Mechanisms of Neuroinvasion and Neuropathogenesis by Pathologic Flaviviruses
Viruses, 2023 Flaviviruses are present on every continent and cause significant morbidity and mortality. In many instances, severe cases of infection with flaviviruses involve the invasion of and damage to the central nervous system (CNS). Currently, there are several
Alfred T Harding, Liset de Vries
exaly +8 more sources
V4020 Venezuelan Equine Encephalitis Vaccine: Mitigating Neuroinvasion and Reversion Through Rational Design [PDF]
VirusesThere is a need for safe and effective vaccines against the Venezuelan equine encephalitis virus that infects both humans and equines. However, development of a live-attenuated vaccine using the TC-83 strain has been hampered by substantial ...
Igor S Lukashevich +2 more
exaly +5 more sources
Changes in Sympathetic Activity in Prion Neuroinvasion
Neurobiology of Disease, 2010 Prion diseases are neurodegenerative diseases affecting humans and animals in which the infectious agent or prion is PrPres, a protease-resistant conformer of the cell protein PrP. The natural transmission route of prion diseases is peripheral infection,
Giuseppe Rossoni +2 more
exaly +6 more sources
A Journey to the Central Nervous System: Routes of Flaviviral Neuroinvasion in Human Disease [PDF]
Viruses, 2022 Many arboviruses, including viruses of the Flavivirus genus, are known to cause severe neurological disease in humans, often with long-lasting, debilitating sequalae in surviving patients. These emerging pathogens impact millions of people worldwide, yet
Eleanor M Marshall +2 more
exaly +4 more sources
Dysregulation of macrophage lipid metabolism underlies intracellular bacterial neuroinvasion [PDF]
Nature CommunicationsAcute central nervous system infection is highly lethal, yet the mechanisms by which intracellular bacteria infiltrate the brain remain unclear. Phagocytes are central to host defense, but how infected cells facilitate bacterial access to the brain is ...
Zhou Sha +22 more
doaj +3 more sources
The Forgotten Gate: Choroid Plexus and Blood-CSF Barrier in Arboviral Encephalitis [PDF]
LifeMechanisms of arboviral neuroinvasion are still incompletely resolved, despite longstanding emphasis on the blood-brain barrier (BBB) as the principal interface for central nervous system (CNS) entry.
Cecília M. Wodzik +6 more
doaj +2 more sources
Frontiers in Neuroanatomy, 2020 Evidence is mounting that the novel corona virus SARS-CoV2 inflicts neurological symptoms in a subgroup of COVID-19 patients. While plenty of theories on the route of neuroinvasion have been proposed, little histological evidence has been presented ...
Andreas F Mack +2 more
exaly +3 more sources
Bovine Spongiform Encephalopathy: An Integrated Review of Prion Mechanisms, Neuroanatomy, and Control [PDF]
Veterinary SciencesBovine spongiform encephalopathy (BSE) is a fatal transmissible spongiform encephalopathy caused by the misfolding of the host prion protein (PrP), representing a unique intersection between molecular pathology, neuroanatomy, and public health regulation.
Giovanna Pires Marzola +6 more
doaj +2 more sources
Neuroinvasion and Encephalitis Following Intranasal Inoculation of SARS-CoV-2 in K18-hACE2 Mice
Viruses, 2021 Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection can cause neurological disease in humans, but little is known about the pathogenesis of SARS-CoV-2 infection in the central nervous system (CNS).
Mukesh Kumar +2 more
exaly +3 more sources
Biological barriers underlying the extremely high fatality of symptomatic rabies: neuroinvasion, immune evasion, and blood–brain barrier restriction [PDF]
Frontiers in ImmunologyRabies remains one of the most preventable fatal infections, yet once clinical symptoms appear, survival is exceedingly rare. This paradox cannot be explained simply by the absence of a single effective antiviral drug.
Chen Sun +13 more
doaj +2 more sources