A novel PCR protocol for detection and differentiation of neuropathogenic and non-neuropathogenic equid alphaherpesvirus 1 [PDF]
Journal of Veterinary Diagnostic Investigation, 2019 Equid alphaherpesvirus 1 (EHV-1) infections can have a major impact on the horse industry and equine welfare by causing abortion or respiratory or neurologic disease. A single nucleotide polymorphism (A 2254 →G 2254 ) in open reading frame (ORF) 30 ...
Lechmann, Julia +5 more
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Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity [PDF]
, 2020 Viruses naturally engage innate immunity, induce antigen presentation, and mediate CD8 T cell priming against foreign antigens. Polioviruses can provide a context optimal for generating antigen-specific CD8 T cells, as they have natural tropism for ...
Dobrikova, Elena Y +9 more
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Paired immunoglobulin-like receptor B is an entry receptor for mammalian orthoreovirus
Nature Communications, 2023 Mammalian orthoreovirus (reovirus) infects most mammals and is associated with celiac disease in humans. In mice, reovirus infects the intestine and disseminates systemically to cause serotype-specific patterns of disease in the brain.
Pengcheng Shang +14 more
doaj +1 more source
Molecular Biological and Pathological Studies on Neuropathogenic Avian Leukosis Viruses and the Molecular Clones [PDF]
, 2023 岩手大学博士（獣医学）原著論文 Nishiura, H., Kubota, I., Kondo, Y., Kachi, M., Hatai, H., Sasaki, J., Goryo, M. and Ochiai, K. Neuropathogenicity of newly isolated avian leukosis viruses from chickens with osteopetrosis and mesenchymal neoplasms Avian Pathology 49(5 ...
西浦, 颯, NISHIURA, Hayate
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The ORF37 (UL24) is a neuropathogenicity determinant of equine herpesvirus 1 (EHV-1) in the mouse encephalitis model [PDF]
, 2010 Equine herpesvirus 1 (EHV-1) bacterial artificial chromosome clone (Ab4p BAC) was established based on neuropathogenic strain Ab4p. ORF37 encoding UL24 was replaced with a selection cassette, rpsL-neo gene, to produce an ORF37 deletion mutant, Ab4p∆ORF37.
Yamaguchi, Tsuyoshi +9 more
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T cell deficiency precipitates antibody evasion and emergence of neurovirulent polyomavirus
eLife, 2022 JC polyomavirus (JCPyV) causes progressive multifocal leukoencephalopathy (PML), a life-threatening brain disease in immunocompromised patients. Inherited and acquired T cell deficiencies are associated with PML.
Matthew D Lauver +6 more
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Measles Fusion Machinery Is Dysregulated in Neuropathogenic Variants [PDF]
mBio, 2015 ABSTRACT Paramyxoviruses, including the human pathogen measles virus (MV), enter host cells by fusing their viral envelope with the target cell membrane. This fusion process is driven by the concerted actions of the two viral envelope glycoproteins, the receptor binding protein (hemagglutinin [H]) and the fusion (F) protein.
Jurgens, Eric M +6 more
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Subacute sclerosing panencephalitis(SSPE): Viral mutation and neuropathogenicity.
Uirusu, 2003 Ayata, Minoru, Ogura, Hisashi
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Type I IFN response to Papiine herpesvirus 2 (Herpesvirus papio 2; HVP2) determines neuropathogenicity in mice [PDF]
, 2009 Isolates of baboon α-herpesvirus Papiine herpesvirus 2 (HVP2) exhibit one of two distinct phenotypes in mice: extremely neurovirulent or apathogenic. Previous studies implicated the type I interferon (IFN) response as being a major factor in controlling ...
Deatheridge, M. +7 more
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Neuropathogenicity and Sensitivity to Antibody Neutralization of Lactate Dehydrogenase-Elevating Virus Are Determined by Polylactosaminoglycan Chains on the Primary Envelope Glycoprotein [PDF]
, 2000 Common strains of lactate dehydrogenase-elevating virus (LDV, an arterivirus), such as LDV-P and LDV-vx, are highly resistant to antibody neutralization and invariably establish a viremic, persistent, yet asymptomatic, infection in mice.
Plagemann, Peter G.W. +2 more
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