Results 1 to 10 of about 8,002 (210)

Mechanisms of Neuroinvasion and Neuropathogenesis by Pathologic Flaviviruses

Viruses, 2023
Flaviviruses are present on every continent and cause significant morbidity and mortality. In many instances, severe cases of infection with flaviviruses involve the invasion of and damage to the central nervous system (CNS). Currently, there are several
Alfred Harding, Liset de Vries
exaly   +4 more sources

Zika Virus and Neuropathogenesis: The Unanswered Question of Which Strain Is More Prone to Causing Microcephaly and Other Neurological Defects [PDF]

Frontiers in Cellular Neuroscience, 2021
Despite being perceived to be a relatively innocuous pathogen during its circulation in Africa in the 20th century, consequent outbreaks in French Polynesia and Latin America revealed the Zika virus (ZIKV) to be capable of causing severe neurological ...
Nerea Irigoyen
exaly   +8 more sources

Zika Virus Neuropathogenesis—Research and Understanding

Pathogens
Zika virus (ZIKV), a mosquito-borne flavivirus, is prominently associated with microcephaly in babies born to infected mothers as well as Guillain-Barré Syndrome in adults.
Hengli Tang, Anna Metzler
exaly   +4 more sources

Circulating Plasma Exosomal Proteins of Either SHIV-Infected Rhesus Macaque or HIV-Infected Patient Indicates a Link to Neuropathogenesis

Viruses, 2023
Despite the suppression of human immunodeficiency virus (HIV) replication by combined antiretroviral therapy (cART), 50–60% of HIV-infected patients suffer from HIV-associated neurocognitive disorders (HAND).
Chenzhong Li, Hogyoung Kim, Jeffrey G Shaffer   +2 more
exaly   +3 more sources

The activation of complement C5a-C5aR1 axis in astrocytes facilitates the neuropathogenesis due to EV-A71 infection by upregulating CXCL1

Journal of Virology
Enterovirus A71 (EV-A71) is a common small RNA virus that is highly neuroinvasive. Emerging evidence indicates that the complement fragment C5a and its receptor C5aR1 are important drivers of neuroinflammation.
Shuaiyin Chen, Rongguang Zhang, Yuefei Jin   +2 more
exaly   +3 more sources

Neuropathogenesis-on-chips for neurodegenerative diseases

Nature Communications
Developing diagnostics and treatments for neurodegenerative diseases (NDs) is challenging due to multifactorial pathogenesis that progresses gradually. Advanced in vitro systems that recapitulate patient-like pathophysiology are emerging as alternatives ...
Sarnai Amartumur, Huong Nguyen, Thuy Huynh, Testaverde S. Kim, Ran-Sook Woo, Eungseok Oh, Kyeong Kyu Kim, Luke P. Lee, Chaejeong Heo   +8 more
doaj   +3 more sources

Characterization of HIV-1 Infection in Microglia-Containing Human Cerebral Organoids

Viruses, 2022
The achievement of an HIV cure is dependent on the eradication or permanent silencing of HIV-latent viral reservoirs, including the understudied central nervous system (CNS) reservoir. This requires a deep understanding of the molecular mechanisms of HIV’
Stephanie B. H. Gumbs, Amber Berdenis van Berlekom, Raphael Kübler, Pauline J. Schipper, Lavina Gharu, Marco P. Boks, Paul R. Ormel, Annemarie M. J. Wensing, Lot D. de Witte, Monique Nijhuis   +9 more
doaj   +1 more source

The neuropathogenesis of AIDS [PDF]

Nature Reviews Immunology, 2005
HIV-associated dementia (HAD) is an important complication of the central nervous system in patients who are infected with HIV-1. Although the incidence of HAD has markedly decreased since it has become possible to effectively control viral replication in the blood by administering highly active antiretroviral therapy, a less severe form of HAD ...
González-Scarano, Francisco, Martín-García, Julio   +1 more
openaire   +2 more sources

Type VI Secretion System Accessory Protein TagAB-5 Promotes Burkholderia pseudomallei Pathogenicity in Human Microglia

Biomedicines, 2023
Central nervous system (CNS) melioidosis caused by Burkholderia pseudomallei is being increasingly reported. Because of the high mortality associated with CNS melioidosis, understanding the underlying mechanism of B.
Sanisa Lohitthai, Amporn Rungruengkitkun, Niramol Jitprasutwit, Thida Kong-Ngoen, Taksaon Duangurai, Sarunporn Tandhavanant, Passanesh Sukphopetch, Narisara Chantratita, Nitaya Indrawattana, Pornpan Pumirat   +9 more
doaj   +1 more source

Neuropathogenesis caused by Trypanosoma brucei, still an enigma to be unveiled

Microbial Cell, 2021
Trypanosoma brucei is one of the protozoa parasites that can enter the brain and cause injury associated with toxic effects of parasite-derived molecules or with immune responses against infection.
Katherine Figarella
doaj   +1 more source