Results 81 to 90 of about 7,477 (215)

Murine coronavirus neuropathogenesis: determinants of virulence [PDF]

Journal of Neurovirology, 2010
Murine coronavirus, mouse hepatitis virus (MHV), causes various diseases depending on the strain and route of inoculation. Both the JHM and A59 strains, when inoculated intracranially or intranasally, are neurovirulent. Comparison of the highly virulent JHM isolate, JHM.SD, with less virulent JHM isolates and with A59 has been used to determine the ...
Cowley, Timothy J, Weiss, Susan R
openaire   +2 more sources

Clinical Validation of α‐Synuclein in Salivary Extracellular Vesicles as a Biomarker for Parkinson's Disease: A Longitudinal Study

European Journal of Neurology, Volume 33, Issue 2, February 2026.
Salivary Extracellular vesicles (SEVs) isolated from PD patients exhibit increased levels of both total (α‐SynTot) and oligomeric alpha‐synuclein (α‐SynOlig). In PD patients, SEVS‐α‐SynOlig levels correlate with cognitive decline (MMSE) and motor fluctuations (MDS‐UPDRS IV) and remain stable after 1 year follow‐up.
Antonia Gurgone, Vita Cardinale, Marta M. Tangari, Serena Budicin, Debora Comai, Claudia Ledda, Leonardo Lopiano, Giovanni Camussi, Maurizio Zibetti, Maurizio Giustetto   +9 more
wiley   +1 more source

Prohibitin plays a critical role in Enterovirus 71 neuropathogenesis.

, 2018
A close relative of poliovirus, enterovirus 71 (EV71) is regarded as an important neurotropic virus of serious public health concern. EV71 causes Hand, Foot and Mouth Disease and has been associated with neurological complications in young children.
Sylvie Alonso, Justin Jang Hann Chu, Isabelle Bonne, Eng Lee Tan, Issac Horng Khit Too   +4 more
core   +1 more source

El virus de la inmunodeficiencia humana tipo 1 y el sistema nervioso central en desarrollo.

Biomédica: revista del Instituto Nacional de Salud, 2005
Actualmente, hay más de 42 millones de infectados con el virus de la inmunodeficiencia humana tipo 1 (VIH-1), de los cuales, 3,2 millones son niños y, de éstos, el 90% con transmisión vertical de la infección.
Jorge Alejandro Henao, Nora Vanegas, Oscar David Cano, Juan Carlos Hiromi, María Teresa Rugeles   +4 more
doaj   +1 more source

RETRACTED ARTICLE: Pharmacological perturbation of CXCL1 signaling alleviates neuropathogenesis in a model of HEVA71 infection

Nature Communications, 2022
Neurological complications are frequently observed in severe Hand, Foot and Mouth Disease but the underlying causes are unknown. Here, the authors report infected astrocytes release CXCL1 which activates neuronal CXCR2 to cause neuropathogenesis.
Saravanan Gunaseelan, Mohammed Zacky Ariffin, Sanjay Khanna, Mong How Ooi, David Perera, Justin Jang Hann Chu, John Jia En Chua   +6 more
doaj   +1 more source

Isolation and Transcriptomic Characterization of Genotype 5 Japanese Encephalitis Virus E138K Mutant Strain

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
The recent emergence of the genotype five Japanese encephalitis virus (G5 JEV) has once again drawn public attention to public health concerns. Plaque assay analysis of G5 JEV parental strain XZ0934 revealed two distinct plaque morphologies. To investigate this phenotypic heterogeneity, we performed single‐plaque purification and isolated two strains ...
Yuhong Yang, Ruichen Wang, Weijia Zhang, Qikai Yin, Fan Li, Shihong Fu, Kai Nie, Qianqian Cui, Songtao Xu, Huanyu Wang, Jianchao Wei   +10 more
wiley   +1 more source

Sleep duration promotes resistance and resilience to tau in older women at risk for Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.
Abstract INTRODUCTION Resistance and resilience are pathways through which modifiable behaviors may reduce Alzheimer's disease (AD) risk. Sleep – a known modifiable factor – is understudied in this context, especially among older women at elevated risk for AD.
Jordan Stiver, Xin Wang, Kitty K. Lui, Melanie A Dratva, Ella T. Lifset, Nadine C. Heyworth, Charlotte S. Rivera, Atul Malhotra, Michael L. Thomas, Erin E. Sundermann, Sarah J. Banks   +10 more
wiley   +1 more source

Throw out the Map: Neuropathogenesis of the Globally Expanding California Serogroup of Orthobunyaviruses

, 2019
The California serogroup (CSG) comprises 18 serologically and genetically related mosquito-borne orthobunyaviruses. Of these viruses, at least seven have been shown to cause neurological disease in humans, including the leading cause of pediatric ...
Alyssa B. Evans, Karin E. Peterson
core   +1 more source

Methamphetamine Dysregulates Macrophage Functions and Autophagy to Mediate HIV Neuropathogenesis

, 2022
HIV-neurocognitive impairment (HIV-NCI) can be a debilitating condition for people with HIV (PWH), despite the success of antiretroviral therapy (ART). Substance use disorder is often a comorbidity with HIV infection.
Simone Sidoli, Joan W. Berman, Barbaro, John M., Sidoli, Simone, Ana Maria Cuervo, Berman, Joan W., Cuervo, Ana Maria, John M. Barbaro   +7 more
core   +1 more source

Role of T Lymphocytes in HIV Neuropathogenesis [PDF]

Current HIV/AIDS Reports, 2019
The purpose of this review is to summarize the current knowledge on the role of CD4+ T lymphocytes leading to HIV assault and persistence in the central nervous system (CNS) and the elimination of HIV-infected CNS resident cells by CD8+ T lymphocytes.HIV targets the CNS early in infection, and HIV-infected individuals suffer from mild forms of ...
Caroline, Subra, Lydie, Trautmann
openaire   +2 more sources