Results 21 to 30 of about 42,799 (212)

30 years of dengue fatal cases in Brazil: a laboratorial-based investigation of 1047 cases

BMC Infectious Diseases, 2018
Background Dengue viruses (DENV) have emerged and reemerged in Brazil in the past 30 years causing explosive epidemics. The disease may range from clinically asymptomatic infections to severe and fatal outcomes.
Priscila Conrado Guerra Nunes, Ana Maria Bispo de Filippis, Monique Queiroz da Rocha Lima, Nieli Rodrigues da Costa Faria, Fernanda de Bruycker-Nogueira, Jaqueline Bastos Santos, Manoela Heringer, Thaís Chouin-Carneiro, Dinair Couto-Lima, Bianca de Santis Gonçalves, Simone Alves Sampaio, Eliane Saraiva Machado de Araújo, Juan Camilo Sánchez-Arcila, Flávia Barreto dos Santos, Rita Maria Ribeiro Nogueira   +14 more
doaj   +1 more source

αVβ3 Integrin Expression Is Essential for Replication of Mosquito and Tick-Borne Flaviviruses in Murine Fibroblast Cells

Viruses, 2021
The Flavivirus genus includes a number of important viruses that are pathogenic to humans and animals and are responsible for outbreaks across the globe.
Vinicius Pinho dos Reis, Markus Keller, Katja Schmidt, Rainer Günter Ulrich, Martin Hermann Groschup   +4 more
doaj   +1 more source

Role of nonstructural protein NS2A in flavivirus assembly [PDF]

, 2008
Flavivirus nonstructural (NS) proteins are involved in RNA replication and modulation of the host antiviral response; however, evidence is mounting that some NS proteins also have essential roles in virus assembly.
Pijlman, G.P., Leung, J.Y., Khromykh, A.A., Hyde, J., Kondratieva, N., Mackenzie, J.M.   +5 more
core   +1 more source

Mechanism through which retrocyclin targets flavivirus multiplication [PDF]

, 2021
Currently, there are no approved drugs for the treatment of flavivirus infection. Accordingly, we tested the inhibitory effects of the novel θ-defensin retrocyclin-101 (RC-101) against flavivirus infection, and investigated the mechanism underlying the ...
Guo, Jiao, Sun, Lingling, Wang, Wei, Yuan, Weirong, Garzino-Demo, Alfredo, Liu, Yang, Lu, Wuyuan, Jia, Xiaoying, Xiao, Gengfu, Zhou, Minmin   +9 more
core   +1 more source

Sustainable, three-component, one-pot procedure to obtain active anti-flavivirus agents [PDF]

, 2021
The mosquito-borne viruses belonging to the genus Flavivirus such as Dengue virus (DENV) and Zika virus (ZIKV) cause human infections ranging from mild flu-like symptoms to hemorrhagic fevers, hepatitis, and neuropathies. To date, there are vaccines only
Violetta Cecchetti, Manfroni, G, Maria Sole Burali, Burali, MS, Kitti Wing Ki Chan, Gwee, CP, Vasudevan, SG, Chin Piaw Gwee, Oriana Tabarrini, Massari, S, Barreca, ML, Subhash G. Vasudevan, Stefano Sabatini, Maria Letizia Barreca, Tommaso Felicetti, Sylvie Alonso, Cecchetti, V, Alonso, S, Tabarrini, O, Ki Chan, KW, Giuseppe Manfroni, Felicetti, T, Serena Massari, Sabatini, S   +23 more
core   +1 more source

A glance at subgenomic flavivirus RNAs and microRNAs in flavivirus infections [PDF]

Virology Journal, 2016
The family Flaviviridae comprises a wide variety of viruses that are distributed worldwide, some of which are associated with high rates of morbidity and mortality. There are neither vaccines nor antivirals for most flavivirus infections, reinforcing the importance of research on different aspects of the viral life cycle.
Bavia, Lorena, Mosimann, Ana Luiza Pamplona, Aoki, Mateus Nóbrega, Duarte dos Santos, Claudia Nunes   +3 more
openaire   +2 more sources

Yellow fever outbreak, Imatong, southern Sudan. [PDF]

, 2004
In May 2003, the World Health Organization received reports about a possible outbreak of a hemorrhagic disease of unknown cause in the Imatong Mountains of southern Sudan.
Sang, Rosemary C, Victor O. Ofula, Onyango, Clayton O, Ofula, Victor O, Rodney L. Coldren, Robert Swanepoel, Coldren, Rodney L, Burt, Felicity J, Kevin M. De Cock, Rosemary C. Sang, Okoth, Fredrick A, Tukei, Peter M, Samson L. Konongoi, Abdourahmane Sow, Peter M. Tukei, De Cock, Kenin M, Waters, Norman C, Felicity J. Burt, Sow, Abourahmane, Norman C. Waters, Clayton O. Onyango, Fredrick A. Okoth, Konongoi, Sanson L, Clayton O. Onyango, Swanepoel, Robert   +24 more
core   +1 more source

Flavivirus Persistence in Wildlife Populations [PDF]

, 2021
A substantial number of humans are at risk for infection by vector-borne flaviviruses, resulting in considerable morbidity and mortality worldwide. These viruses also infect wildlife at a considerable rate, persistently cycling between ticks/mosquitoes ...
Maria Raisa Blahove, James Richard Carter   +1 more
core   +1 more source

Infection order outweighs the role of CD4+ T cells in tertiary flavivirus exposure

iScience, 2022
Summary: The link between CD4+ T and B cells during immune responses to DENV and ZIKV and their roles in cross-protection during heterologous infection is an active area of research.
Nicole Marzan-Rivera, Crisanta Serrano-Collazo, Lorna Cruz, Petraleigh Pantoja, Alexandra Ortiz-Rosa, Teresa Arana, Melween I. Martinez, Armando G. Burgos, Chiara Roman, Loyda B. Mendez, Elizabeth Geerling, Amelia K. Pinto, James D. Brien, Carlos A. Sariol   +13 more
doaj   +1 more source

Phylogeny of the Genus Flavivirus [PDF]

Journal of Virology, 1998
ABSTRACT We undertook a comprehensive phylogenetic study to establish the genetic relationship among the viruses of the genus Flavivirus and to compare the classification based on molecular phylogeny with the existing serologic method.
G, Kuno, G J, Chang, K R, Tsuchiya, N, Karabatsos, C B, Cropp   +4 more
openaire   +3 more sources