Results 51 to 60 of about 2,199 (172)

Zika Fetal Neuropathogenesis: Etiology of a Viral Syndrome. [PDF]

, 2016
The ongoing Zika virus epidemic in the Americas and the observed association with both fetal abnormalities (primary microcephaly) and adult autoimmune pathology (Guillain-Barré syndrome) has brought attention to this neglected pathogen.
Robert Malone, Khakhina, Svetlana, Malone, Robert, Jill Glasspool-Malone, Klase, Zachary A., Adriano De Bernardi Schneider, Svetlana Khakhina, Glasspool-Malone, Jill, Michael V Callahan, Schneider, Adriano De Bernardi, Callahan, Michael, Zachary A Klase   +11 more
core   +1 more source

Region-Specific Apoptosis-Related Gene Expression Is Uncoupled from Viral RNA Load in Canine Distemper Neuropathogenesis

Viruses
Canine distemper virus (CDV) is a highly contagious morbillivirus associated with severe neurological disease in dogs. Although apoptosis is recognized as an important mechanism in CDV-associated neurodegeneration, the relationship between regional viral
Bruno Benetti Junta Torres, Bernardo De Caro Martins, Luana de Sousa Ribeiro, Alessandra Silva Dias Campos, Marcos Bryan Heinemann, Graciela Kunrath Lima, Eliane Gonçalves de Melo   +6 more
doaj   +1 more source

RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection

Advanced Science, Volume 13, Issue 49, 3 September 2026.
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun, Weijing Yang, Hao Zhou, Shuai Li, Xin Jiang, Jianyang Gu, Wenyan Zhang   +6 more
wiley   +1 more source

Tissue-specific transcription profile of cytokine and chemokine genes associated with flavivirus control and non-lethal neuropathogenesis in rabbits

, 2016
We previously showed that New Zealand White (NZWRs) and cottontail rabbits (CTRs) are a suitable model for studying immune mechanisms behind virus control and non-lethal neuropathogenesis associated with West Nile virus (WNV) and Murray Valley ...
Bowen, R.A., Suen, Willy W., Uddin, Muhammad Jasim, Prow, Natalie A., Hall, R.A., Suen, W.W., Hall, Roy A., Prow, N.A., Bielefeldt-Ohmann, Helle, Bielefeldt-Ohmann, H., Uddin, M.J., Bowen, Richard A.   +11 more
core   +1 more source

From Hepatitis to Encephalitis: Neuroinvasion and Antiviral Development in Rift Valley Fever Virus Infection

Pathogens
Rift Valley fever virus (RVFV) is a mosquito-borne zoonotic pathogen that causes substantial livestock losses and a range of severe human illnesses, including hemorrhagic disease, hepatitis, retinitis, vision loss, and delayed encephalitis.
Sawrab Roy, Lei Shi, Shuhui Liu, Wenjun Ma   +3 more
doaj   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

Down’s syndrome, neuroinflammation, and Alzheimer neuropathogenesis [PDF]

, 2013
Down syndrome (DS) is the result of triplication of chromosome 21 (trisomy 21) and is the prevailing cause of mental retardation. In addition to the mental deficiencies and physical anomalies noted at birth, triplication of chromosome 21 gene products ...
Griffin, W. Sue T., Donna M Wilcock, W Sue T Griffin, Wilcock, Donna M.   +3 more
core   +2 more sources

Murine Models of Central Nervous System Disease following Congenital Human Cytomegalovirus Infections

Pathogens, 2021
Human cytomegalovirus infection of the developing fetus is a leading cause of neurodevelopmental disorders in infants and children, leading to long-term neurological sequela in a significant number of infected children.
Jerome Moulden, Cathy Yea Won Sung, Ilija Brizic, Stipan Jonjic, William Britt   +4 more
doaj   +1 more source

Targeting Microglial HDAC3 Enhances Aβ Clearance and Neuroprotection in APP/PS1 Mice: A Ketogenic Diet‐Driven Strategy

Food Frontiers, Volume 7, Issue 5, September 2026.
Ketogenic diet (KD) confers neuroprotection in Alzheimer's disease by inhibiting microglial HDAC3. This simultaneously enhances Aβ clearance via TREM2‐mediated phagocytosis and AMPK–ULK1‐driven autophagy, while suppressing NLRP3 inflammasome activation, ultimately attenuating Aβ/tau pathology and neuronal damage. ABSTRACT Growing evidence suggests that
Mingxiao Zheng, Gabriele Loers, Shengnan Lin, Hans‐Christian Siebert, Qingpeng Wang, Ruiyan Zhang, Xuexing Zheng, Ning Zhang   +7 more
wiley   +1 more source

Cocaine abuse and HIV-1 infection: Epidemiology and neuropathogenesis

, 1998
The epidemiology of cocaine abuse and potential relationships of cocaine withdrawal to human immunodeficiency virus type 1 (HIV-1)-associated dementia (HAD) are discussed.
Adarsh M Kumar, Keith A Crandall, Svetlana Reyblat, Clyde B McCoy, Kumar, Adarsh M, Bao Tong Zhang, Xin, Ke-Qin, Mahendra Kumar, McCoy, Clyde B, Lisa R Metsch, Reyblat, Svetlana, Crandall, Keith A, Metsch, Lisa R, Fujimura, Robert K, Kumar, Mahendra, Goodkin, Karl, Robert K Fujimura, Karl Goodkin, Virginia McCoy, Paul Shapshak, McCoy, Virginia, Zhang, Bao Tong, Ke-Qin Xin, Shapshak, Paul   +23 more
core   +1 more source