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Flavivirus: From Structure to Therapeutics Development

Life, 2021
Flaviviruses are still a hidden threat to global human safety, as we are reminded by recent reports of dengue virus infections in Singapore and African-lineage-like Zika virus infections in Brazil.
Rong Zhao, Xin Zhou
exaly   +4 more sources

Flavivirus-Mosquito Interactions [PDF]

Viruses, 2014
The Flavivirus genus is in the family Flaviviridae and is comprised of more than 70 viruses. These viruses have a broad geographic range, circulating on every continent except Antarctica.
Dana L Vanlandingham, Yan-Jang S Huang, Stephen Higgs   +2 more
exaly   +4 more sources

Implementación de un sistema de detección de flavivirus en mosquitos [PDF]

Memorias del Instituto de Investigaciones en Ciencias de la Salud, 2021
Los Flavivirus constituyen virus transmitidos por artrópodos, principalmente mosquitos. Pueden producir enfermedades en humanos y animales, también incluyen virus específicos de insectos que solo infectan y se replican en los insectos, no así en ...
Fátima Cardozo, Alejandra Rojas, Cynthia Bernal, Luis Ferreira, Adrián Díaz, Malvina Páez, Yvalena Guillén, Marta Contigiani, Laura Mendoza   +8 more
doaj   +2 more sources

Atlastin-2-mediated endoplasmic reticulum membrane tethering is critical for flavivirus replication. [PDF]

PLoS Biology
Flaviviruses (genus Orthoflavivirus) are arthropod-borne viruses which cause approximately 400 million annual global infections in humans. Flavivirus infection requires cellular machinery to facilitate replication and spread.
Jonathan Einterz Owen, Cheyanne Lynn Bemis, Qingyi Wang, Ambarish C Varadan, Jacob W Vander Velden, Laura Andačić, Olus Uyar, Mansi Gupta, Christopher D Scharer, Laurent Chatel-Chaix, Pietro Scaturro, Mehul S Suthar, Christopher J Neufeldt   +12 more
doaj   +2 more sources

Phenotypic and Genetic Variability of Isolates of ZIKV-2016 in Brazil

Microorganisms, 2022
The possibility of a Zika virus epidemic resurgence requires studies to understand its mechanisms of pathogenicity. Here, we describe the isolation of the Zika virus from breast milk (Rio-BM1) and compare its genetic and virological properties with two ...
Lidiane Menezes Souza Raphael, Iasmim Silva de Mello, Mariela Martínez Gómez, Ieda Pereira Ribeiro, Nathália Dias Furtado, Noemia Santana Lima, Alexandre Araújo Cunha Dos Santos, Déberli Ruiz Fernandes, Stephanie Oliveira Diaz da Cruz, Luana Santana Damasceno, Patrícia Brasil, Myrna Cristina Bonaldo   +11 more
doaj   +1 more source

Chikungunya Virus Shedding in Semen: A Case Series

Viruses, 2022
Background: Chikungunya is a viral disease that is transmitted by mosquitoes. It is characterized by an acute onset of fever and severe arthralgia. Methods: We describe six cases of acute and post-acute chikungunya in which viral RNA was detected in ...
Ezequias B. Martins, Fernanda de Bruycker-Nogueira, Cintia D. S. Rodrigues, Carolina C. Santos, Simone A. Sampaio, Allison A. Fabri, Vinícius Guerra-Campos, Maria Angélica M. Mares-Guia, Nieli R. C. Faria, Aline S. Santos, Marcelle A. S. Pinto, Michele F. B. Silva, Isabella C. V. Moraes, Anielle Pina-Costa, Ana Maria B. Filippis, Patrícia Brasil, Guilherme A. Calvet   +16 more
doaj   +1 more source

Co-Circulation of Two Independent Clades and Persistence of CHIKV-ECSA Genotype during Epidemic Waves in Rio de Janeiro, Southeast Brazil

Pathogens, 2020
The Chikungunya virus infection in Brazil has raised several concerns due to the rapid dissemination of the virus and its association with several clinical complications.
Allison Araújo Fabri, Cintia Damasceno dos Santos Rodrigues, Carolina Cardoso dos Santos, Flávia Löwen Levy Chalhoub, Simone Alves Sampaio, Nieli Rodrigues da Costa Faria, Maria Celeste Torres, Vagner Fonseca, Patricia Brasil, Guilherme Calvet, Luiz Carlos Junior Alcantara, Ana Maria Bispo de Filippis, Marta Giovanetti, Fernanda de Bruycker-Nogueira   +13 more
doaj   +1 more source

Flavivirus Concentrates Host ER in Main Replication Compartments to Facilitate Replication

Advanced Science, 2023
Flavivirus remodels the host endoplasmic reticulum (ER) to generate replication compartments (RCs) as the fundamental structures to accommodate viral replication.
Yali Ci, Kai Han, Jie Kong, Shuhan Huang, Yang Yang, Cheng‐Feng Qin, Lei Shi   +6 more
doaj   +1 more source

Guapiaçu virus, a new insect-specific flavivirus isolated from two species of Aedes mosquitoes from Brazil

Scientific Reports, 2021
Classical insect-flaviviruses (cISFVs) and dual host-related insect-specific flavivirus (dISFV) are within the major group of insect-specific flavivirus.
Geovani de Oliveira Ribeiro, Antonio Charlys da Costa, Danielle Elise Gill, Edcelha Soares D’Athaide Ribeiro, Marlisson Octavio da S. Rego, Fred Julio Costa Monteiro, Fabiola Villanova, Juliana Silva Nogueira, Adriana Yurika Maeda, Renato Pereira de Souza, Roozbeh Tahmasebi, Vanessa S. Morais, Ramendra Pati Pandey, V. Samuel Raj, Sirle Abdo Salloum Scandar, Fernanda Gisele da Silva Vasami, Leandro Guaraglia D’Agostino, Paulo César Maiorka, Xutao Deng, Maurício Lacerda Nogueira, Ester Cerdeira Sabino, Eric Delwart, Élcio Leal, Mariana Sequetin Cunha   +23 more
doaj   +1 more source

30 years of dengue fatal cases in Brazil: a laboratorial-based investigation of 1047 cases

BMC Infectious Diseases, 2018
Background Dengue viruses (DENV) have emerged and reemerged in Brazil in the past 30 years causing explosive epidemics. The disease may range from clinically asymptomatic infections to severe and fatal outcomes.
Priscila Conrado Guerra Nunes, Ana Maria Bispo de Filippis, Monique Queiroz da Rocha Lima, Nieli Rodrigues da Costa Faria, Fernanda de Bruycker-Nogueira, Jaqueline Bastos Santos, Manoela Heringer, Thaís Chouin-Carneiro, Dinair Couto-Lima, Bianca de Santis Gonçalves, Simone Alves Sampaio, Eliane Saraiva Machado de Araújo, Juan Camilo Sánchez-Arcila, Flávia Barreto dos Santos, Rita Maria Ribeiro Nogueira   +14 more
doaj   +1 more source