Results 61 to 70 of about 7,477 (215)

Maresin-like 1 Ameliorates Neuropathology of Alzheimer’s Disease in Brains of a Transgenic Mouse Model

Biomedicines
(1) Background: Impeded resolution of inflammation contributes substantially to the pathogenesis of Alzheimer’s disease (AD); consequently, resolving inflammation is pivotal to the amelioration of AD pathology.
Pallavi Shrivastava, Yan Lu, Shanchun Su, Yuichi Kobayashi, Yuhai Zhao, Nathan Lien, Abdul-Razak Masoud, Walter J. Lukiw, Song Hong   +8 more
doaj   +1 more source

Hydrogen Sulfide Rescues Microglia From HIV Tat‐Driven Ferroptosis: Implications for HIV‐Associated Neuroinflammation

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
HIV Tat induces ferroptosis and proinflammatory activation in microglia through iron accumulation and oxidative stress. Hydrogen sulfide donor NaHS suppresses HIV Tat‐induced ferroptosis by restoring redox balance, reinforcing the SLC7A11‐GPX4 axis, and attenuating microglial inflammation, highlighting hydrogen sulfide as a potential therapeutic ...
Aitizaz Ul Ahsan, Frida L. Martínez‐Cuevas, Elias Horanieh, Seema Singh, Uma Maheswari Deshetty, Palsamy Periyasamy, Shilpa Buch   +6 more
wiley   +1 more source

Table_3_In vitro and in silico Models to Study Mosquito-Borne Flavivirus Neuropathogenesis, Prevention, and Treatment.DOCX

, 2019
Mosquito-borne flaviviruses can cause disease in the nervous system, resulting in a significant burden of morbidity and mortality. Disease models are necessary to understand neuropathogenesis and identify potential therapeutics and vaccines.
David Pamies (1750783), Carlos A. Pardo (6930536), Laura S. Muñoz (6930530), Dana Freeman (6930533), Lucio Gama (139021), Megan Chesnut (6038933), Georgina Harris (718243)   +6 more
core   +1 more source

A neuropatogenia do vírus da imunodeficiência humana Neuropathogenesis of HIV infection

Arquivos de Neuro-Psiquiatria, 1996
A disseminação da infecção pelo vírus da imunodeficiência humana (HIV) e o rápido evolver dos conhecimentos científicos a seu respeito, obrigam os médicos em geral - e os especialistas mais diretamente envolvidos com pacientes infectados - a se ...
Abelardo de Q-C Araújo, Alexandra Prufer Q-C Araújo, Sérgio A. Pereira Novis   +2 more
doaj   +1 more source

Table_4_In vitro and in silico Models to Study Mosquito-Borne Flavivirus Neuropathogenesis, Prevention, and Treatment.DOCX

, 2019
Mosquito-borne flaviviruses can cause disease in the nervous system, resulting in a significant burden of morbidity and mortality. Disease models are necessary to understand neuropathogenesis and identify potential therapeutics and vaccines.
David Pamies (1750783), Carlos A. Pardo (6930536), Laura S. Muñoz (6930530), Dana Freeman (6930533), Lucio Gama (139021), Megan Chesnut (6038933), Georgina Harris (718243)   +6 more
core   +1 more source

Organoids: From Bench to Bedside Applications

MedComm, Volume 7, Issue 6, June 2026.
Organoids, as a groundbreaking biomedical research platform, utilize adult stem cells (ASCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) as sources. By integrating specific growth and differentiation signals within an extracellular matrix (e.g., Matrigel), organoids guide cells to self‐assemble into three‐dimensional ...
Kelin Li, Rui Cao, Maochen Li, Zichao Tian, Huahao Fan, Bixia Hong, Xiaojuan Liu   +6 more
wiley   +1 more source

Table_1_In vitro and in silico Models to Study Mosquito-Borne Flavivirus Neuropathogenesis, Prevention, and Treatment.DOCX

, 2019
Mosquito-borne flaviviruses can cause disease in the nervous system, resulting in a significant burden of morbidity and mortality. Disease models are necessary to understand neuropathogenesis and identify potential therapeutics and vaccines.
David Pamies (1750783), Carlos A. Pardo (6930536), Laura S. Muñoz (6930530), Dana Freeman (6930533), Lucio Gama (139021), Megan Chesnut (6038933), Georgina Harris (718243)   +6 more
core   +1 more source

Nipah Virus Encephalitis: Pathogenetic Aspects and Current Therapeutic Strategies

Pathogens
Nipah virus (NiV) is a highly pathogenic zoonotic paramyxovirus responsible for sporadic outbreaks of severe disease with high case fatality rates in South and Southeast Asia.
Gaetano Scotto, Vincenzina Fazio, Ali Muhammed Moula, Sri Charan Bindu Bavisetty, Alessia Franza, Salvatore Massa   +5 more
doaj   +1 more source

Microglial reactivity and nodule formation are associated with Synaptodendritic damage in the brains of people with HIV‐1

Brain Pathology, Volume 36, Issue 3, May 2026.
Despite effective ART, neurocognitive impairment persists in people with HIV. Brains from PWH present exacerbated microgliosis and formation of microglial nodules that are actively engaged in neuronal phagocytosis, resulting in neuronal injury and dendritic loss.
Roberta S. Dos Reis, Lauren A. Ignatz, Sathish Selvam, Marc C. E. Wagner, Sara Gianella, Antoine Chaillon, Vanessa Gomez‐Moreno, Jeremy Martison, Leah H. Rubin, Sabina Heberlen, Valentina Stosor, Jordan Lake, Velpandi Ayyavoo   +12 more
wiley   +1 more source

RIPK3 and caspase 8 collaborate to limit herpes simplex encephalitis.

PLoS Pathogens, 2022
Invasion of the brain by herpes simplex virus 1 (HSV1) can lead to the development of herpes simplex encephalitis (HSE) that is often associated with significant morbidity and mortality regardless of therapeutic intervention.
Hongyan Guo, Heather S Koehler, Edward S Mocarski, Richard D Dix   +3 more
doaj   +1 more source