Results 41 to 50 of about 42,662 (220)

Role of nonstructural protein NS2A in flavivirus assembly

, 2008
Flavivirus nonstructural (NS) proteins are involved in RNA replication and modulation of the host antiviral response; however, evidence is mounting that some NS proteins also have essential roles in virus assembly.
Pijlman, G.P., Leung, J.Y., Khromykh, A.A., Hyde, J., Kondratieva, N., Mackenzie, J.M.   +5 more
core   +1 more source

The Multiples Fates of the Flavivirus RNA Genome During Pathogenesis [PDF]

, 2018
The Flavivirus genus comprises many viruses (including dengue, Zika, West Nile and yellow fever viruses) which constitute important public health concerns worldwide. For several of these pathogens, neither antivirals nor vaccines are currently available.
Clément Mazeaud, Mazeaud, Clément, Freppel, Wesley, Chatel-Chaix, Laurent, Wesley Freppel, Laurent Chatel-Chaix   +5 more
core   +1 more source

Zoonotic Flavivirus Exposure in Peri-Urban and Suburban Pig-Keeping in Hanoi, Vietnam, and the Knowledge and Preventive Practices of Pig Farmers

Tropical Medicine and Infectious Disease, 2022
Mosquito-borne diseases (MBDs), including those caused by flaviviruses, remain human health problems for developing and urbanizing economies. This cross-sectional study examined risks of flavivirus exposure through a survey regarding knowledge and ...
Long Pham-Thanh, Thang Nguyen-Tien, Ulf Magnusson, Vuong Nghia Bui, Anh Ngoc Bui, Åke Lundkvist, Duoc Trong Vu, Son Hai Tran, Minh Xuan Can, Hung Nguyen-Viet, Johanna F. Lindahl   +10 more
doaj   +1 more source

Sustainable, three-component, one-pot procedure to obtain active anti-flavivirus agents

, 2021
The mosquito-borne viruses belonging to the genus Flavivirus such as Dengue virus (DENV) and Zika virus (ZIKV) cause human infections ranging from mild flu-like symptoms to hemorrhagic fevers, hepatitis, and neuropathies. To date, there are vaccines only
Violetta Cecchetti, Manfroni, G, Maria Sole Burali, Burali, MS, Kitti Wing Ki Chan, Gwee, CP, Vasudevan, SG, Chin Piaw Gwee, Oriana Tabarrini, Massari, S, Barreca, ML, Subhash G. Vasudevan, Stefano Sabatini, Maria Letizia Barreca, Tommaso Felicetti, Sylvie Alonso, Cecchetti, V, Alonso, S, Tabarrini, O, Ki Chan, KW, Giuseppe Manfroni, Felicetti, T, Serena Massari, Sabatini, S   +23 more
core   +1 more source

Mouse Models of Heterologous Flavivirus Immunity: A Role for Cross-Reactive T Cells

Frontiers in Immunology, 2019
Most of the world is at risk of being infected with a flavivirus such as dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, tick-borne encephalitis virus, and Zika virus, significantly impacting millions of lives. Importantly,
Mariah Hassert, James D. Brien, Amelia K. Pinto   +2 more
doaj   +1 more source

Flaviviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines

Frontiers in Immunology, 2022
The innate immune system is the host’s first line of defense against the invasion of pathogens including flavivirus. The programmed cell death controlled by genes plays an irreplaceable role in resisting pathogen invasion and preventing pathogen ...
Yuhong Pan, Yuhong Pan, Yuhong Pan, Wenjun Cai, Wenjun Cai, Wenjun Cai, Anchun Cheng, Anchun Cheng, Anchun Cheng, Mingshu Wang, Mingshu Wang, Mingshu Wang, Zhongqiong Yin, Renyong Jia, Renyong Jia, Renyong Jia   +15 more
doaj   +1 more source

In a randomized trial, the live attenuated tetravalent dengue vaccine TV003 is well-tolerated and highly immunogenic in subjects with flavivirus exposure prior to vaccination. [PDF]

PLoS Neglected Tropical Diseases, 2017
Infection caused by the four serotypes of dengue virus (DENV-1-4) is a leading cause of mosquito-borne disease. Clinically-severe dengue disease is more common when secondary dengue infection occurs following prior infection with a heterologous dengue ...
Stephen S Whitehead, Anna P Durbin, Kristen K Pierce, Dan Elwood, Benjamin D McElvany, Ellen A Fraser, Marya P Carmolli, Cecilia M Tibery, Noreen A Hynes, Matthew Jo, Janece M Lovchik, Catherine J Larsson, Elena A Doty, Dorothy M Dickson, Catherine J Luke, Kanta Subbarao, Sean A Diehl, Beth D Kirkpatrick   +17 more
doaj   +1 more source

First detection of the Africa/Caribbean/Latin American subtype of Culex flavivirus in Asian country, Taiwan

, 2014
Culex flavivirus (CxFV), a member of the genus flavivirus, is a novel insectinsect-specific flavivirusesthat can be divided into two subtypes, the cytopathic Asia/U.S. and the noncytopathicAfrica/Caribbean/Latin American subtypes.
Yi-Chin Fan, Shyan-Song Chiou, Jen-Wei Lin, Gwong-Jen J. Chang, Wu-Chun Tu, Yi-Ying Chen   +5 more
core   +1 more source

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source

Detection of novel insect flavivirus sequences integrated in Aedes albopictus (Diptera: Culicidae) in Northern Italy

Virology Journal, 2009
The presence of DNA sequences integrated from a new flavivirus related to Cell Fusing Agent and Kamiti River Virus was identified in wild Aedes albopictus mosquito populations from the provinces of Trentino and Padova, Northern Italy.
Tenorio Antonio, Seco Mari, Vázquez Ana, Roiz David, Rizzoli Annapaola   +4 more
doaj   +1 more source