) is a neurotropic virus in the genus Flavivirus that causes massive economic losses to the poultry industry in China and neighbouring countries.
Qing Wang   +6 more
doaj   +1 more source

Do SARS-CoV-2 Variants Differ in Their Neuropathogenicity?

open access: yesmBio, 2023
Neurological complications associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are a huge societal problem. Although the neuropathogenicity of SARS-CoV-2 is not yet fully understood, there is evidence that SARS-CoV-2 ...
Lisa Bauer, Debby van Riel
doaj   +1 more source

Characterization of HIV-1 Infection in Microglia-Containing Human Cerebral Organoids

open access: yesViruses, 2022
The achievement of an HIV cure is dependent on the eradication or permanent silencing of HIV-latent viral reservoirs, including the understudied central nervous system (CNS) reservoir. This requires a deep understanding of the molecular mechanisms of HIV’
Stephanie B. H. Gumbs   +9 more
doaj   +1 more source

Fatal Dengue Cases Reveal Brain Injury and Viral Replication in Brain-Resident Cells Associated with the Local Production of Pro-Inflammatory Mediators

open access: yesViruses, 2020
Dengue is an arboviral disease caused by dengue virus (DENV), which is transmitted to humans by Aedes aegypti mosquitoes. Infection by DENV most commonly results in a mild flu-like illness; however, the disease has been increasingly associated with ...
Natália Salomão   +9 more
doaj   +1 more source

Elimination of False Positives Generated Through PCR Re-amplification of Differential Display cDNA

open access: yesBioTechniques, 1998
Differential display (DD) is a powerful molecular tool that allows the identification and subsequent isolation of transcripts differentially expressed between biological samples, for example, between undifferentiated and differentiated cells, between ...
G. Miele   +4 more
doaj   +1 more source

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