Results 31 to 40 of about 6,060 (200)

Targeted Mutations in the Fusion Peptide Region of La Crosse Virus Attenuate Neuroinvasion and Confer Protection against Encephalitis

open access: yesViruses, 2022
La Crosse virus (LACV) is a major cause of pediatric encephalitis and aseptic meningitis in the Midwestern, Mid-Atlantic, and Southern United States, where it is an emerging pathogen.
Bradley S. Hollidge   +9 more
doaj   +1 more source

Skin-derived dendritic cells acquire and degrade the scrapie agent following in vitro exposure [PDF]

open access: yes, 2005
The accumulation of the scrapie agent in lymphoid tissues following inoculation via the skin is critical for efficient neuroinvasion, but how the agent is initially transported from the skin to the draining lymph node is not known. Langerhans cells (LCs)
Hopkins, John   +5 more
core   +1 more source

Revisiting the Immune Balance Theory: A Neurological Insight Into the Epidemic of COVID-19 and Its Alike

open access: yesFrontiers in Neurology, 2020
As the pandemic of COVID-19 is raging around the world, the mysteriousness of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) coronavirus is being revealed by the concerted endeavors of scientists.
Junjiao Wu   +3 more
doaj   +1 more source

A Route for Prion Neuroinvasion [PDF]

open access: yesNeuron, 2001
The astonishing recognition that self-propagating changes in protein structure may be at the basis of spongiform encephalopathies is changing our views of transmissible diseases. Infectious agents consisting of abnormally folded proteins (i.e., the prion) can propagate in host organisms using previously unrecognized routes and invade the brain after a ...
openaire   +2 more sources

CONCERNING THE NEUROTROPY AND NEUROINVASIVENESS OF CORONAVIRUSES

open access: yesJournal of Clinical Practice, 2020
At the present state of COVID-19 we may propose some preliminary thoughts on its direct and distant sequels. In our review we propose that novel virus SARS-CoV-2, as well as other members of Coronaviridae family, may possess neurotropic and neuroinvasive features; it may enter the nervous system via the intranasal way and directly infect human brain ...
Vladislav Voitenkov, E. V. Ekusheva
openaire   +2 more sources

Spatial Mapping of Genes Implicated in SARS-CoV-2 Neuroinvasion to Dorsolateral Prefrontal Cortex Gray Matter

open access: yesCOVID, 2023
Introduction: SARS-CoV-2 is the newest beta coronavirus family member to demonstrate neuroinvasive capability in severe cases of infection. Despite much research activity in the SARS-CoV-2/COVID-19 space, the gene-level biology of this phenomenon remains
Sai Batchu   +6 more
doaj   +1 more source

Multiple Neuroinvasive Pathways in COVID-19 [PDF]

open access: yesMolecular Neurobiology, 2020
COVID-19 is a highly infectious viral disease caused by the novel coronavirus SARS-CoV-2. While it was initially regarded as a strictly respiratory illness, the impact of COVID-19 on multiple organs is increasingly recognized. The brain is among the targets of COVID-19, and it can be impacted in multiple ways, both directly and indirectly. Direct brain
Bougakov, Dmitri   +2 more
openaire   +2 more sources

Hendra and Nipah Virus Infection in Cultured Human Olfactory Epithelial Cells

open access: yesmSphere, 2017
Henipaviruses are emerging zoonotic viruses and causative agents of encephalitis in humans. However, the mechanisms of entry into the central nervous system (CNS) in humans are not known.
Viktoriya Borisevich   +3 more
doaj   +1 more source

The Role of the Gastrointestinal System in Neuroinvasion by SARS-CoV-2

open access: yesFrontiers in Neuroscience, 2021
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is one of the most devastating pandemics in history.
Jiali Xu   +6 more
doaj   +1 more source

Neuroinvasion by Human Respiratory Coronaviruses

open access: yesJournal of Virology, 2000
ABSTRACTHuman coronaviruses (HCoV) cause common colds but can also infect neural cell cultures. To provide definitive experimental evidence for the neurotropism and neuroinvasion of HCoV and its possible association with multiple sclerosis (MS), we have performed an extensive search and characterization of HCoV RNA in a large panel of human brain ...
N, Arbour   +3 more
openaire   +3 more sources

Home - About - Disclaimer - Privacy