Results 41 to 50 of about 2,199 (172)
Global Gene Expression Analysis of the Brainstem in EV71- and CVA16-Infected Gerbils
Viruses, 2019 Enterovirus 71 (EV71) and coxsackievirus A16 (CVA16) are the two most important pathogens of hand, foot, and mouth disease (HFMD). However, the neuropathogenesis of EV71 and CVA16 has not been elucidated.
Yi-Sheng Sun +8 more
doaj +1 more source
Frontiers in Immunology, 2022 Thirty-eight million people worldwide are living with HIV, PWH, a major public health problem. Antiretroviral therapy (ART) revolutionized HIV treatment and significantly increased the lifespan of PWH.
Aniella J. Murphy +6 more
doaj +1 more source
Brain Pathology, Volume 36, Issue 6, November 2026.Brain viral reservoirs were undetectable in neonatal SIV during the first 3 days post infection; antiretroviral therapy (ART) at 3 dpi prevented brain reservoir seeding and normalized metabolic function, highlighting the necessity of very early treatment to protect the developing CNS.
Li Ma +12 more
wiley +1 more source
Apoptosis and HIV neuropathogenesis
Medical Hypotheses, 1995 A consequence of HIV infection may be neurological dysfunction secondary to the presence of virus in the central nervous system (CNS). The CNS tropism of HIV and the mechanisms that govern its dissemination are not well defined. One view is that HIV enters the brain through the diapedesis of infected monocytes from blood into the perivascular space ...
openaire +2 more sources
Murine coronavirus neuropathogenesis: determinants of virulence [PDF]
Journal of Neurovirology, 2010 Murine coronavirus, mouse hepatitis virus (MHV), causes various diseases depending on the strain and route of inoculation. Both the JHM and A59 strains, when inoculated intracranially or intranasally, are neurovirulent. Comparison of the highly virulent JHM isolate, JHM.SD, with less virulent JHM isolates and with A59 has been used to determine the ...
Cowley, Timothy J, Weiss, Susan R
openaire +2 more sources
ApoE lipidation state directs immunometabolic reprogramming of human microglia
Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.Abstract INTRODUCTION ApoE ε4 is the strongest genetic risk factor for Alzheimer's disease (AD). Emerging evidence suggests that ApoE4 increases AD risk by disrupting microglial metabolism and function. However, whether ApoE lipidation state contributes to microglial dysfunction remains poorly understood. METHODS Human microglia were treated with lipid‐
Tsion G. Shiferaw +14 more
wiley +1 more source
, 2019 Mosquito-borne flaviviruses can cause disease in the nervous system, resulting in a significant burden of morbidity and mortality. Disease models are necessary to understand neuropathogenesis and identify potential therapeutics and vaccines.
David Pamies (1750783) +6 more
core +1 more source
Spread of Oropouche Virus into the Central Nervous System in Mouse
Viruses, 2014 Oropouche virus (OROV) is an important cause of arboviral illness in Brazil and other Latin American countries, with most cases clinically manifested as acute febrile illness referred to as Oropouche fever, including myalgia, headache, arthralgia and ...
Rodrigo I. Santos +7 more
doaj +1 more source
Journal of Medical Virology, Volume 98, Issue 10, October 2026.ABSTRACT Pathophysiological mechanisms of neurological manifestations in COVID‐19 are not fully known yet. In this case‐control study, proteomic analysis was used to characterize cerebrospinal fluid (CSF) samples from COVID‐19 patients with acute neurological manifestations primarily categorized as: isolated refractory headache (n = 12), encephalopathy
Nicole Lardini Freitas +8 more
wiley +1 more source
Evaluating Human Immunodeficiency Virus (HIV) Neuropathogenesis on HIV -Associated Neurocognitive Disorder (HAND): Role of Virology, Cellular and Immunology Aspects [PDF]
Human Immunodeficiency Virus (HIV) became a worldwide pandemic with a global prevalence of 36.9 million in 2014. One of the neurological complications of HIV infection is HIV-associated neurocognitive disorder (HAND). The administration of antiretroviral
Purbasari, Bethasiwi
core +1 more source