Results 61 to 70 of about 42,662 (220)
Advanced Science, EarlyView.By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang +13 more
wiley +1 more source
Usutski virus: novi Flavivirus u Hrvatskoj [Usutu virus: a novel flavivirus in Croatia] [PDF]
, 2015 Usutu virus (USUV) belongs to the family Flaviviridae, genus Flavivirus, Japanese encephalitis serocomplex. The virus was discovered in 1959 in South Africa and has emerged since 1996 causing epizootics with high avian mortality in Europe. The importance
Mlinarić-Galinović, Gordana +3 more
core
Rational design of West Nile virus vaccine through large replacement of 3′ UTR with internal poly(A)
EMBO Molecular Medicine, 2021 The genus Flavivirus comprises numerous emerging and re‐emerging arboviruses causing human illness. Vaccines are the best approach to prevent flavivirus diseases.
Ya‐Nan Zhang +15 more
doaj +1 more source
Advanced Science, EarlyView.Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang +17 more
wiley +1 more source
Pathogenesis of flavivirus encephalitis
, 2003 Within the flavivirus family, viruses that cause natural infections of the central nervous system (CNS) principally include members of the Japanese encephalitis virus (JEV) serogroup and the tick-borne encephalitis virus (TBEV) serocomplex. The pathogenesis of diseases involves complex interactions of viruses, which differ in neurovirulence potential ...
Chambers, Thomas J, Diamond, Michael S
openaire +2 more sources
TRIMming Flavivirus Infection [PDF]
Cell Host & Microbe, 2011 Tripartite motif (TRIM) proteins are novel players in antiviral innate immunity. In this issue of Cell Host & Microbe,Taylor et al. (2011) discover the mechanism of action of TRIM79α and show that this interferon-induced protein restricts tick-borne flaviviruses by targeting the viral polymerase for degradation.
openaire +2 more sources
Impact of PAF1 KO on flavivirus host dependency factors.
, 2021 (A) GSEA was performed using list of flavivirus host dependency genes. (B) Leading edge of flavivirus host dependency factors from GSEA. Heatmap represents log2 fold change relative to parental A549 following poly(I:C) treatment. (TIF)
Matthew W. Kenaston (11731556) +5 more
core +1 more source
Development of Double Antibody Sandwich ELISA for Detection of Duck or Goose Flavivirus
Journal of Integrative Agriculture, 2013 In order to establish double antibody sandwich enzyme-linked immunosorbent assay (DAS-ELISA) for detection of duck or goose flavivirus, polyclonal antibody against the flavivirus strain JS804 in geese and monoclonal antibody against the E protein of ...
Hui-min NIU +10 more
doaj +1 more source
Advanced Science, EarlyView.RNA structural profiling of Turnip Yellow Mosaic Virus by DMS‐MaPseq and DREEM analyses uncover that viral genome‐wide RSS is highly complicated and heterogeneous, with alternative RSSs widely distributed across the genome. Notably, the viral 3’ tRNA‐like structure adopts alternative conformations in vivo.
Jiaying Zhu +7 more
wiley +1 more source
Impact of flavivirus vaccine-induced immunity on primary Zika virus antibody response in humans.
PLoS Neglected Tropical Diseases, 2020 BackgroundZika virus has recently spread to South- and Central America, causing congenital birth defects and neurological complications. Many people at risk are flavivirus pre-immune due to prior infections with other flaviviruses (e.g.
Stefan Malafa +14 more
doaj +1 more source