Results 71 to 80 of about 60,828 (259)

The Zika outbreak of the 21st century. [PDF]

open access: yes, 2016
The Zika virus outbreak has captivated the attention of the global audience and information has spread rapidly and wildly through the internet and other media channels.
Ansari, Aftab   +3 more
core   +1 more source

ProTides for Antiviral Activity Beyond Liver Cells

open access: yesChemistry – A European Journal, EarlyView.
A strategy for obtaining prodrugs of antiviral nucleotides with broad tissue activity is presented that relies on cycloalkyl or cycloalkylalkyl esters, improving uptake and esterase cleavage, and producing nanomolar inhibitors in kidney, colon, and lung cells.
Felix Goebel   +5 more
wiley   +1 more source

A 212-nt long RNA structure in the Tobacco necrosis virus-D RNA genome is resistant to Xrn degradation [PDF]

open access: yes, 2019
Plus-strand RNA viruses can accumulate viral RNA degradation products during infections. Some of these decay intermediates are generated by the cytosolic 5′-to-3′ exoribonuclease Xrn1 (mammals and yeast) or Xrn4 (plants) and are formed when the enzyme ...
Chaminda, Gunawardene D.   +2 more
core   +1 more source

Does a decision support tool designed to depict West Nile virus risk explain variation in ruffed grouse Bonasa umbellus use of managed forests?

open access: yesWildlife Biology, EarlyView.
Infectious diseases are commonly cited as significant contributors to wildlife population declines. It is, therefore, important to investigate the extent to which tools designed to mitigate the effects of infectious diseases explain wildlife responses to habitat management.
Jacob Goldman   +8 more
wiley   +1 more source

Development of Double Antibody Sandwich ELISA for Detection of Duck or Goose Flavivirus

open access: yesJournal of Integrative Agriculture, 2013
In order to establish double antibody sandwich enzyme-linked immunosorbent assay (DAS-ELISA) for detection of duck or goose flavivirus, polyclonal antibody against the flavivirus strain JS804 in geese and monoclonal antibody against the E protein of ...
Hui-min NIU   +10 more
doaj   +1 more source

Rational design of West Nile virus vaccine through large replacement of 3′ UTR with internal poly(A)

open access: yesEMBO Molecular Medicine, 2021
The genus Flavivirus comprises numerous emerging and re‐emerging arboviruses causing human illness. Vaccines are the best approach to prevent flavivirus diseases.
Ya‐Nan Zhang   +15 more
doaj   +1 more source

RIPK3 restricts viral pathogenesis via cell death-independent neuroinflammation [PDF]

open access: yes, 2017
Receptor-interacting protein kinase-3 (RIPK3) is an activator of necroptotic cell death, but recent work has implicated additional roles for RIPK3 in inflammatory signaling independent of cell death.
Daniels, Brian P.   +9 more
core   +1 more source

Tick‐Borne Encephalitis (TBE) Vaccine in the National Immunisation Programme—For Whom, When and Where?

open access: yesActa Paediatrica, EarlyView.
ABSTRACT The incidence of Tick‐borne encephalitis (TBE) cases has increased. The presumed location of transmission of Tick‐borne encephalitis virus (TBEV) has been expanding increasingly in the western parts of Europe during the past decade. There has also been an increased incidence of surveillance‐reported TBE cases in southern Sweden and southern ...
H. H. Askling, D. Zavadska
wiley   +1 more source

Impact of flavivirus vaccine-induced immunity on primary Zika virus antibody response in humans.

open access: yesPLoS Neglected Tropical Diseases, 2020
BackgroundZika virus has recently spread to South- and Central America, causing congenital birth defects and neurological complications. Many people at risk are flavivirus pre-immune due to prior infections with other flaviviruses (e.g.
Stefan Malafa   +14 more
doaj   +1 more source

Autoimmune neurological conditions associated with Zika virus infection [PDF]

open access: yes, 2018
Zika virus (ZIKV) is an emerging flavivirus rapidly spreading throughout the tropical Americas. mosquitoes is the principal way of transmission of the virus to humans. ZIKV can be spread by transplacental, perinatal, and body fluids.
Acosta-Ampudia, Yeny   +8 more
core   +2 more sources

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