Results 21 to 30 of about 2,199 (172)

Methamphetamine induces transcriptional changes in cultured HIV-infected mature monocytes that may contribute to HIV neuropathogenesis

, 2022
HIV-associated neurocognitive impairment (HIV-NCI) persists in 15-40% of people with HIV (PWH) despite effective antiretroviral therapy. HIV-NCI significantly impacts quality of life, and there is currently no effective treatment for it.
Chilunda, Vanessa, Weiselberg, Jessica,, Martinez-Meza, Samuel,, Weiselberg, Jessica, Berman, Joan W., Chilunda, Vanessa,, Berman, Joan W.,, Cheney, Laura, Mhamilawa, Lwidiko E., Mhamilawa, Lwidiko E,, Martinez-Meza, Samuel, Mhamilawa, Lwidiko E, Cheney, Laura,   +12 more
core   +1 more source

The role of catecholamines in HIV neuropathogenesis [PDF]

Brain Research, 2019
The success of anti-retroviral therapy has improved the quality of life and lifespan of HIV + individuals, transforming HIV infection into a chronic condition. These improvements have come with a cost, as chronic HIV infection and long-term therapy have resulted in the emergence of a number of new pathologies.
R, Nolan, P J, Gaskill
openaire   +2 more sources

Two Consecutive Prolines in the Fusion Peptide of Murine β-Coronavirus Spike Protein Predominantly Determine Fusogenicity and May Be Essential but Not Sufficient to Cause Demyelination

Viruses, 2022
Combined in silico, in vitro, and in vivo comparative studies between isogenic-recombinant Mouse-Hepatitis-Virus-RSA59 and its proline deletion mutant, revealed a remarkable contribution of centrally located two consecutive prolines (PP) from Spike ...
Abass Alao Safiriyu, Manmeet Singh, Abhinoy Kishore, Vaishali Mulchandani, Dibyajyoti Maity, Amrutamaya Behera, Bidisha Sinha, Debnath Pal, Jayasri Das Sarma   +8 more
doaj   +1 more source

Return of the Neurotropic Enteroviruses: Co-Opting Cellular Pathways for Infection

Viruses, 2021
Enteroviruses are among the most common human infectious agents. While infections are often mild, the severe neuropathogenesis associated with recent outbreaks of emerging non-polio enteroviruses, such as EV-A71 and EV-D68, highlights their continuing ...
Christine E. Peters, Jan E. Carette
doaj   +1 more source

The neuropathogenesis of HIV-1 infection [PDF]

FEMS Immunology & Medical Microbiology, 1999
HIV encephalitis is the common pathologic correlate of HIV-dementia (HAD). HIV-infected brain mononuclear phagocytes (MP) (macrophages and microglia) are reservoirs for persistent viral infection. When activated, MP contribute to neuronal damage.
W E, Zink, J, Zheng, Y, Persidsky, L, Poluektova, H E, Gendelman   +4 more
openaire   +2 more sources

The Effects of Opioids on HIV Neuropathogenesis [PDF]

Frontiers in Immunology, 2019
HIV associated neurocognitive disorders (HAND) are a group of neurological deficits that affect approximately half of people living with HIV (PLWH) despite effective antiretroviral therapy (ART). There are currently no reliable molecular biomarkers or treatments for HAND.
Aniella Murphy, John Barbaro, Pablo Martínez-Aguado, Vanessa Chilunda, Matias Jaureguiberry-Bravo, Joan W. Berman, Joan W. Berman   +6 more
openaire   +3 more sources

The Neuropathic Itch Caused by Pseudorabies Virus

Pathogens, 2020
Pseudorabies virus (PRV) is an alphaherpesvirus related to varicella-zoster virus (VZV) and herpes simplex virus type 1 (HSV1). PRV is the causative agent of Aujeskzy’s disease in swine.
Kathlyn Laval, Lynn W. Enquist
doaj   +1 more source

Dopamine increases CD14+CD16+ monocyte migration and adhesion in the context of substance abuse and HIV neuropathogenesis. [PDF]

, 2015
Drug abuse is a major comorbidity of HIV infection and cognitive disorders are often more severe in the drug abusing HIV infected population. CD14+CD16+ monocytes, a mature subpopulation of peripheral blood monocytes, are key mediators of HIV ...
Jacqueline S Coley, Eliseo A. Eugenin (437917), Peter J Gaskill, Tina M. Calderon (437913), Joan W. Berman (437918), Peter J. Gaskill, Jacqueline S. Coley, Joan W. Berman, Jacqueline S. Coley (688856), Tina M Calderon, Eliseo A Eugenin, Tina M. Calderon, Peter J. Gaskill (437916), Joan W Berman, Eliseo A. Eugenin, Eugenin Eliseo A., Gaskill Peter J., Berman Joan W., Calderon Tina M., Coley Jacqueline S.   +19 more
core   +1 more source

Table_5_In vitro and in silico Models to Study Mosquito-Borne Flavivirus Neuropathogenesis, Prevention, and Treatment.DOCX

, 2019
Mosquito-borne flaviviruses can cause disease in the nervous system, resulting in a significant burden of morbidity and mortality. Disease models are necessary to understand neuropathogenesis and identify potential therapeutics and vaccines.
David Pamies (1750783), Carlos A. Pardo (6930536), Laura S. Muñoz (6930530), Dana Freeman (6930533), Lucio Gama (139021), Megan Chesnut (6038933), Georgina Harris (718243)   +6 more
core   +1 more source

SARS-CoV-2 Infects Primary Neurons from Human ACE2 Expressing Mice and Upregulates Genes Involved in the Inflammatory and Necroptotic Pathways

Pathogens, 2022
Transgenic mice expressing human angiotensin-converting enzyme 2 under the cytokeratin 18 promoter (K18-hACE2) have been extensively used to investigate the pathogenesis and tissue tropism of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2 ...
Hussin A. Rothan, Pratima Kumari, Shannon Stone, Janhavi P. Natekar, Komal Arora, Tabassum T. Auroni, Mukesh Kumar   +6 more
doaj   +1 more source