Results 91 to 100 of about 7,477 (215)
, 2016 We previously showed that New Zealand White (NZWRs) and cottontail rabbits (CTRs) are a suitable model for studying immune mechanisms behind virus control and non-lethal neuropathogenesis associated with West Nile virus (WNV) and Murray Valley ...
Bowen, R.A. +11 more
core +1 more source
Medicine Bulletin, Volume 1, Issue 2, Page 200-212, December 2025.ABSTRACT Background and Aim Diabetes‐associated cognitive decline (DACD) is a prevalent central nervous system disorder that lacks effective therapies and remains poorly understood in terms of its underlying mechanisms. The activation of cGAS, a crucial cytosolic nucleic acid sensor for double‐stranded DNA, initiates the STING signaling pathway, which ...
Hai‐Jun Zhang +6 more
wiley +1 more source
The TH1/TH2 Response Imbalance Zika Virus Pathogenesis: An Immunological Paradox
APMIS, Volume 133, Issue 12, December 2025.ABSTRACT Since its identification in 1947 and its global emergence in the Americas decades later, the Zika virus (ZIKV) has proven to be a multifaceted challenge to public health. Among the many aspects that remain poorly understood, the complex immunological paradox between Th1 and Th2 responses stands out, playing a central role in the ...
Carla Menezes +6 more
wiley +1 more source
Glia, Volume 73, Issue 11, Page 2273-2288, November 2025.Main Points ER stress amplifies TNF‐α, OSM, and IL‐1β responses in astrocytes. PERK and JAK1 signaling are required for the synergistic interaction between ER stress and inflammatory cytokines. Translational suppression attenuates the synthesis of the negative feedback regulators IκBα and SOCS3.
Anirudhya Lahiri +8 more
wiley +1 more source
Down syndrome (DS), characterised by compromised brain development and intellectual challenges, often manifests Alzheimer's disease (AD) -like symptoms. Utilising the Web of Science Core Collection (WOSCC) database from January 1, 2000, to July 31, 2023,
Cheah, Pike-See +6 more
core +1 more source
Differences in Neuropathogenesis of Encephalitic California Serogroup Viruses
, 2019 The California serogroup of orthobunyaviruses comprises a group of mosquitoborne viruses, including La Crosse (LACV), snowshoe hare (SSHV), Tahyna (TAHV), Jamestown Canyon (JCV), and Inkoo (INKV) viruses, that cause neurologic disease in humans of ...
Clayton W. Winkler +2 more
core +1 more source
Synaptic Plasticity in the CA1 Area of the Hippocampus of Scrapie-Infected Mice
Neurobiology of Disease, 1998 Using conventionalin vitroextracellular field potential recordings we have investigated both short- and long-term synaptic plasticity in the hippocampal CA1 area of mice infected with ME7 scrapie.
Alex R. Johnston +3 more
doaj +1 more source
Neuropathogenesis in COVID-19 [PDF]
Journal of Neuropathology & Experimental Neurology, 2020 Altable, Marcos +1 more
openaire +2 more sources
Neuropathogenesis of Prion Disease
Future Neurology, 2014 ABSTRACT: Although much is known about prion diseases (characterized by a post-translational misfolding of the prion protein [PrP]) and their neuropathology and molecular pathology, the fundamental cause of illness, the basic neuropathogenesis, remains uncertain. There are three broad considerations discussed in this review: the possible loss of normal
Louise Davidson, Richard Knight
openaire +1 more source
Subcellular Mechanisms of Presenilin-Mediated Enhancement of Calcium Signaling
Neurobiology of Disease, 2001 Mutations in presenilin-1 (PS1), the leading cause of early-onset, autosomal-dominant familial Alzheimer's disease (FAD), enhance calcium signaling mediated by inositol 1,4,5-trisphosphate (IP3).
Malcolm A. Leissring +3 more
doaj +1 more source