Results 11 to 20 of about 6,060 (200)

Old World Alphaviruses Use Distinct Mechanisms to Infect Brain Microvascular Endothelial Cells for Neuroinvasion [PDF]

Cell Reports
Several alphaviruses bypass the blood-brain barrier (BBB), causing debilitating or fatal encephalitis. Sindbis virus (SINV) has been extensively studied in vivo to understand alphavirus neuropathogenesis, yet the molecular details of neuroinvasion remain
Melody M H Li, Prashant Kaushal, Maria Villalba Nieto   +2 more
exaly   +3 more sources

Prions: from neurografts to neuroinvasion.

, 2000
Spongiform encephalopathies are infectious neurodegenerative diseases caused by pathogens that seem to be devoid of any informational nucleic acids. Histopathologically, these diseases are characterized by spongiform degeneration of the central nervous ...
Glatzel, M, Klein, M A, Brandner, S, Aguzzi, A; https://orcid.org/   +3 more
core   +7 more sources

Tembusu virus neuroinvasion and neuropathogenesis: lessons from blood–brain barrier dysfunction in neurotropic flaviviruses [PDF]

Frontiers in Veterinary Science
Central nervous system (CNS) pathogenesis remains a critical but incompletely resolved aspect of flavivirus infection. Neurotropic flaviviruses usually initiate replication in peripheral tissues but can subsequently access the CNS, causing encephalitis ...
Zheng Ni, Zicheng Zhang, Zicheng Zhang, Ting Zhou, Yinchu Zhu, Suxin Huo, Jionggang Hua, Xuejun Wu, Tao Yun, Liu Chen, Weicheng Ye, Yuan Fu, Zhuanli Wu, Guijun Wang, Zhuangli Bi   +14 more
doaj   +2 more sources

Tissue-Specific miRNA Responses to Tick-Borne Encephalitis Virus Strains in Mice [PDF]

Non-Coding RNA
Background/Objectives: Tick-borne encephalitis virus (TBEV) is a vector-borne flavivirus that targets the CNS and causes severe encephalitis with long-term neurological sequelae. As the geographic range of its vectors expands and climate conditions shift,
Elena V. Mikheeva, Galina S. Chicherina, Kseniya S. Aulova, Georgy A. Nevinsky, Anna M. Timofeeva   +4 more
doaj   +2 more sources

Molecular mechanisms of neuroinvasion by monocytes-macrophages in HIV-1 infection [PDF]

Retrovirology, 2010
HIV associated neurocognitive disorders and their histopathological correlates largely depend on the continuous seeding of the central nervous system with immune activated leukocytes, mainly monocytes/macrophages from the periphery.
Kaul Marcus, Gras Gabriel
doaj   +2 more sources

Current Understanding of West Nile Virus Clinical Manifestations, Immune Responses, Neuroinvasion, and Immunotherapeutic Implications

Pathogens, 2019
West Nile virus (WNV) is the most common mosquito-borne virus in North America. WNV-associated neuroinvasive disease affects all ages, although elderly and immunocompromised individuals are particularly at risk.
Fengwei Bai, Parminder J S Víg, A Arturo Leis   +2 more
exaly   +3 more sources

Targeting monocytic Occludin impairs transendothelial migration and HIV neuroinvasion

EMBO Reports
Transmigration of circulating monocytes from the bloodstream to tissues represents an early hallmark of inflammation. This process plays a pivotal role during viral neuroinvasion, encephalitis, and HIV-associated neurocognitive disorders.
Diana Brychka, Nilda Vanesa Ayala-Nunez, Amandine Dupas, Yonis Bare, Emma Partiot, Vincent Mittelheisser, Vincent Lucansky, Jacky G Goetz, Naël Osmani, Raphael Gaudin   +9 more
doaj   +2 more sources

Direct prion neuroinvasion following inhalation into the nasal cavity

mSphere
Inhalation of prions into the nasal cavity is an efficient route of infection. Following inhalation of infectious prions, animals develop disease with a similar incubation period compared with per os exposure, but with greater efficiency. To identify the
Anthony E. Kincaid, Melissa D. Clouse, Shawn M. Magrum, Jason C. Bartz   +3 more
doaj   +2 more sources

Antiviral Cytokine Response in Neuroinvasive and Non-Neuroinvasive West Nile Virus Infection [PDF]

Viruses, 2021
Data on the immune response to West Nile virus (WNV) are limited. We analyzed the antiviral cytokine response in serum and cerebrospinal fluid (CSF) samples of patients with WNV fever and WNV neuroinvasive disease using a multiplex bead-based assay for the simultaneous quantification of 13 human cytokines.
Snjezana Zidovec-Lepej, Tatjana Vilibic-Cavlek, Ljubo Barbic, Maja Ilic, Vladimir Savic, Irena Tabain, Thomas Ferenc, Ivana Grgic, Lana Gorenec, Maja Bogdanic, Vladimir Stevanovic, Dario Sabadi, Ljiljana Peric, Tanja Potocnik-Hunjadi, Elizabeta Dvorski, Tamara Butigan, Krunoslav Capak, Eddy Listes, Giovanni Savini   +18 more
openaire   +5 more sources

SARS-CoV-2 infection of the central nervous system in a 14-month-old child: A case report of a complete autopsy

The Lancet Regional Health. Americas, 2021
Background: Neurological and other systemic complications occur in adults with severe COVID-19. Here we describe SARS-CoV-2 infection complicated by neuroinvasion in the post-mortem tissues of a child.
Ismael Gomes, Karina Karmirian, Júlia T. Oliveira, Carolina da S.G. Pedrosa, Mayara Abud Mendes, Fernando Colonna Rosman, Leila Chimelli, Stevens Rehen   +7 more
doaj   +1 more source