Results 1 to 10 of about 6,232 (129)

Porcine hemagglutinating encephalomyelitis virus VW572 (not Gent/PS412 and Labadie) uses the CD81 receptor and MVB-derived exosomal pathway for efficient entry and spread in neuronal cells [PDF]

Journal of Virology
Porcine hemagglutinating encephalomyelitis virus (PHEV) is considered a neurotropic coronavirus that invades the peripheral (PNS) and central (CNS) nervous system of the pig and causes acute encephalomyelitis, also known as “vomiting and wasting disease.”
W. Zaib, C. Kaviani, X. Kang, Y. Gao, F. Vanden Broucke, W. Van den Broeck, S. Coppens, S. Theuns, H. Nauwynck, K. Laval   +9 more
doaj   +2 more sources

Effects of a PPAR delta agonist in a tauopathy mouse model [PDF]

Alzheimers Dement
Abstract Background Elevated levels of ptau (phosphorylated tau) is directly correlated with neurodegeneration and neuropathogenesis in Alzheimer’s disease(AD). The presence of ApoE allele is a significant genetic risk factor for the progression of AD. PPAR‐δ, a nuclear receptor highly expressed in CNS neurons, regulates metabolic processes that helps ...
Raychaudhuri U, Tang C, Singh H, Seyedmohammadlou M, Park S, Rose M, Spada A.   +6 more
europepmc   +2 more sources

Zika Virus and Neuropathogenesis: The Unanswered Question of Which Strain Is More Prone to Causing Microcephaly and Other Neurological Defects

Frontiers in Cellular Neuroscience, 2021
Despite being perceived to be a relatively innocuous pathogen during its circulation in Africa in the 20th century, consequent outbreaks in French Polynesia and Latin America revealed the Zika virus (ZIKV) to be capable of causing severe neurological ...
Emily Louise King, Nerea Irigoyen
doaj   +3 more sources

Neuropathogenesis of Old World Alphaviruses: Considerations for the Development of Medical Countermeasures [PDF]

Viruses
Chikungunya virus (CHIKV) and other alphaviruses that primarily induce arthritogenic disease in humans, known as “Old World” alphaviruses, present an emerging public health concern as geographic ranges of mosquito vectors expand due to climate change ...
Alyssa M. Lantz, Victoria K. Baxter
doaj   +2 more sources

Placental Extracellular Vesicles Exhibit Reduced Neurogenic Potential Linked to Changes in Their miRNA Landscape Upon HCMV Infection. [PDF]

J Extracell Biol
ABSTRACT Extracellular vesicles (EVs) are key mediators of maternal–foetal communication, regulating placental function and foetal development through the transfer of bioactive molecules. Although placental EVs play a crucial role in placental function during pregnancy, their contribution to foetal development, notably foetal brain, remains poorly ...
Martin C, Martin H, Bergamelli M, Lobjois L, Franco L, Bordes E, Benchoua A, Balor S, Kantar D, Coyaud E, Martins F, Favereaux A, Malnou CE.   +12 more
europepmc   +2 more sources

Expression of Purinergic and Endothelial Activation Markers in Brain Tissue From Fatal Microcephaly Associated With ZIKV. [PDF]

Immun Inflamm Dis
ABSTRACT Background Zika virus (ZIKV) is a flavivirus that has gained global attention due to its association with congenital microcephaly and neuroinflammatory responses. Markers of endothelial activation and purinergic signaling have been identified in the context of ZIKV neuropathogenesis, although the underlying mechanisms remain poorly understood.
Sousa JR, Batista Ferro G, Vieira Teixeira L, Silva C, Lima L, Neto O, Azevedo R, Chiang JO, Casseb LMN, Filho AJM, Martins LC, Quaresma JAS, Vasconcelos PFDC.   +12 more
europepmc   +2 more sources

Zika Virus Neuropathogenesis—Research and Understanding

Pathogens
Zika virus (ZIKV), a mosquito-borne flavivirus, is prominently associated with microcephaly in babies born to infected mothers as well as Guillain-Barré Syndrome in adults.
Anna D. Metzler, Hengli Tang
doaj   +3 more sources

Letermovir shows antiviral and neuroprotective effects in differentiating neurons and cerebral organoids mimicking human developing brain [PDF]

Cellular and Molecular Life Sciences
Human cytomegalovirus (HCMV) is the leading viral cause of congenital defects. The triggers of viral neuropathogenesis during congenital infection (cCMV) are still unclear, and treatment options are limited.
Beatrice Mercorelli, Elisa Poli, Anna Pianezzola, Elisabetta Faggin, Ravit Arav-Boger, Giorgio Palù, Arianna Loregian, Marta Trevisan   +7 more
doaj   +2 more sources

The activation of complement C5a-C5aR1 axis in astrocytes facilitates the neuropathogenesis due to EV-A71 infection by upregulating CXCL1 [PDF]

Journal of Virology
Enterovirus A71 (EV-A71) is a common small RNA virus that is highly neuroinvasive. Emerging evidence indicates that the complement fragment C5a and its receptor C5aR1 are important drivers of neuroinflammation.
Peiyu Zhu, Wangquan Ji, Dong Li, Fang Wang, Tiantian Sun, Haiyan Yang, Shuaiyin Chen, Weiguo Zhang, Yuefei Jin, Guangcai Duan   +9 more
doaj   +2 more sources

Neural cells are susceptible to historic and recently emerged Oropouche virus strains. [PDF]

PLoS Pathogens
Oropouche fever is a re-emerging global viral threat caused by infection with Oropouche virus (OROV). While disease is generally self-limiting, historical and recent reports of neurologic involvement highlight the importance of understanding the ...
Kaleigh A Connors, Maris R Pedlow, Zachary D Frey, Marjorie Cornejo Pontelli, Sean P J Whelan, W Paul Duprex, Leonardo D'Aiuto, Zachary P Wills, Amy L Hartman   +8 more
doaj   +2 more sources