Results 101 to 110 of about 2,199 (172)
Neuropathogenesis of Japanese Encephalitis in a Primate Model
PLoS Neglected Tropical Diseases, 2014 BACKGROUND Japanese encephalitis (JE) is a major cause of mortality and morbidity for which there is no treatment. In addition to direct viral cytopathology, the inflammatory response is postulated to contribute to the pathogenesis. Our goal was to determine the contribution of bystander effects and inflammatory mediators to neuronal cell death ...
Khin Saw Aye Myint +8 more
openaire +5 more sources
VirusesChikungunya virus (CHIKV) and other alphaviruses that primarily induce arthritogenic disease in humans, known as “Old World” alphaviruses, present an emerging public health concern as geographic ranges of mosquito vectors expand due to climate change ...
Alyssa M. Lantz, Victoria K. Baxter
doaj +1 more source
Subcellular Mechanisms of Presenilin-Mediated Enhancement of Calcium Signaling
Neurobiology of Disease, 2001 Mutations in presenilin-1 (PS1), the leading cause of early-onset, autosomal-dominant familial Alzheimer's disease (FAD), enhance calcium signaling mediated by inositol 1,4,5-trisphosphate (IP3).
Malcolm A. Leissring +3 more
doaj +1 more source
Neuropathogenesis-on-chips for neurodegenerative diseases
Nature CommunicationsAbstractDeveloping diagnostics and treatments for neurodegenerative diseases (NDs) is challenging due to multifactorial pathogenesis that progresses gradually. Advanced in vitro systems that recapitulate patient-like pathophysiology are emerging as alternatives to conventional animal-based models.
Sarnai Amartumur +8 more
openaire +3 more sources
The Role of GM-CSF in the Neuropathogenesis of Simian Immunodeficiency Virus (SIV)
, 2021 Why do neurocognitive disorders persist in people living with HIV while taking combination antiretroviral therapy (cART)? • The brain is a known reservoir for HIV. • HIV can act on myeloid cell populations like macrophages.
Delery, Elizabeth, Meckley, Rachael
core
mSphereSerotype 3 (T3) strains of mammalian orthoreovirus (reovirus) spread to the central nervous system to infect the brain and cause lethal encephalitis in newborn mice.
Kira A. Griswold +9 more
doaj +1 more source
, 2017 Feline Immunodeficiency virus (FIV), similar to its human analog human immunodeficiency virus (HIV), enters the central nervous system (CNS) soon after infection and establishes a protected viral reservoir.
Lola Hudson, Rick B. Meeker, Rick Meeker
core +1 more source
Analysis Of The Role For Antioxidant Enzyme Heme Oxygenase-1 In Brain Regional Hiv Neuropathogenesis And Blood-Brain Barrier Function [PDF]
, 2020 HIV-associated neurocognitive impairment (HIV NCI) persists in persons living with HIV (PLWH) despite the availability of suppressive combination antiretroviral therapy. Chronic inflammation, oxidative stress, and blood-brain barrier (BBB) disruption are
Gruenewald, Analise L
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IFNγ selectively induces astrocyte heme oxygenase-1 degradation: A novel proteasome role in HIV neuropathogenesis [PDF]
, 2015 HIV-associated neurocognitive disorders (HAND) affect 30% of infected patients despite suppressive antiretroviral therapy (ART) and are associated with chronic immune activation and oxidative stress within the systemic circulation and central nervous ...
Kovacsics, Colleen Elizabeth +1 more
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Neuropathogenesis of naturally occurring encephalitis caused by Listeria monocytogenes in ruminants
, 2010 Listeriosis is a serious food-borne disease with increasing frequency in humans and ruminants. Despite the facts that in both hosts, listeriosis can occur as rhombencephalitis and ruminants are a reservoir of Listeria monocytogenes (LM) strains ...
Zurbriggen, Andreas +18 more
core +1 more source