Results 31 to 40 of about 1,091 (176)

Langat Virus Biology and Infection. [PDF]

Rev Med Virol
ABSTRACT Flaviviruses pose a major threat to global health and can cause severe disease in animals and humans. Among them, tick‐borne encephalitis virus (TBEV) and related members of the tick‐borne encephalitis (TBE) serocomplex are transmitted primarily by ticks and can lead to neurological disease, including encephalitis and death. Despite many years
Klestova Z, Sauter D, Schindler M, Iftner T.   +3 more
europepmc   +2 more sources

Microglia and astrocyte responses to neuropathogenic protozoan parasites [PDF]

Faculty Reviews, 2021
Cerebral toxoplasmosis and cerebral malaria are two important neurological diseases caused by protozoan parasites. In this review, we discuss recent findings regarding the innate immune responses of microglia and astrocytes to Toxoplasma and Plasmodium infection. In both infections, these tissue-resident glial cells perform a sentinel function mediated
Nasuhidehnavi, Azadeh, Yap, George S
openaire   +2 more sources

Visna Virus dUTPase Is Dispensable for Neuropathogenicity [PDF]

Journal of Virology, 1998
ABSTRACT The major part of the dUTPase-encoding region of the visna virus genome was deleted. Intracerebral injection of the mutant virus resulted in a somewhat reduced viral load compared to that resulting from injection of the wild type, especially in the lungs, but the neuropathogenic effects were comparable.
Petursson, G, Turelli, P, Matthiasdottir, S, Georgsson, G, Andresson, OS, Torsteinsdottir, S, Vigne, R, Andresdottir, V, Gunnarsson, E, Agnarsdottir, G, Querat, G   +10 more
openaire   +2 more sources

Neuropathogenic human coronaviruses: A review

Reviews in Medical Virology, 2020
SummaryHuman Coronaviruses (HCoVs) have long been known as respiratory viruses. However, there are reports of neurological findings in HCoV infections, particularly in patients infected with the novel severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) amid Coronavirus disease 2019 (COVID‐19) pandemic.
Abdelaziz, Osama S., Waffa, Zuraiha
openaire   +3 more sources

T cell deficiency precipitates antibody evasion and emergence of neurovirulent polyomavirus

eLife, 2022
JC polyomavirus (JCPyV) causes progressive multifocal leukoencephalopathy (PML), a life-threatening brain disease in immunocompromised patients. Inherited and acquired T cell deficiencies are associated with PML.
Matthew D Lauver, Ge Jin, Katelyn N Ayers, Sarah N Carey, Charles S Specht, Catherine S Abendroth, Aron E Lukacher   +6 more
doaj   +1 more source

Measles Fusion Machinery Is Dysregulated in Neuropathogenic Variants [PDF]

mBio, 2015
ABSTRACT Paramyxoviruses, including the human pathogen measles virus (MV), enter host cells by fusing their viral envelope with the target cell membrane. This fusion process is driven by the concerted actions of the two viral envelope glycoproteins, the receptor binding protein (hemagglutinin [H]) and the fusion (F) protein.
Jurgens, Eric M, Mathieu, Cyrille, Palermo, Laura M, Hardie, Diana, Horvat, Branka, Moscona, Anne, Porotto, Matteo   +6 more
openaire   +4 more sources

Collective fusion activity determines neurotropism of an en bloc transmitted enveloped virus. [PDF]

Sci Adv, 2023
麻疹（はしか）ウイルスが「協力」して脳炎を引き起こす仕組みを解明 --新規治療薬の開発やウイルス共通の進化メカニズム解明に期待--. 京都大学プレスリリース. 2023-01-30.Measles virus (MeV), which is usually non-neurotropic, sometimes persists in the brain and causes subacute sclerosing panencephalitis (SSPE) several years after ...
Shirogane Y, Harada H, Hirai Y, Takemoto R, Suzuki T, Hashiguchi T, Yanagi Y.   +6 more
europepmc   +2 more sources

Outbreak of neuropathogenic equid herpesvirus 1 causing abortions in Yili horses of Zhaosu, North Xinjiang, China

BMC Veterinary Research, 2022
Background EHV-1 is one of the most serious viral pathogens that frequently cause abortion in horses around the world. However, so far, relatively little information is available on EHV-1 infections as they occur in China.
Panpan Tong, Ruli Duan, Nuerlan Palidan, Haifeng Deng, Liya Duan, Meiling Ren, Xiaozhen Song, Chenyang Jia, Shuyao Tian, Enhui Yang, Ling Kuang, Jinxin Xie   +11 more
doaj   +1 more source

Neuropathogenic and non-neuropathogenic EHV-1 strains induce the accumulation of hyperphosphorylated Tau in primary murine neurons

Acta virologica, 2020
Equid herpesvirus 1 (EHV-1) causes respiratory disease, abortion and neurological disorders in horses. Similarly, to other alphaherpesviruses, EHV-1 is neurotropic and establishes latency in the neurons of its natural host. Despite the fact that many studies have been devoted to the pathogenesis of various clinical forms of EHV-1 infection, mechanisms ...
Joanna Cymerys-Bulenda, Anna Słońska-Zielonka, Marcin Chodkowski, Anna Golke, Małgorzata Krzyżowska, Marcin Bańbura   +5 more
openaire   +3 more sources

Human Foamy Virus: An Underestimated Neuropathogen?

Brain Pathology, 1991
Human foamy virus (HFV) is a recently characterized retrovirus which was originally isolated from patients with various neoplastic and degenerative diseases. However, until today it has not been possible to identify HFV as the causative agent of any disease and little is known about its prevalence in human populations.
A, Aguzzi, K, Bothe, E F, Wagner, A, Rethwilm, I, Horak   +4 more
openaire   +2 more sources