Results 11 to 20 of about 7,477 (215)

In vitro and in silico Models to Study Mosquito-Borne Flavivirus Neuropathogenesis, Prevention, and Treatment

Frontiers in Cellular and Infection Microbiology, 2019
Mosquito-borne flaviviruses can cause disease in the nervous system, resulting in a significant burden of morbidity and mortality. Disease models are necessary to understand neuropathogenesis and identify potential therapeutics and vaccines.
Megan Chesnut, Laura S. Muñoz, Laura S. Muñoz, Georgina Harris, Dana Freeman, Lucio Gama, Lucio Gama, Carlos A. Pardo, Carlos A. Pardo, David Pamies, David Pamies   +10 more
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Mechanisms of Neuroinvasion and Neuropathogenesis by Pathologic Flaviviruses

Viruses, 2023
Flaviviruses are present on every continent and cause significant morbidity and mortality. In many instances, severe cases of infection with flaviviruses involve the invasion of and damage to the central nervous system (CNS). Currently, there are several
Liset de Vries, Alfred T. Harding
doaj   +2 more sources

The neuropathogenesis of HIV-1 infection

Journal of Leukocyte Biology, 1994
HIV infection in brain revolves around productive viral replication in cells of mononuclear phagocyte lineage, including brain macrophages, microglia, and multinucleated giant cells [1–4].
Stuart A Lipton, Marc Tardieu, Howard E Gendelman, Hans S L M Nottet, Michael I Bukrinsky   +4 more
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Role of EphrinA3 in HIV-1 Neuropathogenesis

ASN Neuro, 2021
Glial cells perform important supporting functions for neurons through a dynamic crosstalk. Neuron–glia communication is the major phenomenon to sustain homeostatic functioning of the brain. Several interactive pathways between neurons and astrocytes are
Chitra Mohinder Singh Singal, Paritosh Jaiswal, Anuradha Mehta, Kanza Saleem, Pankaj Seth   +4 more
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Circulating Plasma Exosomal Proteins of Either SHIV-Infected Rhesus Macaque or HIV-Infected Patient Indicates a Link to Neuropathogenesis

Viruses, 2023
Despite the suppression of human immunodeficiency virus (HIV) replication by combined antiretroviral therapy (cART), 50–60% of HIV-infected patients suffer from HIV-associated neurocognitive disorders (HAND).
Partha K. Chandra, Stephen E. Braun, Sudipa Maity, Jorge A. Castorena-Gonzalez, Hogyoung Kim, Jeffrey G. Shaffer, Sinisa Cikic, Ibolya Rutkai, Jia Fan, Jessie J. Guidry, David K. Worthylake, Chenzhong Li, Asim B. Abdel-Mageed, David W. Busija   +13 more
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Neuropathogenesis-on-chips for neurodegenerative diseases

Nature Communications
Developing diagnostics and treatments for neurodegenerative diseases (NDs) is challenging due to multifactorial pathogenesis that progresses gradually. Advanced in vitro systems that recapitulate patient-like pathophysiology are emerging as alternatives ...
Sarnai Amartumur, Huong Nguyen, Thuy Huynh, Testaverde S. Kim, Ran-Sook Woo, Eungseok Oh, Kyeong Kyu Kim, Luke P. Lee, Chaejeong Heo   +8 more
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Type VI Secretion System Accessory Protein TagAB-5 Promotes Burkholderia pseudomallei Pathogenicity in Human Microglia

Biomedicines, 2023
Central nervous system (CNS) melioidosis caused by Burkholderia pseudomallei is being increasingly reported. Because of the high mortality associated with CNS melioidosis, understanding the underlying mechanism of B.
Sanisa Lohitthai, Amporn Rungruengkitkun, Niramol Jitprasutwit, Thida Kong-Ngoen, Taksaon Duangurai, Sarunporn Tandhavanant, Passanesh Sukphopetch, Narisara Chantratita, Nitaya Indrawattana, Pornpan Pumirat   +9 more
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Neuropathogenesis caused by Trypanosoma brucei, still an enigma to be unveiled

Microbial Cell, 2021
Trypanosoma brucei is one of the protozoa parasites that can enter the brain and cause injury associated with toxic effects of parasite-derived molecules or with immune responses against infection.
Katherine Figarella
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Duck Tembusu virus induces incomplete autophagy via the ERK/mTOR and AMPK/mTOR signalling pathways to promote viral replication in neuronal cells

Veterinary Research, 2023
Duck Tembusu virus (DTMUV) is a neurotropic virus in the genus Flavivirus that causes massive economic losses to the poultry industry in China and neighbouring countries.
Qing Wang, Yaqian Jiang, Guangbin Bao, Weiping Yao, Qing Yang, Shuyue Chen, Guijun Wang   +6 more
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Do SARS-CoV-2 Variants Differ in Their Neuropathogenicity?

mBio, 2023
Neurological complications associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are a huge societal problem. Although the neuropathogenicity of SARS-CoV-2 is not yet fully understood, there is evidence that SARS-CoV-2 ...
Lisa Bauer, Debby van Riel
doaj   +1 more source