Results 71 to 80 of about 2,199 (172)

Tembusu virus neuroinvasion and neuropathogenesis: lessons from blood–brain barrier dysfunction in neurotropic flaviviruses

open access: yesFrontiers in Veterinary Science
Central nervous system (CNS) pathogenesis remains a critical but incompletely resolved aspect of flavivirus infection. Neurotropic flaviviruses usually initiate replication in peripheral tissues but can subsequently access the CNS, causing encephalitis ...
Zheng Ni   +14 more
doaj   +1 more source

In‐Vitro Evaluation of HIV/SARS‐CoV‐2 Co‐Infection Mediated Proteomic Changes in Astrocytes and Pericytes Reveals Altered Signaling Pathways Associated With Neurodegenerative Disorders

open access: yesJournal of Medical Virology, Volume 98, Issue 8, August 2026.
ABSTRACT Coronavirus disease 2019 (COVID‐19) survivors frequently experience a wide range of symptoms known as post‐acute sequelae of SARS‐CoV‐2 (PASC) or long COVID. Importantly, complications arising from microvascular dysfunction, blood‐brain barrier (BBB) disruption, and chronic neuroinflammation have been implicated in driving PASC within the ...
Arpan Acharya   +7 more
wiley   +1 more source

Nipah Virus: A Neurotropic Zoonosis—From Molecular Biology to Clinical Manifestations and Translational Advances

open access: yesViruses
Nipah virus (NiV) is a single-stranded negative-sense RNA virus of the genus Henipavirus, family Paramyxoviridae. The World Health Organization has declared NiV a priority pathogen with a great public health risk due to its epidemic potential and lack of
Vignesh Mariappan, Heinz Feldmann
doaj   +1 more source

RIPK3 and caspase 8 collaborate to limit herpes simplex encephalitis.

open access: yesPLoS Pathogens, 2022
Invasion of the brain by herpes simplex virus 1 (HSV1) can lead to the development of herpes simplex encephalitis (HSE) that is often associated with significant morbidity and mortality regardless of therapeutic intervention.
Hongyan Guo   +3 more
doaj   +1 more source

Japanese Encephalitis Virus and Host Innate Immunity: Insights Into TLR Signaling, PRR Crosstalk, and Viral Immune Evasion

open access: yesCell Biochemistry and Function, Volume 44, Issue 7, July 2026.
ABSTRACT Japanese encephalitis virus (JEV), a neurotropic flavivirus and a major cause of viral encephalitis, poses a significant global health threat due to its neuroinvasive potential. Host innate immune responses, particularly those mediated by pattern‐recognition receptors such as Toll‐like receptors (TLRs) and RIG‐I–like receptors, play critical ...
Mohammad Enamul Hoque Kayesh   +2 more
wiley   +1 more source

Prohibitin plays a critical role in Enterovirus 71 neuropathogenesis. [PDF]

open access: yes, 2018
A close relative of poliovirus, enterovirus 71 (EV71) is regarded as an important neurotropic virus of serious public health concern. EV71 causes Hand, Foot and Mouth Disease and has been associated with neurological complications in young children.
Sylvie Alonso   +9 more
core   +1 more source

EcoHIV Infection of Primary Murine Brain Cell Cultures to Model HIV Replication and Neuropathogenesis

open access: yesViruses
Background. EcoHIV is a chimeric HIV that replicates in mice in CD4+ T cells, macrophages, and microglia (but not in neurons), causing lasting neurocognitive impairment resembling neurocognitive disease in people living with HIV.
Boe-Hyun Kim   +5 more
doaj   +1 more source

Understanding Enterovirus D68-Induced Neurologic Disease: A Basic Science Review

open access: yesViruses, 2019
In 2014, the United States (US) experienced an unprecedented epidemic of enterovirus D68 (EV-D68)-induced respiratory disease that was temporally associated with the emergence of acute flaccid myelitis (AFM), a paralytic disease occurring predominantly ...
Alison M. Hixon   +5 more
doaj   +1 more source

Host neuronal PRSS3 interacts with enterovirus A71 3A protein and its role in viral replication

open access: yesScientific Reports, 2022
Enterovirus A71 (EV-A71) causes hand, foot, and mouth disease associated with neurological complications in young children. Currently, there is no specific treatment for EV-A71 infection due to the inadequate information on viral biology and ...
Patthaya Rattanakomol   +5 more
doaj   +1 more source

Chandipura Virus: An Emerging Neurological Threat Transmitted by Sandflies in India

open access: yesImmunity, Inflammation and Disease, Volume 14, Issue 7, July 2026.
Chandipura virus (CHPV), a neurotropic arbovirus transmitted primarily by sandflies, has emerged as a significant public health concern in India following recurrent outbreaks with high pediatric fatality rates. This review highlights the virus's virology, transmission dynamics, clinical features, and the urgent need for improved diagnostics ...
Abrar Ahmad Zargar   +2 more
wiley   +1 more source

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