Results 31 to 40 of about 7,477 (215)

Henipavirus-induced neuropathogenesis in mice

Virology, 2023
Hendra virus (HeV) and Nipah virus (NiV) are henipaviruses that can cause fatal encephalitis in humans. Many animal models have been used to study henipavirus pathogenesis. In the mouse, HeV infection has previously shown that intranasal challenge can lead to neurological infection, however mice similarly challenged with NiV show no evidence of virus ...
Sarah J. Edwards, Brenton Rowe, Tristan Reid, Mary Tachedjian, Sarah Caruso, Kim Blasdell, Shumpei Watanabe, Jemma Bergfeld, Glenn A. Marsh   +8 more
openaire   +2 more sources

The Neuropathic Itch Caused by Pseudorabies Virus

Pathogens, 2020
Pseudorabies virus (PRV) is an alphaherpesvirus related to varicella-zoster virus (VZV) and herpes simplex virus type 1 (HSV1). PRV is the causative agent of Aujeskzy’s disease in swine.
Kathlyn Laval, Lynn W. Enquist
doaj   +1 more source

Distinct Virologic Properties of African and Epidemic Zika Virus Strains: The Role of the Envelope Protein in Viral Entry, Immune Activation, and Neuropathogenesis. [PDF]

Pathogens
The 2016 Zika virus (ZIKV) epidemic has largely subsided, but a key question remains. How did ZIKV evolve to become a virulent human pathogen compared to the virus of its original discovery?
Roozitalab A, Zhang C, Zhang J, Li G, Yang C, Hou W, Tang Q, Zhao RY.   +7 more
europepmc   +2 more sources

The neuropathogenesis of HIV-1 infection [PDF]

FEMS Immunology & Medical Microbiology, 1999
HIV encephalitis is the common pathologic correlate of HIV-dementia (HAD). HIV-infected brain mononuclear phagocytes (MP) (macrophages and microglia) are reservoirs for persistent viral infection. When activated, MP contribute to neuronal damage.
W E, Zink, J, Zheng, Y, Persidsky, L, Poluektova, H E, Gendelman   +4 more
openaire   +2 more sources

Highly efficient method for gene delivery in mouse dorsal root ganglia neurons

Frontiers in Molecular Neuroscience, 2015
The development of gene transfection technologies has greatly advanced our understanding of life sciences. While use of viral vectors has clear efficacy, it requires specific expertise and biological containment conditions.
Lingli eYu, Lingli eYu, Lingli eYu, Florie eReynaud, Julien eFalk, Ambre eSpencer, Ambre eSpencer, Ambre eSpencer, Yin-Di eDing, Yin-Di eDing, Yin-Di eDing, Véronique eBaumlé, Véronique eBaumlé, Ruisheng eLu, Ruisheng eLu, Valérie eCastellani, Chonggang eYuan, Chonggang eYuan, Brian B. Rudkin, Brian B. Rudkin   +19 more
doaj   +1 more source

The Effects of Opioids on HIV Neuropathogenesis [PDF]

Frontiers in Immunology, 2019
HIV associated neurocognitive disorders (HAND) are a group of neurological deficits that affect approximately half of people living with HIV (PLWH) despite effective antiretroviral therapy (ART). There are currently no reliable molecular biomarkers or treatments for HAND.
Aniella Murphy, John Barbaro, Pablo Martínez-Aguado, Vanessa Chilunda, Matias Jaureguiberry-Bravo, Joan W. Berman, Joan W. Berman   +6 more
openaire   +3 more sources

SARS-CoV-2 Infects Primary Neurons from Human ACE2 Expressing Mice and Upregulates Genes Involved in the Inflammatory and Necroptotic Pathways

Pathogens, 2022
Transgenic mice expressing human angiotensin-converting enzyme 2 under the cytokeratin 18 promoter (K18-hACE2) have been extensively used to investigate the pathogenesis and tissue tropism of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2 ...
Hussin A. Rothan, Pratima Kumari, Shannon Stone, Janhavi P. Natekar, Komal Arora, Tabassum T. Auroni, Mukesh Kumar   +6 more
doaj   +1 more source

Morphological and Molecular Changes in the Cortex and Cerebellum of Immunocompetent Mice Infected with Zika Virus

Viruses, 2023
Zika virus (ZIKV) disease continues to be a threat to public health, and it is estimated that millions of people have been infected and that there have been more cases of serious complications than those already reported.
Aura Caterine Rengifo, Jorge Rivera, Diego Alejandro Álvarez-Díaz, Julián Naizaque, Gerardo Santamaria, Sheryll Corchuelo, Claudia Yadira Gómez, Orlando Torres-Fernández   +7 more
doaj   +1 more source

Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis [PDF]

, 2009
Human African trypanosomiasis, or sleeping sickness, is caused by the protozoan parasites <i>Trypanosoma brucei rhodesiense</i> or <i>Trypanosoma brucei gambiense</i>, and is a major cause of systemic and neurological disability ...
Barrett, M.P., Stone, T.W., Bradley, B.M., Kennedy, P.G.E., Rodgers, J.   +4 more
core   +1 more source

Age-Dependent Invasion of Pseudorabies Virus into Porcine Central Nervous System via Maxillary Nerve

Pathogens, 2022
Pseudorabies virus (PRV) is the causative agent for Aujeszky’s disease, a disease that mainly affects pigs and incidentally other domestic and wild animals.
Konstantinos Papageorgiou, Ioannis Grivas, Maria Chiotelli, Alexandros Theodoridis, Emmanuel Panteris, Dimitris Papadopoulos, Evanthia Petridou, Nikolaos Papaioannou, Hans Nauwynck, Spyridon K. Kritas   +9 more
doaj   +1 more source