Results 51 to 60 of about 7,477 (215)

Methamphetamine induces transcriptional changes in cultured HIV-infected mature monocytes that may contribute to HIV neuropathogenesis

, 2022
HIV-associated neurocognitive impairment (HIV-NCI) persists in 15-40% of people with HIV (PWH) despite effective antiretroviral therapy. HIV-NCI significantly impacts quality of life, and there is currently no effective treatment for it.
Chilunda, Vanessa, Weiselberg, Jessica,, Martinez-Meza, Samuel,, Weiselberg, Jessica, Berman, Joan W., Chilunda, Vanessa,, Berman, Joan W.,, Cheney, Laura, Mhamilawa, Lwidiko E., Mhamilawa, Lwidiko E,, Martinez-Meza, Samuel, Mhamilawa, Lwidiko E, Cheney, Laura,   +12 more
core   +1 more source

Brain viral reservoir seeding and neurological metabolic dysregulation in early‐life immunodeficiency virus infection

Brain Pathology, EarlyView.
Brain viral reservoirs were undetectable in neonatal SIV during the first 3 days post infection; antiretroviral therapy (ART) at 3 dpi prevented brain reservoir seeding and normalized metabolic function, highlighting the necessity of very early treatment to protect the developing CNS.
Li Ma, Robert Blair, Yao‐Zhong Liu, Xiaolei Wang, Eunice Vincent, Christopher Yu, Lara A. Doyle‐Meyers, Cissy Zhang, Ahmad Saied, Anne Le, Ronald S. Veazey, Qigui Yu, Huanbin Xu   +12 more
wiley   +1 more source

Table_5_In vitro and in silico Models to Study Mosquito-Borne Flavivirus Neuropathogenesis, Prevention, and Treatment.DOCX

, 2019
Mosquito-borne flaviviruses can cause disease in the nervous system, resulting in a significant burden of morbidity and mortality. Disease models are necessary to understand neuropathogenesis and identify potential therapeutics and vaccines.
David Pamies (1750783), Carlos A. Pardo (6930536), Laura S. Muñoz (6930530), Dana Freeman (6930533), Lucio Gama (139021), Megan Chesnut (6038933), Georgina Harris (718243)   +6 more
core   +1 more source

Murine Models of Central Nervous System Disease following Congenital Human Cytomegalovirus Infections

Pathogens, 2021
Human cytomegalovirus infection of the developing fetus is a leading cause of neurodevelopmental disorders in infants and children, leading to long-term neurological sequela in a significant number of infected children.
Jerome Moulden, Cathy Yea Won Sung, Ilija Brizic, Stipan Jonjic, William Britt   +4 more
doaj   +1 more source

Single‐Nucleus Multiomic Analysis Reveals Immune–Metabolic Reprogramming Consistent With Maladaptive Trained Immunity in HIV‐Associated Neurocognitive Disorders

Glia, Volume 74, Issue 8, August 2026.
Single‐nucleus multiomic profiling of postmortem brain reveals coordinated immune, metabolic, and epigenomic reprogramming in glia of people with HIV consistent with maladaptive trained immunity sustaining neuroinflammation in HAND. ABSTRACT HIV‐associated neurocognitive disorders (HAND) remain prevalent in people with HIV (PWH) despite effective ...
Siera Martinez, Anelia Horvath, Luke Johnson, Tatiana Pushkarsky, Larisa Dubrovsky, Daria Starosyla, Ashley Bastin, Dmitri Sviridov, Michael Bukrinsky   +8 more
wiley   +1 more source

Table_2_In vitro and in silico Models to Study Mosquito-Borne Flavivirus Neuropathogenesis, Prevention, and Treatment.DOCX

, 2019
Mosquito-borne flaviviruses can cause disease in the nervous system, resulting in a significant burden of morbidity and mortality. Disease models are necessary to understand neuropathogenesis and identify potential therapeutics and vaccines.
David Pamies (1750783), Carlos A. Pardo (6930536), Laura S. Muñoz (6930530), Dana Freeman (6930533), Lucio Gama (139021), Megan Chesnut (6038933), Georgina Harris (718243)   +6 more
core   +1 more source

Zika Fetal Neuropathogenesis: Etiology of a Viral Syndrome. [PDF]

, 2016
The ongoing Zika virus epidemic in the Americas and the observed association with both fetal abnormalities (primary microcephaly) and adult autoimmune pathology (Guillain-Barré syndrome) has brought attention to this neglected pathogen.
Robert Malone, Khakhina, Svetlana, Malone, Robert, Jill Glasspool-Malone, Klase, Zachary A., Adriano De Bernardi Schneider, Svetlana Khakhina, Glasspool-Malone, Jill, Michael V Callahan, Schneider, Adriano De Bernardi, Callahan, Michael, Zachary A Klase   +11 more
core   +1 more source

Apoptosis and HIV neuropathogenesis

Medical Hypotheses, 1995
A consequence of HIV infection may be neurological dysfunction secondary to the presence of virus in the central nervous system (CNS). The CNS tropism of HIV and the mechanisms that govern its dissemination are not well defined. One view is that HIV enters the brain through the diapedesis of infected monocytes from blood into the perivascular space ...
openaire   +2 more sources

Neurological Manifestations of Dengue Infection

Frontiers in Cellular and Infection Microbiology, 2017
Dengue counts among the most commonly encountered arboviral diseases, representing the fastest spreading tropical illness in the world. It is prevalent in 128 countries, and each year >2.5 billion people are at risk of dengue virus infection worldwide.
Guo-Hong Li, Zhi-Jie Ning, Yi-Ming Liu, Xiao-Hong Li   +3 more
doaj   +1 more source

Evaluation of Withaferin A Content in Withania somnifera Using NMR and HPLC: A Comparative Assessment of Traditional and PCSL Extraction Methods

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
A comparative evaluation of traditional aqueous extractions and innovative pressurised cyclic solid–liquid extraction is presented for Withania somnifera leaves. Quantitative NMR, validated by HPLC, reveals a markedly enhanced preservation and recovery of withaferin A using PCSL.
Silvana Pedatella, Maria Chiara Di Meo, Daniele Naviglio, Gionata De Vico, Armando Zarrelli   +4 more
wiley   +1 more source