Results 51 to 60 of about 8,002 (210)

Murine coronavirus neuropathogenesis: determinants of virulence [PDF]

Journal of Neurovirology, 2010
Murine coronavirus, mouse hepatitis virus (MHV), causes various diseases depending on the strain and route of inoculation. Both the JHM and A59 strains, when inoculated intracranially or intranasally, are neurovirulent. Comparison of the highly virulent JHM isolate, JHM.SD, with less virulent JHM isolates and with A59 has been used to determine the ...
Cowley, Timothy J, Weiss, Susan R
openaire   +2 more sources

Table_5_In vitro and in silico Models to Study Mosquito-Borne Flavivirus Neuropathogenesis, Prevention, and Treatment.DOCX

, 2019
Mosquito-borne flaviviruses can cause disease in the nervous system, resulting in a significant burden of morbidity and mortality. Disease models are necessary to understand neuropathogenesis and identify potential therapeutics and vaccines.
David Pamies (1750783), Carlos A. Pardo (6930536), Laura S. Muñoz (6930530), Dana Freeman (6930533), Lucio Gama (139021), Megan Chesnut (6038933), Georgina Harris (718243)   +6 more
core   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

Table_2_In vitro and in silico Models to Study Mosquito-Borne Flavivirus Neuropathogenesis, Prevention, and Treatment.DOCX

, 2019
Mosquito-borne flaviviruses can cause disease in the nervous system, resulting in a significant burden of morbidity and mortality. Disease models are necessary to understand neuropathogenesis and identify potential therapeutics and vaccines.
David Pamies (1750783), Carlos A. Pardo (6930536), Laura S. Muñoz (6930530), Dana Freeman (6930533), Lucio Gama (139021), Megan Chesnut (6038933), Georgina Harris (718243)   +6 more
core   +1 more source

Prohibitin plays a critical role in Enterovirus 71 neuropathogenesis. [PDF]

, 2018
A close relative of poliovirus, enterovirus 71 (EV71) is regarded as an important neurotropic virus of serious public health concern. EV71 causes Hand, Foot and Mouth Disease and has been associated with neurological complications in young children.
Sylvie Alonso, Justin Jang Hann Chu, Isabelle Bonne, Eng Lee Tan, Issac Horng Khit Too   +4 more
core   +1 more source

Methamphetamine induces transcriptional changes in cultured HIV-infected mature monocytes that may contribute to HIV neuropathogenesis

, 2022
HIV-associated neurocognitive impairment (HIV-NCI) persists in 15-40% of people with HIV (PWH) despite effective antiretroviral therapy. HIV-NCI significantly impacts quality of life, and there is currently no effective treatment for it.
Chilunda, Vanessa, Weiselberg, Jessica,, Martinez-Meza, Samuel,, Weiselberg, Jessica, Berman, Joan W., Chilunda, Vanessa,, Berman, Joan W.,, Cheney, Laura, Mhamilawa, Lwidiko E., Mhamilawa, Lwidiko E,, Martinez-Meza, Samuel, Mhamilawa, Lwidiko E, Cheney, Laura,   +12 more
core   +1 more source

Targeting Microglial HDAC3 Enhances Aβ Clearance and Neuroprotection in APP/PS1 Mice: A Ketogenic Diet‐Driven Strategy

Food Frontiers, Volume 7, Issue 5, September 2026.
Ketogenic diet (KD) confers neuroprotection in Alzheimer's disease by inhibiting microglial HDAC3. This simultaneously enhances Aβ clearance via TREM2‐mediated phagocytosis and AMPK–ULK1‐driven autophagy, while suppressing NLRP3 inflammasome activation, ultimately attenuating Aβ/tau pathology and neuronal damage. ABSTRACT Growing evidence suggests that
Mingxiao Zheng, Gabriele Loers, Shengnan Lin, Hans‐Christian Siebert, Qingpeng Wang, Ruiyan Zhang, Xuexing Zheng, Ning Zhang   +7 more
wiley   +1 more source

Murine Models of Central Nervous System Disease following Congenital Human Cytomegalovirus Infections

Pathogens, 2021
Human cytomegalovirus infection of the developing fetus is a leading cause of neurodevelopmental disorders in infants and children, leading to long-term neurological sequela in a significant number of infected children.
Jerome Moulden, Cathy Yea Won Sung, Ilija Brizic, Stipan Jonjic, William Britt   +4 more
doaj   +1 more source

SARS-CoV-2-Related Olfactory Dysfunction: Autopsy Findings, Histopathology, and Evaluation of Viral RNA and ACE2 Expression in Olfactory Bulbs

Biomedicines
Background: The COVID-19 pandemic has been a health emergency with a significant impact on the world due to its high infectiousness. The disease, primarily identified in the lower respiratory tract, develops with numerous clinical symptoms affecting ...
Marco Dell’Aquila, Concetta Cafiero, Alessandra Micera, Egidio Stigliano, Maria Pia Ottaiano, Giulio Benincasa, Beniamino Schiavone, Leo Guidobaldi, Luigi Santacroce, Salvatore Pisconti, Vincenzo Arena, Raffaele Palmirotta   +11 more
doaj   +1 more source

Neurological Manifestations of Dengue Infection

Frontiers in Cellular and Infection Microbiology, 2017
Dengue counts among the most commonly encountered arboviral diseases, representing the fastest spreading tropical illness in the world. It is prevalent in 128 countries, and each year >2.5 billion people are at risk of dengue virus infection worldwide.
Guo-Hong Li, Zhi-Jie Ning, Yi-Ming Liu, Xiao-Hong Li   +3 more
doaj   +1 more source