Results 31 to 40 of about 8,002 (210)

Viral Determinants of Virulence in Tick-Borne Flaviviruses

open access: yesViruses, 2018
Tick-borne flaviviruses have a global distribution and cause significant human disease, including encephalitis and hemorrhagic fever, and often result in neurologic sequelae.
Eliza M. Kellman   +3 more
doaj   +1 more source

Two Consecutive Prolines in the Fusion Peptide of Murine β-Coronavirus Spike Protein Predominantly Determine Fusogenicity and May Be Essential but Not Sufficient to Cause Demyelination

open access: yesViruses, 2022
Combined in silico, in vitro, and in vivo comparative studies between isogenic-recombinant Mouse-Hepatitis-Virus-RSA59 and its proline deletion mutant, revealed a remarkable contribution of centrally located two consecutive prolines (PP) from Spike ...
Abass Alao Safiriyu   +8 more
doaj   +1 more source

Feline Immunodeficiency Virus Neuropathogenesis: From Cats to Calcium [PDF]

open access: yes, 2007
Invasion of human immunodeficiency virus (HIV) into the central and peripheral nervous system produces a wide range of neurological symptoms, which continue to persist even with adequate therapeutic suppression of the systemic viremia. The development of
Meeker, Rick B., Rick B. Meeker
core   +1 more source

Return of the Neurotropic Enteroviruses: Co-Opting Cellular Pathways for Infection

open access: yesViruses, 2021
Enteroviruses are among the most common human infectious agents. While infections are often mild, the severe neuropathogenesis associated with recent outbreaks of emerging non-polio enteroviruses, such as EV-A71 and EV-D68, highlights their continuing ...
Christine E. Peters, Jan E. Carette
doaj   +1 more source

The role of catecholamines in HIV neuropathogenesis [PDF]

open access: yesBrain Research, 2019
The success of anti-retroviral therapy has improved the quality of life and lifespan of HIV + individuals, transforming HIV infection into a chronic condition. These improvements have come with a cost, as chronic HIV infection and long-term therapy have resulted in the emergence of a number of new pathologies.
R, Nolan, P J, Gaskill
openaire   +2 more sources

The neuropathogenesis of HIV-1 infection [PDF]

open access: yesFEMS Immunology & Medical Microbiology, 1999
HIV encephalitis is the common pathologic correlate of HIV-dementia (HAD). HIV-infected brain mononuclear phagocytes (MP) (macrophages and microglia) are reservoirs for persistent viral infection. When activated, MP contribute to neuronal damage.
W E, Zink   +4 more
openaire   +2 more sources

The Neuropathic Itch Caused by Pseudorabies Virus

open access: yesPathogens, 2020
Pseudorabies virus (PRV) is an alphaherpesvirus related to varicella-zoster virus (VZV) and herpes simplex virus type 1 (HSV1). PRV is the causative agent of Aujeskzy’s disease in swine.
Kathlyn Laval, Lynn W. Enquist
doaj   +1 more source

The Effects of Opioids on HIV Neuropathogenesis [PDF]

open access: yesFrontiers in Immunology, 2019
HIV associated neurocognitive disorders (HAND) are a group of neurological deficits that affect approximately half of people living with HIV (PLWH) despite effective antiretroviral therapy (ART). There are currently no reliable molecular biomarkers or treatments for HAND.
Aniella Murphy   +6 more
openaire   +3 more sources

SARS-CoV-2 Infects Primary Neurons from Human ACE2 Expressing Mice and Upregulates Genes Involved in the Inflammatory and Necroptotic Pathways

open access: yesPathogens, 2022
Transgenic mice expressing human angiotensin-converting enzyme 2 under the cytokeratin 18 promoter (K18-hACE2) have been extensively used to investigate the pathogenesis and tissue tropism of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2 ...
Hussin A. Rothan   +6 more
doaj   +1 more source

Morphological and Molecular Changes in the Cortex and Cerebellum of Immunocompetent Mice Infected with Zika Virus

open access: yesViruses, 2023
Zika virus (ZIKV) disease continues to be a threat to public health, and it is estimated that millions of people have been infected and that there have been more cases of serious complications than those already reported.
Aura Caterine Rengifo   +7 more
doaj   +1 more source

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