Results 81 to 90 of about 8,002 (210)

Hydrogen Sulfide Rescues Microglia From HIV Tat‐Driven Ferroptosis: Implications for HIV‐Associated Neuroinflammation

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
HIV Tat induces ferroptosis and proinflammatory activation in microglia through iron accumulation and oxidative stress. Hydrogen sulfide donor NaHS suppresses HIV Tat‐induced ferroptosis by restoring redox balance, reinforcing the SLC7A11‐GPX4 axis, and attenuating microglial inflammation, highlighting hydrogen sulfide as a potential therapeutic ...
Aitizaz Ul Ahsan, Frida L. Martínez‐Cuevas, Elias Horanieh, Seema Singh, Uma Maheswari Deshetty, Palsamy Periyasamy, Shilpa Buch   +6 more
wiley   +1 more source

Evaluating Human Immunodeficiency Virus (HIV) Neuropathogenesis on HIV -Associated Neurocognitive Disorder (HAND): Role of Virology, Cellular and Immunology Aspects [PDF]

Human Immunodeficiency Virus (HIV) became a worldwide pandemic with a global prevalence of 36.9 million in 2014. One of the neurological complications of HIV infection is HIV-associated neurocognitive disorder (HAND). The administration of antiretroviral
Purbasari, Bethasiwi
core   +1 more source

El virus de la inmunodeficiencia humana tipo 1 y el sistema nervioso central en desarrollo.

Biomédica: revista del Instituto Nacional de Salud, 2005
Actualmente, hay más de 42 millones de infectados con el virus de la inmunodeficiencia humana tipo 1 (VIH-1), de los cuales, 3,2 millones son niños y, de éstos, el 90% con transmisión vertical de la infección.
Jorge Alejandro Henao, Nora Vanegas, Oscar David Cano, Juan Carlos Hiromi, María Teresa Rugeles   +4 more
doaj   +1 more source

Dopamine increases CD14+CD16+ monocyte migration and adhesion in the context of substance abuse and HIV neuropathogenesis. [PDF]

, 2015
Drug abuse is a major comorbidity of HIV infection and cognitive disorders are often more severe in the drug abusing HIV infected population. CD14+CD16+ monocytes, a mature subpopulation of peripheral blood monocytes, are key mediators of HIV ...
Jacqueline S Coley, Eliseo A. Eugenin (437917), Peter J Gaskill, Tina M. Calderon (437913), Joan W. Berman (437918), Peter J. Gaskill, Jacqueline S. Coley, Joan W. Berman, Jacqueline S. Coley (688856), Tina M Calderon, Eliseo A Eugenin, Tina M. Calderon, Peter J. Gaskill (437916), Joan W Berman, Eliseo A. Eugenin   +14 more
core   +1 more source

Organoids: From Bench to Bedside Applications

MedComm, Volume 7, Issue 6, June 2026.
Organoids, as a groundbreaking biomedical research platform, utilize adult stem cells (ASCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) as sources. By integrating specific growth and differentiation signals within an extracellular matrix (e.g., Matrigel), organoids guide cells to self‐assemble into three‐dimensional ...
Kelin Li, Rui Cao, Maochen Li, Zichao Tian, Huahao Fan, Bixia Hong, Xiaojuan Liu   +6 more
wiley   +1 more source

RETRACTED ARTICLE: Pharmacological perturbation of CXCL1 signaling alleviates neuropathogenesis in a model of HEVA71 infection

Nature Communications, 2022
Neurological complications are frequently observed in severe Hand, Foot and Mouth Disease but the underlying causes are unknown. Here, the authors report infected astrocytes release CXCL1 which activates neuronal CXCR2 to cause neuropathogenesis.
Saravanan Gunaseelan, Mohammed Zacky Ariffin, Sanjay Khanna, Mong How Ooi, David Perera, Justin Jang Hann Chu, John Jia En Chua   +6 more
doaj   +1 more source

Role of T Lymphocytes in HIV Neuropathogenesis [PDF]

Current HIV/AIDS Reports, 2019
The purpose of this review is to summarize the current knowledge on the role of CD4+ T lymphocytes leading to HIV assault and persistence in the central nervous system (CNS) and the elimination of HIV-infected CNS resident cells by CD8+ T lymphocytes.HIV targets the CNS early in infection, and HIV-infected individuals suffer from mild forms of ...
Caroline, Subra, Lydie, Trautmann
openaire   +2 more sources

Microglial reactivity and nodule formation are associated with Synaptodendritic damage in the brains of people with HIV‐1

Brain Pathology, Volume 36, Issue 3, May 2026.
Despite effective ART, neurocognitive impairment persists in people with HIV. Brains from PWH present exacerbated microgliosis and formation of microglial nodules that are actively engaged in neuronal phagocytosis, resulting in neuronal injury and dendritic loss.
Roberta S. Dos Reis, Lauren A. Ignatz, Sathish Selvam, Marc C. E. Wagner, Sara Gianella, Antoine Chaillon, Vanessa Gomez‐Moreno, Jeremy Martison, Leah H. Rubin, Sabina Heberlen, Valentina Stosor, Jordan Lake, Velpandi Ayyavoo   +12 more
wiley   +1 more source

Throw out the Map: Neuropathogenesis of the Globally Expanding California Serogroup of Orthobunyaviruses

, 2019
The California serogroup (CSG) comprises 18 serologically and genetically related mosquito-borne orthobunyaviruses. Of these viruses, at least seven have been shown to cause neurological disease in humans, including the leading cause of pediatric ...
Alyssa B. Evans, Karin E. Peterson
core   +1 more source

Methamphetamine Dysregulates Macrophage Functions and Autophagy to Mediate HIV Neuropathogenesis

, 2022
HIV-neurocognitive impairment (HIV-NCI) can be a debilitating condition for people with HIV (PWH), despite the success of antiretroviral therapy (ART). Substance use disorder is often a comorbidity with HIV infection.
Simone Sidoli, Joan W. Berman, Barbaro, John M., Sidoli, Simone, Ana Maria Cuervo, Berman, Joan W., Cuervo, Ana Maria, John M. Barbaro   +7 more
core   +1 more source